TA HISTOACRYL INJ (1S)

N-Butyl-2-Cyanoacrylate is a medical adhesive that forms a strong bond upon contact with tissue surfaces. The mechanism of action involves rapid polymerization when exposed to moisture or bodily fluids. The cyanoacrylate molecules undergo an anionic polymerization process, initiated by the presence of weak bases such as blood, tissue fluids, or moisture, resulting in the formation of long polymer chains. This polymerization creates a tight seal or barrier, providing hemostasis by adhering to the surrounding tissues and sealing off bleeding vessels. The adhesive properties of N-Butyl-2-Cyanoacrylate enable it to bond tissues together, promoting wound closure and supporting the natural healing process.

Cyanoacrylate adhesive

Injection

The following are the uses of N-Butyl-2-Cyanoacrylate2 Injection:

• Used for sealing and closing wounds, especially in emergency situations, due to its strong adhesive properties.
• Used for stopping bleeding by rapidly bonding tissues together.
• Used for repairing damaged skin and as an adjunct in skin grafting procedures.
• Used for sealing and protecting exposed dental roots and sealing cavities in dental applications.
• Used for securing and stabilizing surgical incisions during operations.
• Used for creating protective barriers and sealing punctures in various medical procedures.
• Used for adhering medical devices and instruments to the skin, ensuring they remain in place.

In the case of an overdose of N-Butyl-2-Cyanoacrylate2 Injection, it is important to seek medical assistance promptly. Overdoses may lead to severe adverse reactions, including skin and tissue damage at the injection site. Symptoms may include intense burning sensations, redness, and pain. Emergency treatment involves managing these symptoms, providing wound care, and ensuring proper ventilation to prevent respiratory distress.

In the case of a missed dose of N-Butyl-2-Cyanoacrylate2 Injection, it is essential to contact your healthcare provider for guidance. The course of action may vary depending on the specific medical condition being treated. Do not attempt to double the dose or administer it more frequently than prescribed. Your healthcare provider will provide instructions on how to proceed and may recommend rescheduling the missed dose or adjusting the remaining doses accordingly. It is crucial to follow their advice to ensure the treatment's effectiveness.

To administer N-Butyl-2-Cyanoacrylate2 Injection, clean the injection site with an antiseptic, insert the needle at a 90-degree angle, and slowly inject the prescribed amount, ensuring the entire dose is delivered subcutaneously as directed by your healthcare provider.

Following are the conditions/situations when N-Butyl-2-Cyanoacrylate Injection should not be administered:

• Must not be used in individuals with a known allergy or hypersensitivity to N-Butyl-2-Cyanoacrylate or any related compounds.
• Not suitable for use in patients with a history of anaphylactic reactions to any adhesives or acrylates.
• Contraindicated in areas where the skin is broken, such as open wounds or deep lacerations.
• Should not be used in cases of severe arterial bleeding.
• Avoid using near the eyes, ears, nose, mouth, or other mucous membranes.
• Not recommended for individuals with a history of skin disorders or conditions at the intended application site.
• Must not be used in individuals with a known or suspected esophageal foreign body, as it can cause complications.
• Contraindicated in patients with a history of pulmonary conditions, as it may cause respiratory distress if inhaled.

The side effects of N-Butyl-2-Cyanoacrylate Injection may include:

• Localized skin reactions such as itching, redness, and swelling at the injection site.
• Pain or burning sensation during or after the injection.
• Allergic reactions, including skin rash, itching, or hives.
• Breathing difficulties or wheezing.
• Swelling of the face, lips, or tongue.
• Anaphylaxis (a severe allergic reaction) in rare cases.
• Tissue damage if the injection is not administered correctly.
• Temporary skin discoloration or scarring at the injection site.

Following are the precautions and warnings for N-Butyl-2-Cyanoacrylate2 Injection:

• Not suitable for intravascular, subcutaneous, intramuscular, intrathecal, intraocular, or intra-articular injection; only for topical application.
• Must be used under medical supervision and administered by trained healthcare professionals.
• Ensure the injection site is clean and dry before application to prevent infection.
• Avoid contact with skin and eyes; immediate irrigation is necessary if accidental contact occurs.
• Keep out of reach of children; store in a secure location.
• Do not use if the solution appears discolored or contains particles.
• Individuals with a history of hypersensitivity or allergy to cyanoacrylate adhesives should not use this product.

Following are the drug interactions for N-Butyl-2-Cyanoacrylate2 Injection:

• Interaction with tissue plasminogen activators (tPA) may occur, as it can lead to reduced effectiveness of tPA in dissolving blood clots.
• Avoid using with anticoagulants like heparin or warfarin, as it may increase the risk of bleeding.
• The injection may interact with fibrinolytic agents, potentially causing uncontrolled bleeding.
• Use with caution when combined with antiplatelet drugs, as it can further increase the risk of bleeding and bruising.
• Certain medications like corticosteroids and nonsteroidal anti-inflammatory drugs (NSAIDs) can enhance the risk of skin reactions at the injection site.
• Interaction with local anesthetics is possible, leading to altered anesthesia effects.
• N-Butyl-2-Cyanoacrylate may increase the skin permeability of other drugs applied topically, potentially affecting their absorption and effectiveness.

Following are the food interactions for N-Butyl-2-Cyanoacrylate2 Injection:

• Avoid consuming alcohol during the treatment period as it can interfere with the adhesive properties of the glue and slow down the healing process.
• Grapefruit and grapefruit juice should be avoided as they may affect the absorption of certain medications, potentially impacting the effectiveness of the injection.
• Caffeinated beverages like coffee and tea might lead to increased blood flow, which could affect the glue's bonding, so it's best to limit their consumption.
• Spicy foods can cause sweating and increased skin temperature, potentially affecting the glue's adhesion, so it's advisable to minimize their intake.
• Foods high in vitamin C, such as citrus fruits and bell peppers, may influence the setting time of the adhesive; consider reducing their consumption before and after the procedure.
• Avoid dairy products as they might contain calcium, which can potentially interfere with the polymerization process of the cyanoacrylate glue.
• Limit the consumption of oily and greasy foods as they can leave residues on the skin, affecting the adhesion of the glue.

N-Butyl-2-Cyanoacrylate2 Injection should be stored in a controlled environment, specifically at room temperature, away from excessive heat, direct sunlight, and moisture. It is crucial to maintain a consistent temperature to ensure the stability of the injection. Keep the injection in its original packaging, tightly sealed, to prevent contamination and maintain its integrity. When disposing of any unused or expired injection, it is important to follow proper procedures. Do not dispose of it by flushing or pouring it down the drain; instead, consult your healthcare professional or pharmacist for safe disposal methods. Additionally, ensure that the injection is stored securely, out of the reach of children, to prevent accidental exposure.

Following are the quick tips for N-Butyl-2-Cyanoacrylate2 Injection:

• Ensure a medical professional administers the injection under sterile conditions.
• Check the expiration date before use and discard if expired.
• Verify the product's integrity and clarity; do not use if discolored or cloudy.
• Follow the prescribed dosage and injection site instructions provided by your healthcare provider.
• Avoid injecting into veins, arteries, or areas with poor blood circulation.
• If you experience any adverse reactions, seek immediate medical attention.
• Store the injection as directed on the packaging, typically at room temperature, away from direct sunlight.