Sulzone (1g) 1 Injection

Ceftriaxone 500mg and Sulbactam 500mg in combination work synergistically to provide broad-spectrum antibacterial activity. Ceftriaxone, a third-generation cephalosporin, primarily acts by binding to and inhibiting the penicillin-binding proteins (PBPs) involved in bacterial cell wall synthesis, leading to cell lysis. This inhibition disrupts the cross-linking of peptidoglycan chains, weakening the cell wall and resulting in bacterial death. Sulbactam, a beta-lactamase inhibitor, protects ceftriaxone from degradation by inhibiting beta-lactamase enzymes produced by certain bacteria, thus enhancing ceftriaxone's effectiveness against beta-lactamase-producing organisms. This combination ensures that ceftriaxone can exert its bactericidal effect by inhibiting cell wall synthesis in a wider range of bacteria, including those that produce beta-lactamases.

Ceftriaxone 500mg, Sulbactam 500mg

Cephalosporin/Penicillin combination

Injection

The following are the uses of Ceftriaxone 500mg, Sulbactam 500mg injection:

• Used for treating severe bacterial infections such as pneumonia, meningitis, and skin and soft tissue infections.
• Used for combating infections caused by bacteria resistant to other antibiotics.
• Used for surgical prophylaxis to prevent infections during high-risk surgeries.
• Used for managing intra-abdominal infections, particularly those associated with the gastrointestinal tract.
• Used for treating bone and joint infections, ensuring effective penetration to these sites.
• Used for controlling infections in immunocompromised patients, providing a broad spectrum of coverage.
• Used for treating hospital-acquired infections, especially in intensive care settings.
• Used for managing skin structure infections, including those with underlying conditions.

In the case of an overdose of Ceftriaxone 500mg and Sulbactam 500mg injection, the patient may experience an increased risk of adverse effects. Symptoms of overdose can include severe nausea, vomiting, diarrhea, and potential kidney damage. Prompt medical intervention is necessary, as healthcare professionals may need to provide supportive care and monitor vital functions to ensure the patient's well-being and manage any potential complications effectively.

In the case of a missed dose of Ceftriaxone 500mg, Sulbactam 500mg injection, it is important to administer the medication as soon as possible. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for the missed one. If you have missed multiple doses, contact your healthcare professional for advice on how to get back on track with your treatment plan. It is crucial to maintain a consistent medication routine for optimal effectiveness.

To administer Ceftriaxone 500mg and Sulbactam 500mg injection, ensure the vial is at room temperature, clean the injection site with an alcohol swab, and carefully inject the entire contents of the vial intramuscularly or intravenously as directed by your healthcare provider, following the prescribed dosage and administration instructions provided.

Following are the conditions or situations when Ceftriaxone 500mg and Sulbactam 500mg injection should not be used:

• Allergy Should not be administered to individuals with a known allergy to Ceftriaxone, Sulbactam, or any other beta-lactam antibiotics.
• Premature infants Not recommended for use in premature newborns, especially those with jaundice or hyperbilirubinemia.
• Bile duct disorders Contraindicated in patients with biliary tract obstruction or other conditions affecting bile flow.
• Hypersensitivity Should not be used in patients with a history of severe hypersensitivity reactions to antibiotics.
• Vitamin K deficiency Not suitable for individuals with known vitamin K deficiency or those at risk of bleeding disorders.
• Neonatal hyperbilirubinemia Should be avoided in newborns with a risk of hyperbilirubinemia or those with a family history of jaundice.
• Calcium-containing solutions Must not be mixed or administered with calcium-containing solutions or products due to the risk of precipitation.

