TA BETHANECHOL 25MG TAB (LOOSE)

Bethanechol 25MG Tablet, a cholinergic agonist, primarily exerts its effect by mimicking the action of acetylcholine, a neurotransmitter. It selectively binds to muscarinic receptors, particularly M1 and M3 subtypes, in the smooth muscles of the gastrointestinal tract and urinary bladder. Upon binding, bethanechol stimulates these receptors, leading to an increase in intracellular calcium levels. This rise in calcium triggers a series of events, including the activation of protein kinase C and the phosphorylation of myosin light-chain kinase, which ultimately results in smooth muscle contraction. This mechanism of action is particularly useful in treating certain gastrointestinal and urinary conditions where enhanced muscle tone or motility is desired, making it effective for managing postoperative and neurogenic ileus and urinary retention.

Bethanechol 25MG

Cholinergic (muscarinic) agonist.

Tablet

The following are the uses of Bethanechol 25MG Tablet:

• Used for treating urinary retention, helping individuals empty their bladder when facing difficulty urinating.
• Used for gastroesophageal reflux management, aiding in reducing stomach acid and improving digestion.
• Used for postoperative and post-delivery cases to stimulate bowel movements and prevent constipation.
• Used for treating certain types of ulcers by enhancing gastric emptying and reducing acid exposure.
• Used for improving esophageal motility disorders, allowing better food passage through the esophagus.
• Used for preventing and treating certain types of urinary incontinence by strengthening bladder control.
• Used for enhancing gastrointestinal motility, aiding in the movement of food through the digestive tract.
• Used for managing neurogenic bladder dysfunction, helping restore normal bladder function.

In the case of an overdose of Bethanechol 25MG Tablets, it is important to recognize the signs and act swiftly. Symptoms may include severe nausea, vomiting, diarrhea, and abdominal pain. Promptly seek medical assistance and provide healthcare professionals with information regarding the quantity ingested. Treatment for overdose may involve managing these symptoms and providing supportive care, ensuring the patient's safety and well-being.

In the case of a missed dose of Bethanechol 25MG Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication without affecting its efficacy. It is generally recommended to take the missed dose as soon as possible to maintain consistent medication levels in your body.

To take Bethanechol 25MG Tablet, swallow the tablet whole with a glass of water, preferably on an empty stomach, exactly as directed by your healthcare professional, typically 1 hour before or 2 hours after meals, three to four times a day.

Following are the conditions when Bethanechol 25MG Tablet should not be taken:

• Should not be used in patients with known allergy or hypersensitivity to Bethanechol or any of its ingredients.
• Contraindicated in individuals with mechanical obstruction of the gastrointestinal tract, as it can worsen the condition.
• Not recommended for patients with active peptic ulcer or bleeding from the digestive system.
• Should not be used in patients with severe cardiac conditions such as recent myocardial infarction or severe arrhythmias.
• Contraindicated in individuals with uncontrolled asthma or chronic obstructive pulmonary disease (COPD).
• Not suitable for patients with a history of urinary tract obstruction or bladder outlet obstruction.
• Should not be used during active asthma attacks or during periods of acute angle-closure glaucoma.
• Contraindicated in individuals with a history of hypersensitive pulmonary disease.
• Should be avoided in patients with hyperthyroidism or thyrotoxicosis due to increased risk of adverse effects.
• Not recommended for use during pregnancy, especially during the first trimester, unless the potential benefits outweigh the risks.

The side effects of Bethanechol 25MG Tablet may include:

• Increased saliva production
• Excessive sweating
• Watery eyes
• Nausea and vomiting
• Diarrhea
• Abdominal cramps
• Blurred vision
• Increased heart rate

Following are the precautions and warnings for Bethanechol 25MG Tablet:

• This medication should be used with caution in patients with a history of asthma, Parkinson's disease, or epilepsy, as it may worsen these conditions.
• Patients with gastrointestinal conditions such as ulcers, gastrointestinal bleeding, or mechanical obstruction should exercise caution as Bethanechol may exacerbate these issues.
• Individuals with cardiovascular problems, especially bradycardia (slow heart rate), should be closely monitored as the drug can affect heart rate.
• Elderly patients may be more susceptible to adverse effects, particularly related to the cardiovascular and nervous systems.
• It is important to avoid driving or operating heavy machinery until you know how this medication affects you, as it may cause blurred vision or dizziness.
• Inform your doctor if you have a history of kidney or liver disease, as they may need to adjust the dosage accordingly.
• This medication should not be used in patients with mechanical obstruction of the gastrointestinal or urinary tract, as it can lead to severe complications.

Following are the drug interactions for Bethanechol 25MG Tablet:

• Anticholinergic medications (e.g., atropine, scopolamine) may counteract the effects of Bethanechol, as they have opposite actions on the cholinergic system.
• The use of cholinesterase inhibitors like donepezil or rivastigmine along with Bethanechol can result in excessive cholinergic stimulation, leading to increased side effects such as nausea, vomiting, and diarrhea.
• Bethanechol may interact with certain antibiotics, including neostigmine and pyridostigmine, potentially causing additive cholinergic effects and exacerbating side effects.
• Caution is advised when combining Bethanechol with other medications that affect gastrointestinal motility, as it may alter the rate of gastric emptying and influence drug absorption.
• Drugs that slow the heart rate, such as beta-blockers or certain antiarrhythmic medications, may have an additive effect on heart rate when used with Bethanechol.
• The effects of Bethanechol may be reduced by medications that increase the acidity of the stomach, such as proton pump inhibitors or H2-receptor blockers.
• There is a potential for Bethanechol to interact with certain anesthetics, and its use should be carefully considered in patients undergoing surgical procedures.

Following are the food interactions for Bethanechol 25MG Tablet:

• Alcohol consumption should be avoided as it can increase side effects such as dizziness and blurred vision.
• Grapefruit and grapefruit juice should be consumed with caution as they may increase the effects of Bethanechol, potentially leading to increased side effects.
• Caffeine-rich foods and beverages like coffee, tea, and energy drinks should be limited as they can stimulate the nervous system and counteract the effects of the medication.
• High-fiber foods like whole grains, legumes, and vegetables are recommended to promote healthy digestion and prevent constipation.
• Spicy and acidic foods should be avoided as they can irritate the digestive system and worsen symptoms.
• Dairy products like milk and cheese should be consumed in moderation as they can potentially interact with Bethanechol, affecting its absorption.
• A balanced diet with adequate hydration is essential to support overall health and the medication's effectiveness.
• No specific food restrictions are associated with Bethanechol, but maintaining a healthy diet is advised for optimal results.

Bethanechol 25MG Tablets should be stored in a cool and dry place, preferably at room temperature between 68°F and 77°F (20°C and 25°C). Protect the tablets from excessive heat, moisture, and direct sunlight as these conditions can degrade the medication. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to air and humidity. It is crucial to dispose of any unused or expired medication properly by following local guidelines or consulting a pharmacist. Do not flush the tablets down the toilet or discard them into the trash without proper precautions, as this can pose environmental risks. Keep the medication out of the reach of children and pets to prevent accidental ingestion.

Following are the quick tips for Bethanechol 25MG Tablet:

• Take the tablet as directed by your doctor; do not crush or chew it.
• Consume the tablet with a full glass of water to aid swallowing.
• Maintain a consistent schedule by taking the tablet at the same time daily.
• Avoid alcohol consumption as it may interfere with the medication's effectiveness.
• Inform your doctor about all medications you're taking to prevent potential interactions.
• Store the tablets in a cool, dry place, away from sunlight and moisture.
• Do not share this medication with others, even with similar symptoms.