STABLON TAB

Tianeptine's mechanism of action primarily involves its interaction with the brain's neurotransmitter systems, particularly the serotonin and glutamate pathways. It acts as a selective serotonin reuptake enhancer (SSRE), meaning it increases the reuptake of serotonin in certain brain regions, leading to increased serotonin availability in the synaptic cleft. This modulation of serotonin transmission is believed to contribute to tianeptine's antidepressant effects. Additionally, tianeptine interacts with glutamate receptors, particularly the NMDA (N-methyl-D-aspartate) receptors, by indirectly reducing glutamate release. This regulation of glutamate activity may play a role in its neuroprotective and anxiolytic properties. Tianeptine's unique mechanism of action, combining serotonin modulation and glutamate regulation, is thought to contribute to its efficacy in treating depressive disorders and related symptoms.

Tricyclic antidepressant.

Tablet

The following are the uses of tianeptine Tablet:

• Used for treating major depressive episodes in adults.
• Used to manage symptoms of depression, including persistent feelings of sadness, hopelessness, and loss of interest in activities.
• Used to improve mood and emotional well-being by regulating brain chemicals like serotonin.
• Used to help patients regain energy, improve sleep patterns, and increase overall daily functioning.
• Used to alleviate anxiety and physical symptoms associated with depression.
• Used as part of a comprehensive treatment plan, often combined with therapy for optimal results.
• Used to prevent depressive symptoms from worsening and to maintain long-term mental health stability.

In the case of an overdose of Tianeptine tablets, immediate symptoms may include severe drowsiness, dizziness, and nausea. Excessive doses can lead to a rapid heartbeat, difficulty breathing, and even loss of consciousness. Prompt medical intervention is required, as an overdose may result in serious health complications, particularly if combined with other substances. It is crucial to seek emergency medical care if an overdose is suspected, as timely treatment can prevent potential long-term effects and ensure a better outcome.

In the case of a missed dose of tianeptine tablets, it is generally recommended to take the missed dose as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. It is important to maintain a consistent medication routine, but if you frequently miss doses, consult your healthcare provider for advice on how to improve adherence and ensure the effectiveness of the treatment.

To take Tianeptine tablets, place the tablet under your tongue and allow it to dissolve completely, preferably in the morning or as directed by your healthcare professional, without chewing or swallowing it.

Following are the conditions/situations when Tianeptine Tablet should not be used:

• Must not be used in individuals with a known allergy or hypersensitivity to Tianeptine or any of the tablet's components.
• Not suitable for patients with a history of severe liver or kidney disease.
• Contraindicated in individuals with a history of seizures or epilepsy, as it may lower the seizure threshold.
• Should not be used in patients with a history of gastrointestinal obstruction or conditions causing slow digestion.
• Not recommended for individuals with suicidal thoughts or those who have recently attempted suicide.
• Avoid using Tianeptine in patients with a history of drug abuse or addiction, as it may have the potential for dependence.
• Contraindicated during breastfeeding, as it may pass into breast milk and harm the nursing infant.

The side effects of tianeptine Tablet may include:

• Dry mouth
• Dizziness
• Blurred vision
• Constipation
• Nausea and vomiting
• Stomach pain
• Skin rash or itching
• Increased heart rate

Following are the precautions and warnings for Tianeptine Tablet:

• Do not exceed the recommended dosage, as it may lead to serious adverse effects and potential addiction.
• Tianeptine should be used with caution in patients with a history of substance abuse or addiction, as it has the potential for dependence and withdrawal symptoms.
• It may cause drowsiness and impair cognitive function, so patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Elderly patients may be more sensitive to the effects of tianeptine, so dosage adjustments might be necessary.
• Patients with liver or kidney impairment should be monitored closely, as tianeptine is primarily metabolized in the liver and excreted by the kidneys.
• Do not abruptly discontinue the medication; gradually reduce the dosage to minimize withdrawal symptoms.
• Tianeptine should be used during pregnancy and breastfeeding only if the potential benefits outweigh the risks, and under the supervision of a healthcare professional.
• Keep this medication out of the reach of children and pets, and store it in a secure location to prevent accidental ingestion.

Following are the drug interactions for Tianeptine Tablet:

• Alcohol and benzodiazepines can cause increased sedation and drowsiness when taken with tianeptine.
• Tianeptine may reduce the effectiveness of anticoagulants like warfarin, potentially leading to blood clotting issues.
• It can interact with antidepressants such as selective serotonin reuptake inhibitors (SSRIs) and monoamine oxidase inhibitors (MAOIs), increasing the risk of serotonin syndrome.
• Tianeptine might affect the metabolism of certain drugs processed by the liver, such as carbamazepine and phenytoin.
• Opioid medications, when combined with tianeptine, can lead to enhanced respiratory depression.
• The effectiveness of anti-anxiety medications, such as buspirone, may be reduced by tianeptine.
• Some antipsychotic drugs may have their effects potentiated when used alongside tianeptine.

Following are the food interactions for Tianeptine Tablet:

• Tianeptine may cause increased drowsiness, avoid alcohol as it can enhance this effect.
• Grapefruit and grapefruit juice should be consumed with caution as they can alter the drug's metabolism, leading to increased side effects.
• High-fat meals can slightly delay the absorption of tianeptine, but this is generally not clinically significant.
• Caffeine-containing beverages should be limited as tianeptine may increase their effects, leading to potential nervousness and insomnia.
• Avoid aged cheeses and cured meats as they may contain tyramine, which can interact with tianeptine and raise blood pressure.
• Be cautious with spicy foods as they might influence the gastrointestinal system, potentially affecting the drug's absorption.
• Keep a balanced diet, ensuring adequate hydration, as tianeptine may cause dry mouth and mild constipation.
• Always consult your healthcare provider about specific dietary adjustments when taking this medication.

Tianeptine Tablets should be stored in a secure and dry location, preferably at room temperature, ensuring protection from light and moisture. Maintain the tablets in their original packaging, tightly sealed, to preserve their integrity and prevent contamination. It is crucial not to expose the medication to extreme temperatures or humidity, so avoid storing it in bathrooms or near heat sources. Regularly check the expiration date, and if the medication is no longer needed or has expired, do not flush or pour it down the drain. Contact your pharmacist or healthcare provider for guidance on safe disposal methods to protect the environment and prevent misuse. Keep the tablets out of children's reach to ensure their safety.

Following are the quick tips for Tianeptine Tablet:

• Take the tablet as directed by your doctor, typically once or twice a day.
• Swallow the tablet whole with a full glass of water.
• You can take it with or without food, but be consistent with your choice.
• Maintain a regular schedule to ensure steady levels of the medication in your body.
• Do not crush or chew the tablet to avoid altering its effectiveness.
• Avoid alcohol consumption while taking tianeptine as it may enhance side effects.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.