TA FLORINEF 100MCG TAB

Fludrocortisone Acetate, the active ingredient in the 100 Tablet formulation, acts as a potent mineralocorticoid. Its primary mechanism of action is to enhance the reabsorption of sodium and the excretion of potassium in the distal tubules of the kidneys. This is achieved by binding to mineralocorticoid receptors in the renal tubules, which stimulates the expression of epithelial sodium channels (ENaC) and increases sodium reabsorption. As a result, it promotes water retention, leading to increased blood volume and blood pressure. This mechanism is particularly beneficial in the treatment of conditions such as Addison's disease, where the body's natural production of mineralocorticoids is insufficient.

Fludrocortisone Acetate 100

Mineralocorticoid Steroid

Tablet

The following are the uses of Fludrocortisone Acetate 100 Tablet:

• Used for treating low levels of cortisol, a condition known as adrenocortical insufficiency, helping to restore hormone balance.
• Used for managing a specific type of low blood pressure called orthostatic hypotension, by increasing blood volume.
• Used for treating certain kidney conditions where the body loses excessive amounts of sodium, helping to regulate electrolyte balance.
• Used for managing a rare genetic disorder called congenital adrenal hyperplasia, aiding in hormone replacement.
• Used for providing short-term relief in various inflammatory and allergic conditions by reducing inflammation.
• Used for preventing and treating autoimmune conditions where the immune system attacks healthy tissues.
• Used for certain emergency situations, such as anaphylactic shock, to quickly raise blood pressure.

In the case of an overdose of Fludrocortisone Acetate 100 Tablets, individuals may experience symptoms such as increased blood pressure, fluid retention, and changes in mood or behavior. It is crucial to recognize the signs of overdose, which can include severe headaches, swelling in the legs or face, and extreme fatigue. If an overdose is suspected, seeking medical assistance promptly is vital to ensure appropriate treatment and prevent potential complications associated with excessive Fludrocortisone Acetate intake.

In the case of a missed dose of Fludrocortisone Acetate 100 Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance, as they may advise you to adjust the timing of your next dose or provide specific instructions to ensure you receive the correct amount of medication.

To take Fludrocortisone Acetate 100 Tablets, swallow the tablet whole with a glass of water, as directed by your doctor, usually once or twice a day, following the prescribed dosage and schedule provided by your healthcare professional.

Following are the conditions or situations when Fludrocortisone Acetate 100 Tablet should not be used:

• Should not be taken by individuals with a known allergy or hypersensitivity to Fludrocortisone Acetate or any other corticosteroids.
• Contraindicated in patients with systemic fungal infections.
• Not suitable for individuals with recent or active tuberculosis (TB) unless anti-tuberculous treatment is also provided.
• Should not be used to treat patients with severe liver disease, as it can lead to liver damage.
• Fludrocortisone is contraindicated in patients with recent intestinal ulcers, abscesses, or other intestinal issues.
• Should not be used for patients with recent heart attacks or those with severe heart failure.
• Not recommended for individuals with herpes simplex eye infections, as it can cause corneal perforation.
• Contraindicated in patients with a history of severe psychiatric disorders, including recent manic episodes.

The side effects of Fludrocortisone Acetate 100 Tablet may include:

• Increased appetite and weight gain
• Indigestion or heartburn
• Fluid retention and swelling (edema)
• Muscle weakness or wasting
• Mood changes, including irritability, anxiety, or depression
• Sleep disturbances
• Elevated blood pressure (hypertension)
• Skin thinning, bruising, or delayed wound healing

Following are the precautions and warnings:

• Fludrocortisone Acetate 100 Tablet should be used with caution in patients with high blood pressure, as it may cause fluid retention and worsen hypertension.
• Patients with heart problems, especially congestive heart failure, should be closely monitored as this medication can cause sodium retention and volume expansion.
• Regular monitoring of blood pressure, electrolyte levels, and body weight is essential during treatment.
• Diabetic patients should be aware that this medication can increase blood sugar levels and may require adjustments in diabetes medications.
• Prolonged use of Fludrocortisone Acetate may lead to osteoporosis, especially in older adults. Calcium and vitamin D supplements may be recommended to prevent bone loss.
• Patients should not abruptly stop taking this medication without medical supervision, as it can lead to adrenal insufficiency.
• It may cause immunosuppression, making patients more susceptible to infections. Avoid exposure to contagious diseases and inform your doctor if you develop any signs of infection.
• Consult your doctor if you have a history of liver disease, as this medication can affect liver function. Regular liver function tests may be necessary.

Following are the drug interactions for Fludrocortisone Acetate 100 Tablet:

• Fludrocortisone can increase the risk of hypokalemia when used with diuretics, especially potassium-wasting diuretics like furosemide.
• Combining with other corticosteroids may increase the risk of adrenal suppression and exacerbation of side effects.
• Drugs that induce or inhibit cytochrome P450 enzymes, such as rifampin or ketoconazole, can alter the metabolism of fludrocortisone.
• Anticoagulants like warfarin may have their effects enhanced by fludrocortisone, requiring close monitoring of coagulation parameters.
• The effectiveness of vaccines may be reduced when administered with fludrocortisone due to immunosuppression.
• Concomitant use with nonsteroidal anti-inflammatory drugs (NSAIDs) can increase the risk of gastrointestinal bleeding and ulceration.
• Fludrocortisone may increase blood pressure and interact with antihypertensive medications, requiring close monitoring.

Following are the food interactions for Fludrocortisone Acetate 100 Tablet:

• Avoid high-sodium foods like processed snacks, canned soups, and fast food. Excess sodium can interact with the medication and lead to fluid retention and high blood pressure.
• Potassium-rich foods such as bananas, oranges, spinach, and sweet potatoes should be included in the diet to maintain electrolyte balance.
• Limit caffeine intake from coffee, tea, and energy drinks as it may interact with Fludrocortisone and cause increased heart rate and nervousness.
• Alcohol can increase the risk of stomach bleeding and interact with the medication, so it's best to reduce or avoid alcohol consumption.
• Avoid grapefruit and grapefruit juice as they can affect the metabolism of Fludrocortisone, leading to increased medication levels in the body.
• Dairy products like milk and yogurt can be beneficial as they provide calcium, which is essential for bone health, especially when using corticosteroids.
• Maintain a balanced diet with whole grains, lean proteins, and healthy fats to support overall health while taking this medication.
• Always consult your healthcare provider for personalized dietary advice, especially if you have specific dietary restrictions or medical conditions.

Fludrocortisone Acetate 100 Tablet should be stored in a secure and dry location, preferably in its original container, at room temperature, away from moisture and heat sources. It is crucial to keep the medication away from direct sunlight as it can degrade its potency. Always check the expiration date, and if the tablets have expired, do not use them and dispose of them carefully. Proper disposal methods should be followed, avoiding flushing or pouring them into water sources. Keep the medication out of children's reach to prevent accidental consumption, and ensure responsible storage and disposal practices to maintain safety and effectiveness. It is essential to consult a pharmacist or healthcare professional for specific guidelines on medication disposal.

Following are the quick tips for Fludrocortisone Acetate 100 Tablet:

• Take the tablet as directed by your doctor, typically once or twice daily.
• Consume the tablet whole with a full glass of water, preferably in the morning.
• Maintain a consistent daily routine for taking the medication.
• Avoid abruptly stopping the medication; gradually reduce the dose as advised by your doctor.
• Regularly monitor your blood pressure and electrolyte levels while on this medication.
• Inform your doctor about all medications you are taking to prevent potential drug interactions.
• Store the tablets at room temperature, away from moisture and light.