SOLODERM OINT 15G

SOLODERM OINT 15G

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  • Manufacturer ALI GOHAR PHARMACEUTICALS (PVT.) LTD.
  • Generic Name Ofloxacin, Clobetasol, ornidazole, Terbinafine HCL

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Description

    The combination medication containing Ofloxacin, Clobetasol, Ornidazole, and Terbinafine HCl works synergistically through multiple mechanisms of action. Ofloxacin, a fluoroquinolone antibiotic, inhibits DNA gyrase and topoisomerase IV, disrupting bacterial DNA replication and repair. Clobetasol, a potent synthetic corticosteroid, exerts its anti-inflammatory effects by binding to corticosteroid receptors and modulating gene expression, leading to reduced inflammation and immune response. Ornidazole, a nitroimidazole antibiotic, interferes with DNA synthesis in susceptible anaerobic bacteria and protozoa, resulting in their death. Terbinafine HCl, an antifungal agent, inhibits squalene epoxidase, an enzyme crucial for ergosterol biosynthesis in fungal cell membranes, disrupting fungal cell growth and proliferation. Together, these components provide broad-spectrum antimicrobial activity and anti-inflammatory effects.

  • Ingredients

    Ofloxacin, Clobetasol, ornidazole, Terbinafine HCL
  • Drug Class

    Topical antibiotic and antifungal with anti-inflammatory properties.

  • Dosage Form

    Ointment

  • Uses

    The following are the uses of Ofloxacin, Clobetasol, ornidazole, Terbinafine HCL Ointment:

    • Used for treating bacterial skin infections
    • Used to relieve inflammation and itching in various skin conditions
    • Used for its antibacterial and antiparasitic properties, targeting a range of microorganisms
    • Used to combat fungal infections on the skin, particularly those caused by dermatophytes
    • Used for managing skin conditions where a combination of antibacterial, anti-inflammatory, and antifungal action is required
    • Used to prevent the spread of infection and promote healing in skin wounds
    • Used to alleviate symptoms associated with bacterial and fungal skin infections, such as redness, swelling, and discomfort
    • Used as a topical treatment for skin infections, providing a localized and direct approach to managing these conditions
  • In case of Overdose

    In the case of an overdose of Ofloxacin, Clobetasol, Ornidazole, and Terbinafine HCL Ointment, there is a potential for adverse effects. Ocular exposure to Ofloxacin can cause eye irritation and possible corneal damage. Clobetasol, when ingested, may lead to systemic corticosteroid effects, while oral Ornidazole overdose can result in nausea, vomiting, and central nervous system effects. Topical application of large quantities of Terbinafine could potentially lead to local skin reactions.

  • Missed Dose

    In the case of a missed dose of Ofloxacin, it is recommended to take it as soon as you remember, but if it is almost time for the next dose, skip the missed dose and continue with your regular schedule. For Clobetasol, apply the missed dose as soon as possible, but skip it if it's almost time for the next application. If you miss a dose of oral ornidazole, take it as soon as you remember, unless it's close to the next dose. For Terbinafine HCL Ointment, apply the missed dose immediately, or wait until the next scheduled application if it's almost time.

  • How To Use

    To apply Ofloxacin, Clobetasol, Ornidazole, and Terbinafine HCL Ointment, clean and dry the affected area, then gently apply a thin layer of the ointment using a sterile applicator or your fingers, ensuring you cover the entire affected skin area as directed by your healthcare provider or according to the instructions provided with the medication.

  • When Not to Use

    Here are the situations when Ofloxacin, Clobetasol, Ornidazole, and Terbinafine HCL Ointment should not be used:

    • Avoid using this combination ointment if you have a known allergy or sensitivity to any of the active ingredients Ofloxacin, Clobetasol, Ornidazole, or Terbinafine HCL.
    • Do not apply this ointment near the eyes, mouth, or other mucous membranes.
    • Contraindicated in patients with a history of allergic reactions to similar antibiotics (e.g., Ciprofloxacin, Levofloxacin).
    • Should not be used in individuals with a history of tendon disorders or tendon rupture.
    • Not recommended for children, pregnant or breastfeeding women, and the elderly.
    • Avoid using this ointment on extensive areas of the body or for prolonged periods without medical supervision.
    • Do not use if you have a skin condition called eczema (a type of skin inflammation).
    • Contraindicated in individuals with a history of photosensitivity reactions.
    • Do not use if you have an allergic skin reaction or severe irritation after applying the ointment.
    • Should not be used on open wounds or broken skin.
  • Side Effects

