SYTRON SYP

Sodium Ironedetate, also known as sodium ferric gluconate complex or iron(III)-hydroxydextrose, is a medication used to treat iron deficiency anemia. Its mechanism of action involves the replenishment of iron stores in the body. When administered orally, sodium ironedetate dissociates into iron (Fe3+) and other compounds in the gastrointestinal tract. The iron then undergoes a series of chemical reactions and is converted to its absorbable ferrous (Fe2+) form. This ferrous iron is transported across the intestinal wall into the bloodstream, where it binds to transferrin, a protein responsible for carrying iron to various tissues. Once inside the cells, iron is utilized in the synthesis of hemoglobin, the oxygen-carrying component of red blood cells, thereby improving anemia and restoring iron levels in the body.

Iron supplement

Suspension

The following are the uses of Sodium Ironedetate Syrup/Suspension:

• Used for treating iron deficiency anemia, especially in patients with poor oral iron absorption or those who cannot tolerate oral iron supplements.
• Used for replenishing iron stores in the body, ensuring adequate iron levels for healthy red blood cell production.
• Used for managing iron deficiency during pregnancy, ensuring the developing fetus receives sufficient iron for growth.
• Used for improving athletic performance and reducing fatigue in individuals with proven iron deficiency.
• Used for managing chronic iron deficiency due to conditions like gastrointestinal bleeding or malabsorption syndromes.
• Used for enhancing cognitive function and energy levels in individuals with iron deficiency-related fatigue and cognitive impairment.
• Used for preparing patients for major surgeries or medical procedures where blood loss is expected, ensuring better oxygen-carrying capacity.

In the case of an overdose of Sodium Ironedetate Syrup/Suspension, the severity of symptoms can vary. Gastrointestinal distress, including nausea, vomiting, and abdominal pain, may occur. More serious effects could lead to circulatory collapse, shock, and potentially organ damage. Prompt medical intervention is necessary to manage the symptoms and prevent further complications. It is crucial to seek medical advice immediately if an overdose is suspected.

In the case of a missed dose of Sodium Ironedetate Syrup/Suspension, it is important to administer the medication as soon as you remember. However, if it is almost time for the next scheduled dose, it is best to skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume the medication and maintain its effectiveness.

To administer Sodium Ironedetate Syrup/Suspension, shake the bottle vigorously before each use, and then measure the prescribed dose accurately using a suitable measuring device like a measuring spoon or oral syringe; take the syrup/suspension once daily, either with or without food, following the dosage instructions provided by your healthcare professional or as indicated on the medication label, ensuring adherence to the recommended dosage guidelines.

Here are the situations when Sodium Ironedetate Syrup/Suspension should not be used:

• Not suitable for patients with a known allergy or hypersensitivity to Sodium Ironedetate or any of its ingredients.
• Contraindicated in patients with iron overload disorders such as hemochromatosis, hemosiderosis, or hemolytic anemia.
• Should not be used in individuals with acute liver disease or severe kidney disease.
• Not recommended for patients with ongoing gastrointestinal bleeding or conditions that affect iron absorption.
• Avoid use in patients with untreated infections or inflammatory conditions, as it may interfere with iron metabolism.
• Contraindicated in patients with a history of anaphylactic reactions to iron products.
• Not suitable for individuals with a history of gastrointestinal surgery or conditions that may affect the digestive process.

The side effects of Sodium Ironedetate Syrup/Suspension may include:

• Nausea and vomiting
• Diarrhea or constipation
• Darkening of stools
• Abdominal pain or cramps
• Metallic taste in the mouth
• Tooth discoloration (when in contact with teeth)
• Allergic reactions (skin rash, itching, swelling)

Here are the precautions and warnings for Sodium Ironedetate Syrup/Suspension:

• Avoid using Sodium Ironedetate if you have a known allergy or hypersensitivity to iron or any of the excipients in the syrup/suspension.
• This medication should be used with caution in patients with gastrointestinal disorders, as it may cause gastrointestinal side effects such as nausea, vomiting, or constipation.
• Patients with a history of kidney disease or those currently experiencing kidney problems should exercise caution and consult a healthcare professional before use, as it may affect kidney function.
• Monitor blood glucose levels in diabetic patients, as Sodium Ironedetate may interfere with glucose metabolism.
• Sodium Ironedetate may cause temporary staining of teeth in children. Proper oral hygiene practices should be maintained to minimize this effect.
• Do not exceed the recommended dosage, as high doses of iron can be toxic and lead to serious health complications.
• Keep out of reach of children. In case of accidental overdose, seek immediate medical attention.
• Consult a healthcare professional before use if you are pregnant, planning to become pregnant, or breastfeeding.

Following are the drug interactions for Sodium Ironedetate Syrup/Suspension:

• Antacids containing aluminum, calcium, or magnesium can decrease the absorption of Sodium Ironedetate, reducing its effectiveness.
• Tetracycline antibiotics may have reduced absorption when taken with Sodium Ironedetate, so they should be taken at least 2 hours apart.
• Concomitant use with levothyroxine may interfere with its absorption, requiring monitoring of thyroid function.
• Sodium Ironedetate can decrease the effectiveness of certain antibiotics like ciprofloxacin and doxycycline.
• It may increase the risk of adverse effects when taken with medications that have a narrow therapeutic index, such as digoxin.
• Iron supplements can reduce the absorption of certain medications, including quinolone antibiotics and bisphosphonates.
• The syrup/suspension form may contain sugars or alcohol, which can interact with metronidazole, disulfiram, and certain antipsychotics.

Following are the food interactions for Sodium Ironedetate Syrup/Suspension:

• Avoid consuming antacids or dairy products within 2 hours of taking this medication, as they can decrease iron absorption.
• Do not consume tea or coffee with meals as they contain tannins that can reduce iron absorption.
• Citrus fruits like oranges, lemons, and grapefruit can enhance iron absorption due to their vitamin C content.
• Consuming iron-rich foods like red meat, poultry, fish, beans, and dark leafy greens alongside the medication can improve iron levels.
• Vitamin C supplements or foods rich in vitamin C, such as bell peppers, broccoli, and strawberries, can enhance iron absorption.
• Avoid alcohol consumption as it may interfere with iron absorption and worsen side effects.
• Certain foods like eggs, milk, and high-fiber foods can decrease iron absorption if consumed at the same time as the medication.

Sodium Ironedetate Syrup/Suspension requires careful storage and disposal to maintain its integrity and ensure safety. Store it in a cool, dry place, away from sunlight and moisture, preferably at room temperature. Keep the syrup tightly sealed in its original container to prevent contamination. Avoid extreme temperatures by not placing it near heat sources or in the bathroom. Regularly check the expiration date, and if expired or no longer needed, proper disposal is crucial. Do not dispose of it in sinks or toilets; instead, seek guidance from healthcare professionals or pharmacists for safe disposal methods. Always keep medications away from children to prevent accidental consumption.

Following are the quick tips for Sodium Ironedetate Syrup/Suspension:

• Always read the prescription label and follow your doctor's instructions for dosage.
• Shake the bottle vigorously before each use to ensure proper mixing.
• Administer the syrup/suspension orally, and use the provided measuring device for accurate dosing.
• Avoid mixing with other medications without consulting your pharmacist or doctor.
• Store in a cool, dry place, away from direct sunlight and moisture.
• Do not freeze the syrup/suspension.
• Discard any unused or expired medication as per local guidelines.