SPADIX INJ

Phloroglucinol and trimethylphloroglucinol work together through a multi-step mechanism of action. Phloroglucinol is an antispasmodic agent functions by inhibiting smooth muscle contractions in the gastrointestinal tract. It works by blocking calcium channels, which reduces intracellular calcium levels and leads to muscle relaxation. This action alleviates spasms and cramping, providing relief from abdominal pain. Trimethylphloroglucinol is a derivative also exhibits antispasmodic properties by acting on smooth muscle tissue. It modulates the action of neurotransmitters, further reducing muscle contractions and promoting relaxation in the gastrointestinal tract. The combination is particularly effective for treating functional gastrointestinal disorders, such as irritable bowel syndrome (IBS), by relieving abdominal pain and discomfort associated with spasms.

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Spasmolytic agent

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Injection

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Phloroglucinol and its methylated derivative are antispasmodic agents acting on smooth muscle. Aim To evaluate the efficacy of phloroglucinol/trimethylphloroglucinol on pain intensity during an acute exacerbation of pain of irritable bowel syndrome over a 1-week period treatment.

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SPADIX dosage for the indication of smooth muscle spasms, duration as advised:

• Adults - 1-2 vials injected as directed by a physician.
• Children - Not recommended.

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Overdose is rare but may cause gastrointestinal issues. Seek medical help if symptoms persist.

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If you miss a dose, consume as soon as you remember. If it is close to the next feeding, skip the missed dose. Do not double up on doses.

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Usually taken orally with food. Follow the prescribed dosage and frequency.

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Phloroglucinol, trimethylphloroglucinol should not be used if:

• Hypersensitivity
• Severe renal impairment

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Dizziness, drowsiness, weakness, blurred vision, dry eyes, dry mouth, nausea, constipation, and abdominal bloating may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

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This product may contain inactive ingredients (such as preservatives like benzalkonium chloride), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

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The drug interactions with phloroglucinol and trimethylphloroglucinol include:

• Other Antispasmodics – May enhance effects, increasing the risk of side effects.

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Phloroglucinol and trimethylphloroglucinol have no documented food interactions that affect their efficacy or safety. There are no specific dietary restrictions or food-related effects on their absorption. It is important to use phloroglucinol and trimethylphloroglucinol according to your healthcare provider's instructions to ensure optimal results.

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Store Phloroglucinol and Trimethylphloroglucinol according to the manufacturer’s instructions, typically in a cool, dry place, away from light and moisture. Ensure they are kept in their original containers and out of reach of children. Dispose of any expired or unused medications local disposal guidelines or through a drug take-back program.

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