    The possible side effects of Ofloxacin, Clobetasol, Ornidazole, and Terbinafine HCL Ointment may include:

    • Skin irritation or redness at the application site
    • Burning or stinging sensation
    • Dry skin or peeling
    • Itching or rash
    • Increased skin sensitivity to sunlight
    • Headache
    • Nausea and vomiting
    • Ornidazole may cause a metallic taste in the mouth.
    • In rare cases, it may lead to dizziness, sleepiness, or diarrhea.
  • Precautions & Warnings

    Following are the precautions and warnings for Ofloxacin, Clobetasol, Ornidazole, and Terbinafine HCL Ointment:

    • Avoid contact with eyes, nose, and mouth as it is strictly for external use only.
    • Do not use this ointment if you are allergic to any of its ingredients.
    • It should be used with caution in children and the elderly, as they may be more sensitive to its effects.
    • Do not cover the treated area with airtight dressings or bandages as it may increase the risk of side effects.
    • Avoid prolonged use without consulting a doctor, especially on large areas of the body or open wounds.
    • If you are pregnant, breastfeeding, or planning to become pregnant, consult your doctor before using this medication.
    • Keep this medication out of reach of children and pets.
  • Drug Interactions

    Following are the drug interactions for Ofloxacin, Clobetasol, Ornidazole, and Terbinafine HCL Ointment:

    • Concomitant use with other topical corticosteroids may increase the risk of skin thinning, delayed wound healing, and local irritation.
    • CYP2D6 inhibitors, such as fluoxetine or paroxetine, may increase terbinafine levels, leading to a higher risk of systemic side effects.
    • Warfarin may have an increased anticoagulant effect when combined with ornidazole, requiring close monitoring of INR levels.
    • Drugs that prolong the QT interval, such as amiodarone or fluoroquinolones, may increase the risk of QT prolongation when combined with ofloxacin.
    • Alcohol should be avoided with ornidazole as it may cause disulfiram-like reactions, including nausea, vomiting, and flushing.
    • CYP450 enzyme inducers, such as rifampin or phenytoin, may decrease terbinafine's effectiveness by increasing its metabolism.
    • Immunosuppressants, such as cyclosporine, may have altered blood levels when combined with terbinafine, requiring dose adjustments.
  • Food Interactions

    Following are the food interactions for Ofloxacin, Clobetasol, Ornidazole, and Terbinafine HCL Ointment:

    • Grapefruit and grapefruit juice should be avoided as they may interfere with the metabolism of the drugs, leading to increased drug levels and potential side effects.
    • Alcohol should be consumed with caution, especially with Ofloxacin and Ornidazole, as it can enhance the risk of side effects such as nausea, dizziness, and stomach discomfort.
    • Avoid high-fat meals with Ofloxacin as it may affect its absorption.
    • Clobetasol may cause increased thirst and sodium intake, so ensure adequate fluid and electrolyte balance.
    • Avoid caffeine-rich foods and beverages as they can interact with Ornidazole, potentially increasing its side effects.
    • Terbinafine HCL may cause changes in taste; consider adjusting your diet accordingly to maintain nutritional balance.
    • Follow a healthy diet to support overall skin health when using Clobetasol.
    • No specific food restrictions are mentioned for Terbinafine HCL Ointment, but maintaining a balanced diet is advisable.
  • Storage/Disposal

    Ofloxacin, Clobetasol, Ornidazole, and Terbinafine HCL Ointment should be stored in a cool, dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. Keep the ointment in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. Avoid exposure to extreme temperatures by not storing it in the bathroom or near heat sources. Always check the expiration date, and dispose of any expired or unused ointment responsibly. Do not dispose of it in sinks, toilets, or drains; instead, follow local guidelines or consult healthcare professionals for appropriate disposal methods. Keep the medication out of children's reach to prevent accidental contact or ingestion.

  • Quick Tips, if any

    Following are the quick tips for Ofloxacin, Clobetasol, Ornidazole, and Terbinafine HCL Ointment:

    • Apply a thin layer to the affected area as directed by your doctor.
    • Wash your hands before and after application to maintain hygiene.
    • Use the ointment as prescribed, ensuring not to miss any doses for effective treatment.
    • Avoid applying to broken or irritated skin, and discontinue use if irritation persists.
    • Do not cover the treated area with bandages or tight clothing to allow the skin to breathe.
    • Store the ointment at room temperature, away from heat and direct sunlight.
    • Consult your pharmacist or healthcare provider if you have any concerns or experience unusual symptoms.

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