Sopral Plus (5/6.25mg) 14 Tablets

Sopral Plus (5/6.25mg) 14 Tablets

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  • Manufacturer Bryon Pharmaceuticals (Pvt.) Ltd
  • Generic Name

    Bisoprolol 5mg, Hydrochlorothiazide

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Description

    Bisoprolol/Hydrochlorothiazide is a combination medication that works by two distinct mechanisms of action. Bisoprolol, a beta-blocker, acts by blocking beta-1 adrenergic receptors in the heart, which reduces heart rate and decreases cardiac output, resulting in lower blood pressure. This mechanism helps to reduce the workload on the heart and improve cardiovascular function. Hydrochlorothiazide, on the other hand, is a diuretic that inhibits the reabsorption of sodium and chloride ions in the distal tubule of the kidneys, leading to increased excretion of water and electrolytes, thereby reducing blood volume and subsequently lowering blood pressure. Together, these two components work synergistically to provide effective blood pressure control by reducing cardiac output and lowering peripheral vascular resistance.

  • Ingredients

    Bisoprolol 5mg, Hydrochlorothiazide

  • Drug Class

    Beta-blocker and diuretic.

  • Dosage Form

    Tablet

  • Uses

    The following are the uses of Bisoprolol 5mg, Hydrochlorothiazide Tablet:

    • Used for treating high blood pressure (hypertension)
    • Used to lower the risk of heart-related issues in patients with stable heart disease
    • Used to manage and control heart rate in conditions like tachycardia
    • Used to reduce chest pain (angina) and improve heart function
    • Used to manage mild to moderate heart failure
    • Used to relieve symptoms like shortness of breath and fatigue in heart-related conditions
    • Used to prevent potential heart issues in patients with a history of heart attack
  • In case of Overdose

    In the case of an overdose of Bisoprolol 5mg and Hydrochlorothiazide tablets, individuals may experience symptoms such as dizziness, severe fatigue, slow heart rate, and a significant drop in blood pressure. It is crucial to recognize the signs of an overdose, which can include extreme lightheadedness, fainting, and difficulty breathing. Promptly seeking medical assistance is essential if an overdose is suspected, as healthcare professionals can provide the necessary treatment and support to manage any adverse effects effectively.

  • Missed Dose

    In the case of a missed dose of Bisoprolol 5mg, it is generally recommended to take the missed dose as soon as you remember, but if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. For Hydrochlorothiazide, if you miss a dose, take it as soon as you remember, however, if it is near the time of your next dose, skip the missed dose and continue with your regular dosing regimen. It is important to maintain a consistent medication routine, but if you frequently miss doses, consult your healthcare provider for advice on how to manage your medication schedule effectively.

  • How To Use

    To take Bisoprolol 5mg and Hydrochlorothiazide Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, as directed by your healthcare provider, and follow the prescribed dosage instructions provided.

  • When Not to Use

    Here are the conditions or situations when Bisoprolol 5mg, Hydrochlorothiazide Tablet should not be taken:

    • Should not be used in patients with a known allergy to Bisoprolol, Hydrochlorothiazide, or any of its components.
    • Contraindicated in patients with severe bradycardia (very slow heart rate).
    • Not suitable for individuals with cardiogenic shock.
    • Should not be used in patients with severe hepatic impairment or active liver disease.
    • Contraindicated during severe renal impairment or patients with anuria (absence of urine production).
    • Not recommended for patients with severe respiratory failure or acute bronchospasm.
    • Avoid in patients with metabolic acidosis.
    • Should not be used during pregnancy or breastfeeding.
    • Not suitable for individuals with uncontrolled asthma or chronic obstructive pulmonary disease (COPD).
    • Should be avoided in patients with severe peripheral vascular disease.
  • Side Effects

    The side effects of Bisoprolol 5mg, Hydrochlorothiazide Tablet may include:

    • Fatigue and weakness
    • Dizziness or lightheadedness
    • Headache
    • Gastrointestinal issues like nausea, diarrhea, or constipation
    • Cold extremities (hands and feet)
    • Slow heart rate (bradycardia)
    • Sleep disturbances
    • Respiratory issues, such as shortness of breath or wheezing
  • Precautions & Warnings

    Following are the precautions and warnings:

