SPEDRA TAB

Avanafil's primary mechanism of action is the selective inhibition of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). PDE5 is an enzyme found in various tissues, including the corpus cavernosum of the penis. When sexually stimulated, Avanafil blocks the degradation of cGMP by inhibiting PDE5. This inhibition leads to increased levels of cGMP, which promotes smooth muscle relaxation in the blood vessels supplying the penis. As a result, blood flow to the penis is enhanced, facilitating the achievement and maintenance of an erection. By selectively targeting PDE5, Avanafil helps improve erectile function without affecting other phosphodiesterase enzymes involved in different physiological processes.

PDE5 inhibitor.

Tablet

The following are the uses of Avanafil Tablet:

• Used for treating erectile dysfunction, helping men achieve and maintain an erection.
• Used to improve sexual performance and satisfaction.
• Used to enhance blood flow to the penis, ensuring better erections.
• Used to address sexual health issues related to physical and psychological factors.
• Used to manage underlying conditions affecting sexual function.
• Used to restore sexual confidence and intimacy in relationships.
• Used as a short-term treatment option for ED, providing effective results.

In the case of an overdose of Avanafil Tablets, it is important to recognize the potential severity of the situation. Initial symptoms may include prolonged and painful erections, which could indicate a serious adverse reaction. Prompt medical intervention is necessary to manage these symptoms and prevent further complications. Seek emergency care and provide healthcare professionals with information regarding the dosage and timing of the overdose to ensure appropriate treatment.

In the case of a missed dose of Avanafil Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or alarms to help you stay on track with your medication routine. Consult your healthcare provider if you have any concerns or questions regarding missed doses.

To take Avanafil tablets, swallow one tablet whole with water, preferably on an empty stomach, approximately 30 minutes before sexual activity, following the dosage instructions provided by your healthcare professional.

Following are the conditions/situations when Avanafil Tablet should not be used:

• Must not be taken by individuals who are allergic to Avanafil or similar medications, or have a history of severe allergic reactions.
• Contraindicated in patients with a history of heart attack, stroke, or life-threatening irregular heart rhythm within the past 6 months.
• Should not be used in individuals with low blood pressure or uncontrolled high blood pressure.
• Not recommended for individuals with severe liver impairment.
• Avoid using this medication if you have a history of retinitis pigmentosa (an eye disease).
• Do not take Avanafil if you are currently using nitrates or nitric oxide donors.
• Contraindicated in patients who have lost their vision due to a condition called non-arteritic anterior ischaemic optic neuropathy (NAION).
• Should not be used in individuals with severe kidney disease requiring dialysis.

The side effects of Avanafil Tablet may include:

• Headache
• Dizziness
• Flushing (feeling of warmth or redness in the face)
• Nasal congestion or runny nose
• Back pain
• Sore throat
• Nausea
• Blurred vision

Following are the precautions and warnings:

• Avanafil should not be used by individuals who are allergic to any of its components, and any known allergies to medications should be disclosed to the healthcare provider.
• Patients with cardiovascular diseases, including heart problems, irregular heartbeats, or a history of heart attacks, should use Avanafil with caution, as it may affect blood pressure.
• This medication is not recommended for individuals with severe liver or kidney disease, as it is primarily metabolized in the liver and excreted by the kidneys.
• Avanafil can cause a drop in blood pressure, so patients should be cautious if they have low blood pressure or are taking medications to lower blood pressure.
• Patients taking nitrates or nitric oxide donors should not use Avanafil, as it can lead to a dangerous drop in blood pressure.
• It is important to avoid excessive alcohol consumption while taking Avanafil, as it may increase the risk of side effects, especially dizziness and fainting.
• Patients should seek immediate medical attention if an erection lasts for more than 4 hours or is painful, as this may cause permanent damage to the penis.
• Avanafil should not be used in combination with other erectile dysfunction medications, as it may increase the risk of side effects and adverse reactions.

Following are the potential interactions for Avanafil Tablet:

• Avanafil should not be used with nitrates or nitric oxide donors (e.g., nitroglycerin) as this can cause a significant drop in blood pressure, leading to serious cardiovascular events.
• Concurrent use with alpha-blockers (e.g., tamsulosin) can enhance the blood pressure-lowering effects, leading to an increased risk of hypotension, dizziness, or fainting.
• Avanafil may interact with CYP3A4 inhibitors (e.g., ketoconazole, ritonavir), leading to an increased concentration of Avanafil in the blood, which could increase the risk of side effects.
• It may interact with certain antihypertensive medications, enhancing their blood pressure-lowering effects, so blood pressure should be monitored during treatment.
• Avanafil should be used cautiously with drugs that may prolong the QT interval (e.g., certain antiarrhythmics), as it may increase the risk of serious heart arrhythmias.
• Using Avanafil alongside other PDE5 inhibitors (e.g., sildenafil, tadalafil) is not recommended as it may increase the risk of side effects such as headaches, dizziness, or priapism.
• Alcohol consumption with Avanafil may increase the risk of side effects such as dizziness, headache, and hypotension.
• Antacids or H2 antagonists (e.g., ranitidine) may reduce the absorption of Avanafil, potentially decreasing its effectiveness.
• If taking other medications for erectile dysfunction or pulmonary hypertension, caution is advised to avoid potential drug interactions and excessive effects.

Following are the food interactions:

• Avanafil should not be taken with high-fat meals, as they can delay its absorption and reduce its effectiveness.
• Avoid consuming alcohol in large amounts while taking Avanafil, as it may increase the risk of side effects like dizziness, headaches, or low blood pressure.
• Grapefruit and grapefruit juice should be avoided, as they can increase the concentration of Avanafil in the blood, raising the risk of side effects.
• Avoid consuming large amounts of caffeine while on Avanafil, as it may cause increased heart rate or exacerbate side effects like jitteriness.
• High-sodium foods should be limited, as they may affect blood pressure regulation while on Avanafil.

Avanafil tablets should be stored in a cool, dry place at room temperature, ideally between 68°F and 77°F (20°C and 25°C). It is crucial to keep the medication in its original container, tightly sealed, to maintain its integrity and prevent exposure to moisture or humidity. Avoid storing the tablets in the bathroom or kitchen cabinets, as these areas may have temperature fluctuations and increased humidity. Always check the expiration date before using the medication, and discard any expired or unused tablets properly. When disposing of Avanafil tablets, do not flush them down the toilet or pour them into a drain. Instead, follow local guidelines or consult a pharmacist for safe disposal methods to protect the environment. Keep the medication out of children's reach to prevent accidental ingestion.

Following are the quick tips for Avanafil Tablet:

• Consult your doctor before taking this medication, especially if you have any heart-related issues.
• Take the tablet as directed by your doctor, usually 15-30 minutes before sexual activity.
• Do not take more than one tablet in a 24-hour period.
• Avoid heavy meals and excessive alcohol as they may reduce the effectiveness of the medication.
• Store the tablets at room temperature, away from moisture and heat.
• Inform your doctor about all the medications you are taking to prevent potential drug interactions.
• Seek immediate medical attention if you experience a prolonged erection (priapism) or any allergic reactions.