Sporanox (100mg) 4 Capsules

Itraconazole 100mg capsules exert their antifungal activity primarily through the inhibition of ergosterol synthesis. Ergosterol is a crucial component of fungal cell membranes. The drug binds to the cytochrome P450 enzyme lanosterol 14α-demethylase, which is responsible for converting lanosterol to ergosterol. By inhibiting this enzyme, itraconazole disrupts the fungal cell membrane structure and function, leading to impaired membrane integrity and ultimately, fungal cell death. This selective inhibition of fungal sterol synthesis is the key mechanism through which itraconazole exhibits its potent antifungal effects, without significantly affecting mammalian cells that do not produce ergosterol.

Itraconazole 100mg

Antifungal, Azole Derivative.

Capsule

The following are the uses of Itraconazole 100mg Capsule:

• Used for treating fungal infections, especially those caused by Aspergillus and Candida species.
• Used for controlling and preventing fungal infections in immunocompromised patients.
• Used for treating dermatophytosis, a fungal infection of the skin, hair, or nails.
• Used for managing chronic pulmonary aspergillosis, a long-term lung infection.
• Used for treating blastomycosis, a fungal infection affecting the lungs and potentially spreading to other organs.
• Used for suppressing fungal infections in patients with AIDS to improve their overall health.
• Used for managing histoplasmosis, a fungal infection that can affect the lungs and other organs.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Treatment of Aspergillus infection - 100-200 mg daily (divided bid to qid) for 2-4 weeks
• Treatment of yeast infections - 200 mg daily for 6 weeks
• Pulse treatment of fungal infections - 800 mg daily for 1 day, followed by 400 mg once daily for 4 days in combination with amphotericin B
• Prophylaxis of invasive aspergillus - 200-400 mg daily (po or iv)
• Safe and effective dose for prophylaxis of P. Aeruginosa pneumonia - 400 mg once daily

In the case of an overdose of Itraconazole 100mg Capsules, individuals may experience symptoms such as nausea, vomiting, diarrhea, and dizziness. Severe cases could lead to more serious effects like liver damage or cardiovascular issues. Prompt medical intervention is necessary to manage these symptoms and prevent potential long-term complications. Treatment may involve gastric lavage, supportive care, and monitoring of vital signs and organ function until the patient stabilizes.

In the case of a missed dose of Itraconazole 100mg Capsule, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for advice on how to safely resume your medication regimen and ensure the best treatment outcome.

To take Itraconazole 100mg Capsule, swallow the capsule whole with a full glass of water, preferably with a meal or as directed by your healthcare professional, ensuring you complete the full course of medication as prescribed.

Following are the conditions/situations when Itraconazole 100mg Capsule should not be used:

• Should not be taken by individuals who have a known allergy or hypersensitivity to Itraconazole or other similar medications.
• Contraindicated in patients with a history of heart failure or existing heart problems.
• Not suitable for individuals with liver disease or impaired liver function.
• Should not be used if you have a history of a certain type of irregular heartbeat (QT prolongation).
• Avoid using this medication if you have a blood disorder called porphyria.
• Contraindicated in patients with a history of kidney problems or those undergoing dialysis.
• Should not be taken during pregnancy or while breastfeeding.
• Not recommended for individuals with a rare genetic problem of galactose intolerance, severe lactase deficiency, or glucose-galactose malabsorption.

The side effects of Itraconazole 100mg Capsule may include:

• Nausea and vomiting
• Diarrhea or constipation
• Abdominal pain
• Headache
• Dizziness or vertigo
• Skin rashes or itching
• Fatigue and weakness
• Elevated liver enzymes

Following are the precautions and warnings for Itraconazole 100mg Capsule:

• Itraconazole should be used with caution in patients with liver disease, as it can affect liver function. Regular monitoring of liver enzymes is recommended during treatment.
• Patients with a history of heart problems, such as congestive heart failure or arrhythmias, should be closely monitored while taking this medication.
• This medication may cause visual disturbances and dizziness. Patients should avoid driving or operating heavy machinery until they know how this medication affects them.
• Itraconazole can interact with other medications, including certain anti-depressants, anti-seizure drugs, and statins. Inform your doctor about all medications you are taking.
• Elderly patients may be more susceptible to side effects, particularly related to the heart and liver. Close monitoring is advised in this population.
• Avoid consuming grapefruit or grapefruit juice while taking Itraconazole, as it can increase the concentration of the drug in the body.
• Pregnant and breastfeeding women should consult their doctor before using this medication, as it may cause harm to the fetus or infant.
• Discontinuing the medication abruptly may lead to a return of the fungal infection. Follow your doctor's instructions for stopping the treatment.