    • Bisoprolol and Hydrochlorothiazide combination is not suitable for individuals with a known allergy to either Bisoprolol or Hydrochlorothiazide, or any other sulfonamide-derived drugs.
    • This medication should be used with caution in patients with kidney or liver disease, as it may require dosage adjustments.
    • Patients with a history of respiratory diseases like asthma or chronic obstructive pulmonary disease (COPD) should exercise caution, as Bisoprolol may exacerbate these conditions.
    • Hydrochlorothiazide can cause imbalances in blood electrolytes, particularly potassium and sodium. Regular monitoring is necessary to prevent complications.
    • It may cause dizziness or lightheadedness, especially when standing up from a sitting or lying position. Patients should rise slowly to prevent falls.
    • Diabetic patients should be aware that Hydrochlorothiazide may increase blood sugar levels, and Bisoprolol may mask the early warning symptoms of low blood sugar.
    • Patients should inform their healthcare provider if they have a history of heart problems, glaucoma, or systemic lupus erythematosus before taking this medication.
    • Pregnant or breastfeeding women should consult their doctor, as this medication may not be suitable during these periods.
  • Drug Interactions

    Following are the drug interactions for Bisoprolol 5mg and Hydrochlorothiazide Tablet:

    • Bisoprolol may enhance the effects of other drugs that lower blood pressure, such as ACE inhibitors, leading to excessive hypotension.
    • Hydrochlorothiazide can decrease the elimination of lithium, increasing lithium levels and the risk of lithium toxicity.
    • Nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the antihypertensive effect of Bisoprolol and Hydrochlorothiazide, and increase the risk of renal impairment.
    • Bisoprolol may increase the concentration of digoxin, requiring careful monitoring of digoxin levels.
    • The hypokalemic effect of Hydrochlorothiazide can be enhanced by corticosteroids or ACTH, potentially causing severe hypokalemia.
    • Antidiabetic medication effects may be altered, as Hydrochlorothiazide can decrease glucose tolerance.
    • Caution is advised with anesthetics, as Bisoprolol may enhance the cardiovascular depressive effects of anesthetic agents.
    • The use of other diuretics or potassium-depleting agents may increase the risk of hypokalemia.
  • Food Interactions

    Following are the food interactions to be aware of when taking Bisoprolol 5mg and Hydrochlorothiazide Tablet:

    • Grapefruit and grapefruit juice should be avoided as they can decrease the breakdown of Bisoprolol, leading to increased levels of the medication in the body and potentially causing more side effects.
    • Alcohol may increase the risk of dizziness and drowsiness with Bisoprolol, so it's best to limit or avoid alcohol consumption.
    • Maintain a consistent potassium-rich diet, as Hydrochlorothiazide can cause potassium loss. Include foods like bananas, oranges, and spinach.
    • Salt substitutes containing potassium should be used with caution, as Hydrochlorothiazide may affect potassium levels.
    • Limit caffeine intake, as it may increase blood pressure and interact with Bisoprolol's blood pressure-lowering effect.
    • Stay well-hydrated, especially when starting Hydrochlorothiazide, to prevent dehydration and maintain proper electrolyte balance.
    • Avoid excessive dieting or rapid weight loss, as it can affect blood pressure and the effectiveness of these medications.
    • Consult your doctor or pharmacist about any specific dietary restrictions or recommendations tailored to your health condition.
  • Storage/Disposal

    Bisoprolol 5mg and Hydrochlorothiazide Tablets should be stored in a secure and dry location, away from direct sunlight and moisture. Keep the tablets in their original packaging, ensuring the container is tightly sealed to maintain their integrity. Avoid exposing the medication to high temperatures or storing it in the bathroom, as heat and humidity can degrade its quality. Pay attention to the expiration date on the package, and never use the tablets beyond this date. When disposing of unused or expired tablets, do not flush them or throw them into the trash. Instead, follow local guidelines for medication disposal or consult a pharmacist for safe disposal methods. It is crucial to keep these tablets out of children's reach to prevent accidental consumption.

  • Quick Tips, if any

    Following are the quick tips for Bisoprolol 5mg and Hydrochlorothiazide Tablet:

    • Take the medication as directed by your doctor, usually once daily at the same time each day.
    • Swallow the tablet whole with a glass of water, preferably in the morning.
    • Do not crush, chew, or break the tablet.
    • Avoid taking antacids or indigestion remedies within 2 hours of taking this medicine.
    • Inform your doctor if you have any kidney or liver problems before starting the medication.
    • Do not stop taking the medicine without consulting your doctor, even if you feel well.
    • Store the tablets in a cool, dry place, away from direct sunlight.
    • Keep all medications out of sight and reach of children.

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