Soprazon (15mg) 10 Capsules

Itraconazole, a medication available in a 15mg capsule formulation, exhibits its antifungal activity through multiple mechanisms of action. Primarily, it interferes with the synthesis of ergosterol, a crucial component of fungal cell membranes. By inhibiting the enzyme lanosterol 14-alpha-demethylase, which is essential for converting lanosterol to ergosterol, itraconazole disrupts the integrity and function of fungal cell membranes. This disruption leads to impaired membrane fluidity, altered membrane permeability, and ultimately, the inhibition of fungal growth and proliferation. Additionally, itraconazole may affect other cellular processes in fungi, such as inhibiting the production of other sterols and interfering with fungal metabolism, further contributing to its antifungal efficacy.

Itraconazole 15mg

Antifungal (Azole derivative)

Capsule

The following are the uses of Itraconazole 15mg Capsule:

• Used for treating fungal infections, especially in the lungs, mouth, throat, and fingernails.
• Used to manage fungal conditions like aspergillosis and histoplasmosis.
• Effective against infections caused by yeast and certain types of fungus.
• Helps treat fungal infections in the brain, heart, and other internal organs.
• Can be used to prevent fungal infections in individuals with weak immune systems.
• Provides relief from symptoms associated with fungal infections.
• Used in combination with other medications for comprehensive fungal treatment.

In the case of an overdose of Itraconazole 15mg capsules, immediate medical attention is necessary. The severity of symptoms can vary depending on the amount ingested. Common signs may include nausea, vomiting, dizziness, and in more serious cases, liver or kidney damage. Prompt treatment can help mitigate these effects, so it is crucial to seek medical assistance promptly if an overdose is suspected. Healthcare professionals should be informed about the quantity consumed to ensure appropriate management.

In the case of a missed dose of Itraconazole 15mg Capsule, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication and maintain its effectiveness.

To take Itraconazole 15mg Capsule, swallow the capsule whole with a full glass of water, preferably with a meal or as directed by your healthcare professional, and follow the prescribed dosage instructions provided by your doctor for the duration of the treatment.

Following are the conditions/situations when Itraconazole 15mg Capsule should not be used:

• Must not be used in individuals with a known allergy or hypersensitivity to Itraconazole or other similar medications.
• Not suitable for patients with a history of liver disease or impaired liver function.
• Contraindicated in patients with severe heart failure or a history of heart disease.
• Should not be used in patients with a history of arrhythmias (irregular heart rhythms).
• Not recommended for individuals with a rare inherited condition called porphyria.
• Avoid in patients with a history of Long QT syndrome or other heart rhythm disorders.
• Do not use if you have a history of kidney disease or are on dialysis.
• Contraindicated in patients with low potassium or magnesium levels in the blood.

The side effects of Itraconazole 15mg Capsule may include:

• Nausea and vomiting
• Diarrhea
• Abdominal pain
• Headache
• Dizziness
• Skin rash or itching
• Fatigue and weakness
• Elevated liver enzymes

Following are the precautions and warnings for Itraconazole 15mg Capsule:

• This medication is not recommended for individuals with a known hypersensitivity or allergy to Itraconazole or other related azole antifungal drugs.
• Itraconazole can cause liver problems, so regular monitoring of liver function is necessary. Discontinue use if any signs of liver damage occur.
• Patients with a history of heart disease should use this medication with caution, as it may affect heart rhythm.
• It may cause visual disturbances; patients experiencing such symptoms should exercise caution when driving or operating machinery.
• Elderly patients may be more susceptible to side effects; dosage adjustments might be required.
• This medication may interact with other drugs, including certain antacids, rifampicin, and some HIV medications. Inform your doctor of all medications you are taking.
• Itraconazole capsules should be swallowed whole and not crushed or chewed, as this can affect their effectiveness.

Following are the drug interactions for Itraconazole 15mg Capsule:

• Co-administration with drugs that prolong QT interval (e.g., pimozide, quinidine, dofetilide) can increase the risk of cardiac arrhythmias.
• Itraconazole can significantly increase blood levels of HMG-CoA reductase inhibitors (statins), such as simvastatin and atorvastatin, leading to an increased risk of rhabdomyolysis.
• Avoid combining with erythromycin, as it can increase the risk of cardiac toxicity and QT prolongation.
• The effect of warfarin and other oral anticoagulants may be enhanced, requiring close monitoring of coagulation parameters.
• Itraconazole may increase plasma concentrations of certain benzodiazepines, leading to enhanced sedation and respiratory depression.
• Drugs that induce CYP3A4 enzymes (e.g., rifampin, carbamazepine) can reduce the effectiveness of Itraconazole.
• Concomitant use with ciclosporin or tacrolimus may lead to elevated blood levels of these immunosuppressants, increasing the risk of toxicity.

Following are the food interactions for Itraconazole 15mg Capsule:

• Grapefruit and grapefruit juice consumption should be avoided as they can significantly increase the levels of Itraconazole in the blood, leading to potential toxicity.
• Avoid high-fat meals as they can decrease the absorption of Itraconazole, reducing its effectiveness.
• Limit caffeine intake as Itraconazole can increase caffeine levels in the body, causing nervousness and rapid heartbeat.
• Alcohol should be avoided or limited as it can increase the risk of liver-related side effects and may also reduce the effectiveness of Itraconazole.
• Avoid consuming food rich in pectin, like apples and oranges, as pectin can bind to Itraconazole and reduce its absorption.
• Do not consume charcoal-broiled meat as it can decrease the effectiveness of Itraconazole.
• Always take Itraconazole on an empty stomach, at least 1 hour before or 2 hours after a meal, for optimal absorption.
• Consult your healthcare provider for specific dietary recommendations during Itraconazole treatment.

Itraconazole 15mg capsules should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. Keep the capsules in their original container, tightly sealed, to maintain their integrity and prevent contamination. It is crucial not to expose the medication to excessive heat or cold, so avoid storing it near heat sources or in the bathroom. Proper disposal of any unused or expired capsules is essential; do not flush them or pour them down the drain. Consult your pharmacist for safe disposal options, and always keep medications away from children to prevent accidental consumption. Regularly check the expiration date, and remember to replace the medication if it has expired.

Following are the quick tips for Itraconazole 15mg Capsule:

• Consult your doctor for the correct dosage and duration based on your medical condition.
• Swallow the capsule whole with water; do not crush or chew.
• Take it consistently at the same time each day to maintain stable blood levels.
• Ensure you complete the full course of medication as prescribed.
• Inform your doctor about all the medications you are taking to avoid potential drug interactions.
• Store the capsules in a cool, dry place, away from direct sunlight and moisture.
• If you experience any severe side effects or persistent symptoms, seek medical attention immediately.
• Do not share this medication with others, even if their symptoms appear similar.