Stilnox CR (12.5mg) 28 Tablets

Zolpidem tartrate 12.5mg tablets primarily act as a selective agonist of the gamma-aminobutyric acid (GABA) receptor subtype A, specifically the alpha-1 subunit. This mechanism of action enhances the inhibitory effects of GABA in the central nervous system, leading to sedative, hypnotic, and anxiolytic effects. By selectively binding to these receptors, zolpidem promotes sleep initiation and helps maintain sleep by modulating the sleep-wake cycle. It reduces the time it takes to fall asleep and increases the duration of sleep, while also improving sleep quality. The selective action of zolpidem on specific GABA receptors helps to minimize side effects and reduce the potential for dependence compared to some other sleep medications.

Zolpidem Tartrate:

Tablet

The following are the uses of Zolpidem Tartrate 12.5mg Tablet:

• Used for treating insomnia and difficulty falling asleep.
• Used to improve sleep quality and increase total sleep time.
• Used for resetting the sleep-wake cycle in individuals with disturbed sleep patterns.
• Used for managing sleep issues in shift workers or those with jet lag.
• Used to enhance sleep continuity and reduce night-time awakenings.
• Used for short-term treatment of insomnia, typically for 7-10 days.

In the case of an overdose of Zolpidem Tartrate 12.5mg Tablets, it is important to recognize the potential severity of the situation. Symptoms may include extreme drowsiness, confusion, difficulty breathing, and even loss of consciousness. Prompt medical intervention is necessary, as healthcare professionals can provide the appropriate treatment to manage the overdose and prevent potential complications. Timely action can significantly impact the outcome and ensure the individual's safety.

In the case of a missed dose of Zolpidem Tartrate 12.5mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take extra medicine to make up for the missed dose, as this may increase the risk of side effects. If you miss several doses, consult your healthcare professional for advice on how to safely resume your medication. It is generally best to take the missed dose as soon as possible to maintain the effectiveness of the treatment.

To take Zolpidem Tartrate 12.5mg Tablets, swallow the tablet whole with a glass of water, preferably on an empty stomach, just before bedtime, following the dosage instructions provided by your healthcare professional.

Following are the conditions/situations when Zolpidem Tartrate 12.5mg Tablet should not be taken:

• Do not take if you have a known allergy to Zolpidem or any other ingredients in the tablet.
• Avoid if you have a history of sleep apnea or other breathing disorders.
• Not suitable for individuals with severe liver impairment.
• Should not be used if you have a recent history of depression or psychiatric disorders.
• Contraindicated in patients with myasthenia gravis.
• Do not take this medication if you have a history of complex sleep behaviors, such as sleepwalking or sleep-eating.
• Not recommended for individuals with a history of substance abuse or addiction.
• Avoid if you have respiratory depression or severe lung disease.
• Should not be used if you are unable to get a full night's sleep (7-8 hours) before being active again.

The side effects of Zolpidem Tartrate 12.5mg Tablet may include:

• Dizziness
• Headache
• Daytime drowsiness
• Confusion or memory problems
• Uncontrollable shaking of a part of the body (tremors)
• Nausea and vomiting
• Dry mouth
• Diarrhea

Following are the precautions and warnings for Zolpidem Tartrate 12.5mg Tablet:

• This medication is for short-term use only, typically 7-10 days. Prolonged use can lead to dependence and withdrawal symptoms.
• Zolpidem should be used with caution in elderly patients as they may be more sensitive to its effects and are at higher risk of experiencing side effects.
• Patients with a history of depression, mental illness, or suicidal thoughts should be closely monitored while taking this medication.
• Avoid alcohol consumption while using Zolpidem, as it can intensify the medication's sedative effects and increase the risk of accidents.
• Zolpidem may impair your thinking and reactions, so refrain from driving or operating machinery until you know how this medication affects you.
• Inform your doctor if you have a history of lung or breathing problems, as Zolpidem can worsen these conditions.
• Do not increase the dosage without medical advice, as it may lead to severe side effects and overdose.
• Zolpidem may cause allergic reactions; seek immediate medical help if you experience difficulty breathing, hives, or swelling.

Following are the drug interactions for Zolpidem Tartrate 12.5mg Tablet:

• Alcohol and other central nervous system (CNS) depressants (e.g., benzodiazepines, opioids) can increase the sedative effects of Zolpidem, leading to severe drowsiness and impaired breathing.
• Rifampin, a strong CYP3A4 inducer, may decrease the effectiveness of Zolpidem by increasing its metabolism.
• Ketoconazole, a potent CYP3A4 inhibitor, can increase Zolpidem blood levels, potentially leading to prolonged sedation and impaired psychomotor function.
• The effectiveness of Zolpidem may be reduced when taken with St. John's Wort, as it induces CYP3A4 enzyme activity.
• Antidepressants like Fluoxetine and Paroxetine can inhibit the metabolism of Zolpidem, leading to increased drug levels and potential side effects.
• Anticonvulsants such as Phenytoin and Carbamazepine may decrease Zolpidem levels by inducing its metabolism.
• Caution is advised with medications that affect gastric pH, as increased stomach acidity can enhance Zolpidem absorption, potentially increasing its sedative effects.

Following are the food interactions for Zolpidem Tartrate 12.5mg Tablet:

• Avoid alcohol as it can increase the sedative effects and impair your ability to perform tasks requiring alertness.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of Zolpidem, potentially leading to increased drug levels in the body.
• Fatty foods may delay the absorption of Zolpidem, but they do not significantly impact its effectiveness.
• Avoid high-fat meals before bedtime as they can disrupt sleep patterns and potentially interact with the medication's effects.
• Caffeine intake should be minimized, especially close to bedtime, as it can interfere with sleep and counteract the sedative effects of Zolpidem.
• Avoid heavy or spicy meals late in the evening as they may cause discomfort and affect sleep quality.
• Some herbal supplements like St. John's Wort may interact with Zolpidem, so consult a healthcare professional before combining them.
• Always take Zolpidem on an empty stomach as directed by your doctor to ensure optimal absorption and effectiveness.

Zolpidem Tartrate 12.5mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area, away from direct sunlight, moisture, and extreme temperatures. It is crucial to keep the tablets in their original packaging or container, ensuring the lid is tightly sealed to maintain their integrity. When disposing of unused or expired tablets, it is important to follow proper procedures. Do not discard them in household trash or flush them down the toilet. Instead, contact your local pharmacy or healthcare facility to inquire about medication take-back programs or disposal guidelines specific to your region. This ensures the safe and environmentally responsible handling of Zolpidem Tartrate tablets, preventing any potential harm to others or the environment.

Following are the quick tips for Zolpidem Tartrate 12.5mg Tablet:

• Take the tablet just before bedtime as directed by your doctor.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• Zolpidem is a short-term sleep aid, do not use it for extended periods without consulting your doctor.
• Avoid alcohol and other sedatives while taking this medication.
• Do not drive or operate machinery until you know how this medicine affects you.
• Inform your doctor about all medications you are currently taking to avoid potential interactions.
• Store the tablets at room temperature, away from light and moisture.