The side effects of Ceftriaxone 500mg, Sulbactam 500mg injection may include:

• Diarrhea
• Nausea and vomiting
• Skin rashes or itching
• Headache
• Dizziness
• Injection site reactions (pain, swelling, or redness)
• Allergic reactions (hives, difficulty breathing, swelling of the face/lips/tongue)
• Changes in liver function tests

Following are the precautions and warnings for Ceftriaxone 500mg, Sulbactam 500mg injection:

• Not recommended for patients with a history of severe allergic reactions to penicillin or other beta-lactam antibiotics.
• Should be used with caution in patients with kidney or liver disease, as dosage adjustments may be necessary.
• Patients should be monitored for potential allergic reactions, and medical attention must be sought if any occur.
• Long-term use may lead to the development of superinfections or antibiotic-resistant bacteria.
• Elderly patients may be more susceptible to side effects, and dosage adjustments might be required.
• This medication should only be used during pregnancy or breastfeeding if clearly needed and under medical supervision.
• Ensure proper hydration during the treatment period to reduce the risk of kidney-related side effects.

Following are the drug interactions for Ceftriaxone 500mg, Sulbactam 500mg injection:

• Probenecid can decrease the elimination of Ceftriaxone, leading to increased serum levels and potential toxicity.
• Nephrotoxic drugs (e.g., aminoglycosides, loop diuretics) may enhance the nephrotoxic potential when used with Ceftriaxone.
• Concomitant use with other antibiotics like vancomycin or aminoglycosides may increase the risk of antibiotic-associated colitis.
• Sulbactam may reduce the efficacy of oral contraceptives, requiring alternative birth control methods.
• Calcium-containing solutions or products (e.g., calcium gluconate) must not be administered simultaneously with Ceftriaxone due to precipitation risk.
• Ceftriaxone may falsely elevate glucose readings with certain tests, affecting diabetes management.
• The use of anticoagulants with Ceftriaxone may increase the risk of bleeding.

Following are the food interactions for Ceftriaxone 500mg and Sulbactam 500mg injection:

• Alcohol intake should be avoided or limited during treatment as it may increase the risk of gastrointestinal issues and affect the absorption of Ceftriaxone.
• Grapefruit and grapefruit juice should be consumed with caution as they can inhibit the enzyme CYP3A4, potentially affecting the metabolism of Ceftriaxone and increasing its levels in the body.
• High-fat meals may slightly delay the absorption of Ceftriaxone, but it does not significantly impact its overall effectiveness.
• Maintain adequate hydration and ensure a balanced diet to support overall health during the course of treatment.
• Avoid excessive caffeine consumption as it may interact with Sulbactam, potentially affecting its effectiveness.
• Avoid consuming foods with live cultures, such as probiotic supplements or yogurt, within 2 hours of taking the medication as they may interfere with the antibiotic's action.
• There are no specific food restrictions with Sulbactam, but maintaining a healthy diet is recommended for overall well-being during treatment.
• Follow any dietary instructions provided by your healthcare professional for the duration of the medication course.

Ceftriaxone 500mg and Sulbactam 500mg injection should be stored in a controlled environment, preferably between 68°F and 77°F (20°C and 25°C), with brief excursions permitted between 59°F and 86°F (15°C and 30°C). Protect the injection from direct sunlight and moisture by keeping it in its original packaging until use. Do not freeze the medication as it may affect its potency. Once the injection is prepared, it should be used immediately, and any unused portion should be discarded properly. Dispose of the used injection equipment, such as needles and syringes, in a puncture-proof container according to local regulations. It is crucial to keep this medication out of the reach of children and pets to prevent accidental exposure.

Following are the quick tips for Ceftriaxone 500mg and Sulbactam 500mg injection:

• Administer the injection under medical supervision; do not self-inject.
• Ensure the injection is prepared and administered by a trained healthcare professional.
• Inform your doctor about allergies or medical conditions before receiving the injection.
• The injection is typically given intramuscularly or intravenously as directed by your doctor.
• Maintain the prescribed dosage and duration for maximum effectiveness.
• Report any unusual pain, redness, or swelling at the injection site to your healthcare provider.
• Store the injection as directed, away from direct sunlight and moisture.