STELABID TAB

Isopropamide and Trifluoperazine, both present in the tablet, have distinct mechanisms of action. Isopropamide primarily acts as an anticholinergic agent, blocking the action of acetylcholine at muscarinic receptors in the central and peripheral nervous systems. This inhibition reduces gastric acid secretion, decreases gastrointestinal motility, and relaxes gastrointestinal smooth muscles, which collectively contribute to its therapeutic effects in gastrointestinal disorders. Trifluoperazine, on the other hand, is a phenothiazine derivative with antipsychotic properties. It primarily acts as a dopamine antagonist, blocking dopamine receptors in the brain, particularly D2 receptors. This action helps to reduce psychotic symptoms and is responsible for the antipsychotic effects of Trifluoperazine. The combined use of these two drugs may be employed to manage conditions where both gastrointestinal symptoms and psychotic manifestations are present, providing a synergistic approach to treatment.

Isopropamide, Trifluoperazine

Antipsychotic and Anticholinergic

Tablet

The following are the uses of Isopropamide, Trifluoperazine Tablet:

• Used for treating psychotic disorders, such as schizophrenia and severe anxiety.
• Used for controlling symptoms like hallucinations, delusions, and agitated behavior.
• Used for managing severe nausea and vomiting, especially in postoperative settings.
• Used for reducing abnormal movements and muscle stiffness.
• Used for alleviating severe itching and hives caused by various conditions.
• Used for managing symptoms of Parkinson's disease and drug-induced Parkinsonism.
• Used for treating severe motion sickness and vertigo.
• Used for short-term management of severe anxiety disorders.

In the case of an overdose of Isopropamide and Trifluoperazine tablets, individuals may experience severe side effects. Symptoms can include drowsiness, confusion, and an irregular heartbeat. It is crucial to seek medical assistance promptly, as overdose can lead to life-threatening complications, particularly for those with pre-existing heart conditions. Timely intervention is vital to ensure the best possible outcome.

In the case of a missed dose of Isopropamide and Trifluoperazine Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. It is generally advised not to double the dose to make up for a missed one. Consult your healthcare professional if you have any concerns or if you frequently miss doses. They can provide guidance tailored to your specific situation.

To take the Isopropamide, Trifluoperazine Tablet, swallow the tablet whole with a full glass of water, preferably in the morning or as directed by your healthcare professional, and follow the prescribed dosage and treatment duration as instructed by your doctor.

Following are the conditions/situations when Isopropamide, Trifluoperazine Tablet should not be used:

• Should not be taken by individuals with a known allergy to Isopropamide, Trifluoperazine, or any other phenothiazine medications.
• Contraindicated in patients with a history of blood disorders such as low white blood cell count or bone marrow depression.
• Not suitable for patients with severe liver or kidney disease.
• Should be avoided in individuals with a history of seizures or epilepsy.
• Must not be used in patients with a suspected or confirmed blood dyscrasia (blood disorder).
• Contraindicated in patients who have been diagnosed with narrow-angle glaucoma.
• Should not be given to patients who are in a coma or are unconscious.
• Not recommended for individuals with severe cardiovascular disease or conditions like myocarditis.
• Should be used with caution and avoided if possible in elderly patients with dementia, as it may increase the risk of death.
• Avoid using this medication in patients who are taking other medications that may interact, especially central nervous system depressants.

The side effects of Isopropamide, Trifluoperazine Tablet may include:

• Dry mouth
• Blurred vision
• Constipation
• Dizziness
• Sedation or drowsiness
• Skin rashes
• Muscle stiffness
• Difficulty urinating

Following are the precautions and warnings for Isopropamide, Trifluoperazine Tablet:

• This medication should be used with caution in patients with a history of liver or kidney disease, as it may require dosage adjustments or close monitoring.
• Patients with a known hypersensitivity or allergy to isopropamide, trifluoperazine, or any of the tablet's components should not take this medication.
• Elderly patients may be more sensitive to the side effects, particularly the potential for confusion, dizziness, and orthostatic hypotension.
• Trifluoperazine may cause drowsiness and impaired judgment; patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• The use of alcohol should be avoided as it can increase the risk of certain side effects and may also enhance the sedative effects of trifluoperazine.
• Isopropamide may cause dry mouth, so patients are advised to practice good oral hygiene to reduce the risk of dental problems.
• This medication may cause orthostatic hypotension (a sudden drop in blood pressure upon standing), so caution should be exercised to avoid falls or accidents.
• Patients with a history of seizures or epilepsy should use this medication with caution, as it may lower the seizure threshold.

Following are the drug interactions for Isopropamide, Trifluoperazine Tablet:

• Alcohol and other CNS depressants may enhance the sedative effects of Trifluoperazine, leading to increased drowsiness and impaired motor skills.
• Isopropamide can interact with anticholinergic drugs, causing increased anticholinergic side effects such as dry mouth, blurred vision, and constipation.
• Drugs metabolized by CYP450 enzymes, especially CYP2D6, may have altered metabolism when used with Trifluoperazine, potentially affecting their effectiveness.
• The effectiveness of Isopropamide may be reduced by medications that increase gastrointestinal motility, such as metoclopramide.
• Antipsychotics and other medications that lower the seizure threshold may increase the risk of seizures when used with Trifluoperazine.
• Trifluoperazine may enhance the effects of other antihypertensive medications, leading to excessive blood pressure drop.
• Drugs that prolong the QT interval, such as certain antiarrhythmic medications, should be used cautiously with Trifluoperazine due to the potential for cardiac arrhythmias.

Following are the food interactions for Isopropamide, Trifluoperazine Tablet:

• Grapefruit and grapefruit juice should be avoided as they can interfere with the metabolism of Trifluoperazine, leading to increased levels of the drug in the body and potentially causing more side effects.
• Alcohol should be consumed with caution as it may enhance the sedative effects of Trifluoperazine, causing increased drowsiness and dizziness.
• Foods high in fat can slow down the absorption of Isopropamide, possibly reducing its effectiveness.
• Avoid caffeine-rich foods and beverages as they can increase the side effects of Trifluoperazine, including nervousness and insomnia.
• Salt intake should be monitored as Trifluoperazine can cause sodium retention, which may be a concern for those on a low-sodium diet.
• Antacids containing aluminum or magnesium may decrease the absorption of Isopropamide if taken together. Separate the doses by at least 2 hours.
• Foods and beverages with high tyramine content, such as aged cheeses, cured meats, and fermented foods, should be avoided as they can interact with Trifluoperazine, leading to a potentially dangerous increase in blood pressure.
• Always ensure you are well-hydrated when taking this medication, as dehydration can increase the risk of side effects.

Isopropamide and Trifluoperazine tablets should be stored in a secure, dry location at room temperature, away from light and moisture. The original container should be tightly sealed to maintain its integrity and prevent contamination. It's crucial to avoid storing the tablets in bathrooms or near heat sources like ovens or heaters, as temperature fluctuations can impact their effectiveness. Always check the expiration date before using any medication, and dispose of unused or expired tablets responsibly. Do not flush them or pour them down the drain; consult a pharmacist or healthcare professional for appropriate disposal methods. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Isopropamide, Trifluoperazine Tablet:

• Consult your doctor before starting this medication for personalized advice.
• Swallow the tablet whole without crushing or chewing for proper absorption.
• Take the tablet with a full glass of water to aid swallowing.
• Adhere to the prescribed dosage and duration for best results.
• Avoid alcohol as it may intensify side effects.
• Inform your doctor about all medications you are taking to prevent interactions.
• Store the tablets at room temperature, away from moisture and sunlight.