Synkast 60ml Solution

Montelukast sodium 10mg liquid primarily exerts its therapeutic effects through selective antagonism of the cysteinyl leukotriene receptor, CysLT1. Leukotrienes are potent inflammatory mediators released by mast cells and other immune cells, playing a significant role in the pathophysiology of asthma and allergic rhinitis. By blocking the CysLT1 receptor, montelukast inhibits the actions of leukotrienes, including bronchoconstriction, increased vascular permeability, and mucus secretion in the airways. This mechanism leads to decreased inflammation and improved respiratory function, making montelukast effective in managing asthma and alleviating symptoms associated with seasonal allergies.

Leukotriene receptor antagonist.

Solution

The following are the uses of Montelukast sodium 10mg Liquid:

• Used for preventing and treating asthma in adults and children.
• Used to relieve symptoms of seasonal allergies, like hay fever.
• Used to reduce the inflammation and swelling in the airways.
• Used for managing exercise-induced bronchoconstriction.
• Used as a long-term control medication to prevent asthma attacks.
• Used to block the action of leukotrienes, substances that trigger asthma and allergy symptoms.
• Used for providing 24-hour relief from asthma and allergy symptoms.
• Used in both maintenance and preventive treatment strategies.

In the case of an overdose of Montelukast sodium 10mg Liquid, it is important to remain calm and seek medical advice promptly. Symptoms of an overdose may include drowsiness, agitation, and gastrointestinal issues. Do not induce vomiting unless instructed by a healthcare professional. Contact a healthcare provider or local poison control center for guidance, as they can provide specific instructions based on the patient's age, weight, and overall health. Timely medical intervention can effectively manage and mitigate the effects of an overdose.

In the case of a missed dose of Montelukast sodium 10mg Liquid, it is important to administer the medication as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume the medication without compromising its effectiveness. It's crucial to maintain a consistent dosing routine for the best therapeutic outcome.

To administer Montelukast sodium 10mg Liquid, measure the prescribed dose using an oral syringe or dosing cup, ensuring accuracy, and give it to the patient once daily, preferably in the evening, with or without food, following the dosage instructions provided by the healthcare professional.

Here are the conditions and situations when Montelukast sodium 10mg Liquid should not be used:

• Do not use in individuals with a known allergy or hypersensitivity to Montelukast or any other ingredients in the liquid formulation.
• Contraindicated in patients with a history of severe allergic reactions or anaphylaxis to aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs).
• Not suitable for individuals with a history of liver problems or liver disease.
• Should not be used if the patient is currently taking certain medications, such as phenobarbital, rifampin, or phenytoin, as these can affect the metabolism of Montelukast.
• Not recommended for patients with phenylketonuria, as some formulations may contain aspartame.
• Avoid using Montelukast liquid in patients with a history of mental health disorders, including depression, suicidal thoughts, or other psychiatric conditions.
• Do not use in children under 6 months of age due to insufficient data on safety and efficacy.

The side effects of Montelukast sodium 10mg Liquid may include:

• Headache
• Drowsiness or fatigue
• Upset stomach or diarrhea
• Nausea
• Respiratory infections (such as flu, common cold)
• Cough
• Allergic reactions (skin rash, itching)
• Difficulty sleeping

Following are the precautions and warnings for Montelukast Sodium 10mg Liquid:

• Avoid use if you are allergic to Montelukast or any other ingredients in the liquid.
• Consult your doctor if you have a history of liver or kidney disease, as Montelukast may require dosage adjustments.
• Do not consume alcohol while taking this medication, as it may increase the risk of side effects.
• Patients with phenylketonuria (PKU) should be cautious as the liquid may contain aspartame, a source of phenylalanine.
• Montelukast may cause mental health side effects; monitor for any changes in behavior or mood and seek medical advice if necessary.
• Not recommended for children under 6 months of age.
• If you are pregnant or breastfeeding, consult your healthcare provider before taking this medication.
• Always follow the prescribed dosage and do not exceed the recommended duration of treatment.

Following are the drug interactions for Montelukast sodium 10mg Liquid:

• Concomitant use with strong CYP3A4 inducers like rifampin can decrease Montelukast blood levels, potentially reducing its effectiveness.
• The effectiveness of Montelukast may be reduced when taken with phenobarbital, a CYP450 inducer.
• Erythromycin, a CYP3A4 inhibitor, can increase Montelukast plasma concentrations.
• Ketoconazole, a potent CYP3A4 inhibitor, may increase Montelukast exposure, warranting caution in combined use.
• Theophylline levels can be slightly increased when co-administered with Montelukast.
• Montelukast may increase the bioavailability of certain medications, such as oral Midazolam, which is metabolized by CYP3A4.
• Warfarin and other anticoagulants may require dosage adjustments when used with Montelukast due to potential changes in blood clotting.

Following are the food interactions for Montelukast Sodium 10mg Liquid:

• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Montelukast, potentially increasing its levels in the body and altering its effectiveness.
• Alcohol intake is generally not recommended for individuals taking Montelukast, especially for those with a history of liver disease or other medical conditions.
• Avoid high-fat meals as they can delay the absorption of Montelukast, potentially reducing its effectiveness.
• Dairy products like milk or yogurt can be consumed but may slightly decrease the absorption of the medication. Consider taking the medication 1-2 hours before or after dairy intake.
• Avoid excessive consumption of caffeine-containing beverages as they may interact with Montelukast, potentially increasing heart rate and blood pressure.
• Avoid eating large amounts of cruciferous vegetables like broccoli and cauliflower, as they may slightly alter the drug's metabolism.
• It is advisable to maintain a balanced diet and stay well-hydrated while taking Montelukast to support overall health and medication effectiveness.
• Always consult your healthcare provider for personalized advice on dietary considerations related to Montelukast therapy.

Montelukast sodium 10mg liquid should be stored in a controlled environment, preferably at room temperature (around 25°C), in a dry and cool location. Protect the medication from direct sunlight and moisture to maintain its integrity. Keep the bottle tightly sealed to prevent contamination and ensure its effectiveness. When disposing of unused or expired medication, avoid flushing it down the toilet or sink. Instead, consult your local pharmacy or healthcare professional for guidance on proper disposal methods to ensure environmental safety. Keep the medication away from children and pets to prevent accidental ingestion.

Following are the quick tips for Montelukast Sodium 10mg Liquid:

• Always read the medication label and follow your doctor's instructions for the best results.
• Measure the liquid accurately using the provided measuring device.
• Take the medication at the same time each day to maintain a consistent routine.
• Store the liquid at room temperature, away from direct sunlight and moisture.
• Do not freeze the medication.
• If you experience any unusual symptoms or allergic reactions, seek medical attention promptly.
• Inform your doctor about all the medications you are taking to avoid potential interactions.
• Dispose of any unused or expired medication properly, following local guidelines.