TA GLUCANTIME 5ML INJ

GLUCANTIME Injection, containing the active ingredient meglumine antimoniate, exerts its therapeutic effect primarily through the activity of pentavalent antimony. The precise mechanism of action in the treatment of leishmaniasis is not fully understood, but it is believed to interfere with the metabolism of the parasite Leishmania. Inside the infected host cells, antimony is reduced to its trivalent form, which is thought to disrupt various cellular processes of the parasite. It may inhibit certain enzymes involved in energy production, DNA synthesis, and cell division, ultimately leading to the death of the Leishmania parasites. Additionally, it is suggested that antimony may enhance the host's immune response, contributing to the overall efficacy of the treatment.

GLUCANTIME

Antileishmanial agent

Injection

The following are the uses of GLUCANTIME Injection:

• Used for treating cutaneous leishmaniasis, a parasitic skin infection.
• Used for reversing the effects of certain types of drug-induced coma.
• Used for managing metabolic disorders related to phosphorus and calcium imbalances.
• Used for treating conditions like hypocalcemia (low calcium levels) and rickets.
• Used for regulating bone metabolism and mineralization processes.
• Used for preventing and treating bone diseases like osteoporosis.
• Used for supporting bone health and density, particularly in individuals with bone loss risks.
• Used for aiding in the healing and recovery of bone fractures.

In the case of an overdose of GLUCANTIME Injection, several symptoms may occur, including gastrointestinal disturbances, skin reactions, and neurological effects. The severity of these symptoms can vary based on the amount ingested. It is important to promptly seek medical assistance and provide the necessary information to healthcare professionals, including the dosage and timing of the overdose. Quick action can help mitigate potential complications and ensure appropriate treatment.

In the case of a missed dose of GLUCANTIME Injection, it is important to consult your healthcare provider for specific instructions. Generally, if you realize you have missed a dose, administer it as soon as possible, unless it is almost time for the next scheduled dose. However, do not double the dose to make up for a missed one, as this may increase the risk of side effects. Your healthcare provider may advise you to adjust the timing of subsequent doses to ensure the treatment remains effective.

To administer GLUCANTIME Injection, ensure proper aseptic technique, clean the injection site with an alcohol swab, and inject the prescribed dose subcutaneously or intramuscularly, following the recommended dosage schedule provided by your healthcare professional.

Following are the conditions or circumstances when GLUCANTIME Injection should not be administered:

• Allergic reaction • Should not be used if the patient has a known history of allergic reactions to meglumine antimoniate or any other components in the injection.
• Severe heart disease • Contraindicated in patients with severe cardiovascular disorders.
• Kidney impairment • Not recommended for individuals with severe kidney problems or kidney failure.
• Liver disease • Should not be administered to patients with severe liver impairment or active liver disease.
• During breastfeeding • It is contraindicated in women who are breastfeeding, as it may pass into breast milk.
• Recent myocardial infarction • Not suitable for patients who have recently had a heart attack.
• Severe respiratory disease • Should be avoided in individuals with severe respiratory conditions or breathing difficulties.
• Uncontrolled diabetes • Not recommended for patients with uncontrolled diabetes due to the risk of hypoglycemia.
• Central nervous system (CNS) disorders • Contraindicated in patients with severe CNS disorders or a history of seizures.
• Severe dehydration • Should not be used until the patient's hydration status is improved.
• Hypersensitivity to related compounds • Not suitable for individuals with known hypersensitivity to other antimonial compounds.

The side effects of GLUCANTIME Injection may include:

• Nausea and vomiting
• Diarrhea
• Abdominal pain
• Joint pain and muscle aches
• Skin reactions such as rash, itching, or redness at the injection site
• Fatigue and weakness
• Mild fever
• Headache

Following are the precautions and warnings for GLUCANTIME Injection:

• Patients with a history of allergies or sensitivity to meglumine antimoniate or other components of the injection should be closely monitored for any signs of allergic reactions.
• This medication may affect the heart, so patients with pre-existing cardiac conditions should be carefully monitored.
• GLUCANTIME can cause electrolyte disturbances, especially potassium and magnesium; regular monitoring is essential.
• Patients with kidney problems should be cautious as the injection may impact renal function.
• Regular assessment of liver function is recommended during prolonged treatment.
• Pregnant and breastfeeding women should use GLUCANTIME only if the potential benefits outweigh the risks, and under medical supervision.
• The safety and efficacy in children have not been established, and its use in this population should be determined by a healthcare professional.

Following are the drug interactions for GLUCANTIME Injection:

• Concomitant use with corticosteroids may lead to increased risk of adverse effects and should be closely monitored.
• Alcohol consumption should be avoided as it may reduce the effectiveness of the medication.
• The effectiveness of GLUCANTIME may be reduced when used with phenytoin, phenobarbital, or other anticonvulsants.
• Medications that lower the seizure threshold, such as bupropion or tricyclic antidepressants, can increase the risk of seizures when used with GLUCANTIME.
• Combining with chloroquine or mefloquine may result in increased toxicity and should be avoided.
• The drug's metabolism can be altered by macrolide antibiotics, potentially affecting its efficacy.
• Probenecid, a uricosuric agent, can decrease the renal excretion of GLUCANTIME, leading to increased drug levels.

Following are the food interactions to consider with GLUCANTIME Injection:

• Avoid alcohol consumption during treatment as it may increase the risk of side effects and negatively impact liver function.
• Grapefruit and grapefruit juice should be avoided as they can interfere with the metabolism of the drug, leading to increased drug levels in the body.
• Caffeine-rich foods and beverages should be limited as they may increase restlessness and anxiety, especially in high doses.
• High-fat meals can delay the absorption of the medication, potentially affecting its effectiveness.
• Dairy products like milk and cheese might reduce the absorption of the medicine; consider spacing out the intake of these foods.
• Avoid consuming large amounts of cruciferous vegetables like broccoli and cauliflower, as they can potentially affect the drug's metabolism.
• Spicy foods might increase the risk of gastrointestinal side effects, so it's advisable to moderate their consumption during treatment.
• Maintain a balanced diet rich in lean proteins, whole grains, and fresh fruits and vegetables to support overall health and aid in recovery.

Glucantime Injection should be stored and disposed of with utmost care to ensure safety and maintain its efficacy. Store the injection in a cool, dry place, preferably between 2°C and 8°C (refrigerator temperature) and protect it from light. Keep the injection in its original packaging to maintain sterility and prevent contamination. Do not freeze the medication as it may affect its potency. Dispose of any unused or expired Glucantime Injection through a medicine take-back program or by following local guidelines for hazardous waste disposal. Do not dispose of it in regular trash or pour it down the drain as it may cause environmental harm. Always keep medications out of the sight and reach of children and pets to prevent accidental exposure.

Following are the quick tips for GLUCANTIME Injection:

• Administer the injection under medical supervision; do not self-inject.
• Ensure the injection is prepared and administered by a trained healthcare professional.
• Inform your doctor about any allergies or medical conditions before receiving the injection.
• Avoid touching or reusing needles; dispose of them safely after use.
• Report any side effects or unusual symptoms immediately to your healthcare provider.
• Store the medication as directed on the package, away from direct sunlight and moisture.
• Do not share your medication with others, even if they have similar symptoms.