Following are the drug interactions for Itraconazole 100mg Capsule:

• Avoid combining with other medications that prolong the QT interval, such as certain antiarrhythmics or antipsychotics, due to increased risk of cardiac arrhythmias.
• Itraconazole can significantly increase blood levels of statins, calcium channel blockers, and certain antiarrhythmics, leading to increased risk of adverse effects.
• Concomitant use with H2-receptor antagonists or proton pump inhibitors may reduce the absorption of Itraconazole, decreasing its effectiveness.
• Rifampicin and certain antiepileptic drugs can induce the metabolism of Itraconazole, reducing its efficacy.
• Erythromycin and other CYP3A4 inhibitors can increase Itraconazole levels, potentially leading to adverse events.
• The effectiveness of oral contraceptives may be reduced when taken with Itraconazole.
• Grapefruit juice should be avoided as it can increase Itraconazole concentrations, leading to potential toxicity.

Following are the food interactions for Itraconazole 100mg Capsule:

• Grapefruit and grapefruit juice should be avoided as they can increase the levels of Itraconazole in the blood, leading to potential toxicity.
• High-fat meals can enhance the absorption of Itraconazole, so it is recommended to take the medication with a meal or a fatty snack to improve its effectiveness.
• Avoid excessive consumption of licorice as it may interfere with Itraconazole's metabolism and potentially reduce its effectiveness.
• Limit caffeine intake as Itraconazole can increase its effects, leading to symptoms like nervousness, restlessness, and rapid heartbeat.
• Alcohol may cause liver damage and should be avoided or consumed in moderation while taking Itraconazole, as it can increase the risk of liver-related side effects.
• Avoid consuming large amounts of cranberry juice as it may decrease Itraconazole's effectiveness by altering its absorption.
• Be cautious with high-salt foods as Itraconazole can increase the risk of edema, and a high-salt diet may exacerbate this side effect.
• Always consult your healthcare provider for specific dietary recommendations and to ensure safe and effective use of Itraconazole.

Itraconazole 100mg capsules should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. The original container should be tightly sealed to maintain its integrity and prevent contamination. Avoid exposing the capsules to extreme temperatures by keeping them away from heat sources and direct sunlight. Proper disposal of unused or expired medication is crucial; do not flush or pour them down the drain. Consult your pharmacist or healthcare professional for guidance on safe disposal methods. Keep the medication securely stored away from children to prevent accidental consumption. Always prioritize the safety and effectiveness of the medication by adhering to these storage and disposal guidelines.

Following are the quick tips for Itraconazole 100mg Capsule:

• Take the capsule as directed by your doctor, typically once or twice daily.
• Swallow the capsule whole with a full glass of water; do not crush or chew.
• Itraconazole can be taken with or without food, but taking it with a meal may reduce stomach upset.
• Maintain a consistent routine by taking your doses at the same time each day.
• Avoid grapefruit juice and its products while on this medication to prevent interactions.
• Store the capsules at room temperature, away from moisture and sunlight.
• Regularly monitor your health and report any unusual symptoms to your doctor.

Itraconazole is an antifungal medication that works wonders for treating fungal infections, but it requires a few lab tests to ensure your safety and positive reaction to the drug. These tests are usually done before and during your treatment with Itraconazole 100mg. Your doctor will likely order a blood test to check your overall health and monitor any changes that may occur during treatment. They'll check your blood count, liver and kidney function, and cholesterol levels, so you'll know right away if anything is out of whack. Itraconazole can harm your liver, so regular liver function tests are necessary to monitor any signs of toxicity. You'll be keeping an eye on levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin, and albumin to make sure everything is in balance. Kidney function will also be monitored, especially for those with existing kidney problems or the elderly, to detect any changes early. eGFR and BUN will be checked regularly, so you can be aware of any effects on your kidneys. Since Itraconazole can cause eye abnormalities, it's important to have an eye examination before starting the medication and throughout your treatment. Those with pre-existing heart conditions or a history of prolonged QT interval may require electrocardiogram (ECG) monitoring to check for any heart-related side effects. Lastly, Itraconazole can interact with other medications, so be sure to inform your doctor about all the medications you are currently taking. They may adjust the dosage or prescribe something else if needed. These tests are important to ensure that Itraconazole is safe and effective for you and to monitor for any potential risks or side effects. Let me know if you have any other questions!