STIEMYCIN DS 60ML

Erythromycin, the active ingredient in Erythromycin Syrup/Suspension, primarily exhibits its antibacterial activity by binding to the 50S subunit of the bacterial ribosome, thereby inhibiting protein synthesis. This binding interferes with the translocation step in protein synthesis, preventing the proper alignment of the ribosome and leading to the disruption of bacterial protein production. Erythromycin is particularly effective against gram-positive bacteria and some gram-negative bacteria, as it can penetrate their cell walls and reach the ribosomes in the cytoplasm. The mechanism of action selectively targets bacterial ribosomes, making it effective in treating various infections caused by susceptible microorganisms.

Erythromycin

Macrolide antibiotic

Suspension

The following are the uses of Erythromycin Syrup/Suspension:

• Used for treating respiratory tract infections such as pneumonia and bronchitis.
• Used for managing skin infections like impetigo and cellulitis.
• Used for controlling whooping cough (Pertussis).
• Used for treating ear infections, especially in children.
• Used for gastrointestinal infections, including those caused by Helicobacter pylori.
• Used for preventing and treating bacterial endocarditis.
• Used for managing Legionnaires' disease.
• Used for providing an alternative treatment option for patients allergic to penicillin.

In the case of an overdose of Erythromycin Syrup/Suspension, individuals may experience gastrointestinal symptoms such as nausea, vomiting, and diarrhea. It can also lead to more severe effects like hearing loss, dizziness, and liver problems. Prompt medical intervention is necessary, and healthcare professionals should be informed about the amount ingested to ensure appropriate treatment. The patient's vital signs and liver function should be closely monitored, and supportive care provided as needed.

In the case of a missed dose of Erythromycin Syrup/Suspension, it is important to administer the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. However, if you miss multiple doses or an entire day's worth of medication, contact your healthcare provider for guidance on how to proceed, as they may advise you to restart the medication or provide alternative instructions.

To take Erythromycin Syrup/Suspension, shake the bottle well, then use a measuring device like a dosing spoon or syringe to measure the prescribed amount, and take it orally, following the dosage instructions provided by your healthcare professional, typically 2 to 4 times a day, either with or without food, as directed.

Here are the conditions or situations when Erythromycin Syrup/Suspension should not be used:

• Do not use if the patient has a known allergy to erythromycin or other macrolide antibiotics.
• Avoid in patients with a history of liver problems or jaundice caused by previous erythromycin use.
• Not suitable for patients with severe kidney disease or impairment.
• Should not be used in patients with a history of Long QT syndrome or irregular heart rhythms.
• Contraindicated in individuals with a known or suspected sensitivity to benzoyl peroxide (if the suspension contains this ingredient).
• Do not use in patients with a history of pyloric stenosis.
• Avoid using in newborns with intestinal problems or preterm infants.
• Erythromycin should not be used in patients with a history of hearing loss or tinnitus.

The side effects of Erythromycin Syrup/Suspension may include:

• Nausea and vomiting
• Diarrhea
• Abdominal pain
• Loss of appetite
• Skin rashes and itching
• Hearing loss or ringing in the ears (tinnitus)
• Fatigue and weakness
• Jaundice (yellowing of the skin or eyes)

Following are the precautions and warnings for Erythromycin Syrup/Suspension:

• Do not use if you are allergic to Erythromycin or similar antibiotics, as it may trigger a severe allergic reaction.
• This medication should be used with caution in patients with liver or kidney disease, as it is primarily metabolized in the liver and excreted by the kidneys.
• Erythromycin can interact with other drugs, including anticoagulants, statins, and certain asthma medications, so inform your doctor about all medications you are taking.
• Prolonged use may result in bacterial or fungal overgrowth, or the development of antibiotic-resistant bacteria.
• Do not take this medication if you have a history of liver problems or jaundice caused by previous erythromycin use.
• Avoid using Erythromycin if you have a history of cardiac issues, as it may cause irregular heart rhythms.
• This medication may cause Clostridium difficile-associated diarrhea, a serious condition that can lead to severe colon damage if not treated promptly.

Following are the drug interactions for Erythromycin Syrup/Suspension:

• Erythromycin can inhibit the metabolism of drugs metabolized by CYP3A4 enzyme, e.g., simvastatin, leading to increased drug levels and potential toxicity.
• Concomitant use with ergotamine or dihydroergotamine may increase the risk of ergot toxicity, causing ergotism.
• Theophylline levels may increase when used with Erythromycin, potentially leading to theophylline toxicity.
• It can interact with statins like atorvastatin, increasing the risk of muscle damage (rhabdomyolysis).
• When combined with drugs like digoxin, Erythromycin may increase digoxin levels, requiring careful monitoring.
• Warfarin and other anticoagulants may have enhanced effects, increasing the risk of bleeding.
• The effectiveness of oral contraceptives may be reduced, potentially leading to unintended pregnancy.

Following are the food interactions for Erythromycin Syrup/Suspension:

• Avoid consuming grapefruit and grapefruit juice as they can alter the drug's metabolism, leading to increased levels of Erythromycin in the body.
• Alcohol consumption should be limited or avoided as it may increase the risk of side effects, particularly liver-related issues.
• Dairy products like milk and cheese may decrease the absorption of Erythromycin, so it's best to take the medication 2 hours before or after consuming these foods.
• High-fat meals can delay the absorption of Erythromycin, so it is advisable to take the medication on an empty stomach.
• Avoid consuming large amounts of caffeine as it may enhance the drug's effects and increase the risk of side effects.
• Erythromycin may decrease the effectiveness of live bacterial probiotics, so consider spacing out the medication and probiotic supplements.
• Certain foods like leafy greens, fortified cereals, and some legumes contain vitamin K, which can interact with Erythromycin, affecting blood clotting.
• Always consult your healthcare provider for specific dietary recommendations while taking this medication.

Erythromycin Syrup/Suspension should be stored with caution, preferably in a cool and dry place away from direct sunlight, heat, and moisture. Keep the medication in its original container, tightly sealed, to maintain its integrity and prevent contamination. It is crucial to adhere to the recommended storage conditions to ensure the effectiveness and safety of the medication. Always check the expiration date, and if the syrup is expired or no longer needed, do not dispose of it by flushing or pouring it down the drain. Contact your pharmacist or healthcare provider for guidance on appropriate disposal methods to minimize environmental impact. Additionally, exercise vigilance by keeping the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Erythromycin Syrup/Suspension:

• Administer the prescribed dosage as directed by your healthcare professional for effective treatment.
• Ensure thorough shaking of the bottle prior to each use for a well-mixed medication.
• Consume the syrup with a glass of water, avoiding tea, coffee, or dairy for better absorption.
• Maintain a consistent dosing schedule by taking the medication at the same time daily.
• If stomach irritation occurs, consider taking the syrup with food or post-meal for relief.
• Store the medication safely, keeping it out of children's reach to prevent accidental ingestion.
• Consult your doctor if symptoms persist or worsen during the course of treatment.
• Inform your healthcare provider about any other medications you are taking to avoid potential interactions.