TA HYDROCORTONE 20MG (30S)

Hydrocortisone tablets work by mimicking the effects of natural cortisol, a hormone produced by the adrenal glands. When administered, hydrocortisone binds to glucocorticoid receptors in various cells throughout the body. This binding activates the receptor, which then translocates to the cell nucleus, where it regulates gene expression. As a result, hydrocortisone reduces inflammation by suppressing the immune system's response, inhibiting the production of inflammatory mediators, and decreasing vascular permeability. It also has effects on metabolism, leading to increased blood glucose levels and the mobilization of fatty acids. The anti-inflammatory and immunosuppressive properties of hydrocortisone make it effective in managing various conditions where inflammation is a key component.

Hydrocortisone

Corticosteroid.

Tablet

The following are the uses of Hydrocortisone Tablet:

• Used for treating inflammatory bowel disease (IBD) and reducing inflammation in the digestive tract.
• Used for managing allergic reactions and reducing inflammation caused by allergies.
• Used for treating skin conditions like eczema and psoriasis by reducing redness and itching.
• Used for alleviating joint pain and swelling in conditions such as rheumatoid arthritis.
• Used for managing asthma symptoms by reducing airway inflammation.
• Used for treating adrenal insufficiency, a condition where the body produces insufficient cortisol.
• Used for suppressing the immune system in organ transplant patients to prevent rejection.
• Used for reducing inflammation and pain in various other inflammatory conditions as prescribed by a healthcare professional.

In the case of an overdose of Hydrocortisone Tablets, several symptoms may manifest. These include increased thirst, frequent urination, swelling in the lower legs and ankles, and muscle weakness. In severe cases, individuals may experience confusion, dizziness, and even seizures. Prompt medical intervention is necessary to manage these symptoms and prevent potential complications, with treatment focusing on providing supportive care and addressing the specific symptoms presented by the patient.

In the case of a missed dose of Hydrocortisone Tablets, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication regimen. Consult your healthcare provider if you have any concerns or questions regarding missed doses.

To take the Hydrocortisone Tablet, swallow the tablet whole with a full glass of water, following the prescribed dosage and timing instructions provided by your healthcare professional, typically taken once or twice a day, or as directed by your doctor.

Following are the conditions/situations when Hydrocortisone Tablet should not be used:

• Do not use if you are allergic to Hydrocortisone or any other steroid medications.
• Contraindicated in patients with systemic fungal infections.
• Should not be taken if you have a recent history of heart attack or severe heart disease.
• Avoid using it if you have an active tuberculosis infection.
• Not recommended for patients with gastrointestinal ulcers or recent bowel surgery.
• Do not use if you have an untreated infection or an untreated parasitic infection.
• Avoid using Hydrocortisone if you have a herpes eye infection or recent eye surgery.

The side effects of Hydrocortisone Tablet may include:

• Increased appetite and weight gain
• Nausea and vomiting
• Headache
• Dizziness or lightheadedness
• Sleep disturbances (insomnia or excessive sleepiness)
• Acne or skin rash
• Muscle weakness
• Mood changes, including irritability or anxiety

Following are the precautions and warnings:

• Hydrocortisone Tablets should not be used by individuals with a known allergy or hypersensitivity to hydrocortisone or any of the tablet's components.
• Long-term use or high doses may lead to adrenal suppression, so regular monitoring is necessary, especially when discontinuing treatment.
• Caution is advised for patients with gastrointestinal issues, as hydrocortisone can cause or exacerbate peptic ulcers.
• Patients with a history of psychiatric disorders should be closely monitored, as corticosteroids may induce or aggravate psychiatric symptoms.
• Elderly patients are more susceptible to corticosteroid-related side effects; therefore, lower dosages are recommended.
• Patients with infections should be monitored closely, as corticosteroids can mask the signs of infection and impede the healing process.
• Hydrocortisone can affect growth in children, so growth should be monitored during prolonged treatment.

Following are the drug interactions for Hydrocortisone Tablet:

• May reduce the effectiveness of immunosuppressants like ciclosporin and tacrolimus, requiring close monitoring.
• Can increase the risk of arrhythmias when used with cardiac glycosides like digoxin. Regular ECG monitoring is advised.
• Concomitant use with antidiabetic medications may necessitate adjustments in insulin or oral hypoglycemic doses due to increased glucose levels.
• May decrease the efficacy of anticoagulants such as warfarin, requiring more frequent monitoring of INR.
• The combination with diuretics can increase the risk of hypokalemia, especially with loop and thiazide diuretics.
• Hydrocortisone can increase the risk of gastrointestinal bleeding when taken with nonsteroidal anti-inflammatory drugs (NSAIDs).
• May interact with certain antidepressants, leading to increased side effects or reduced therapeutic effects.

Following are the food interactions to consider with Hydrocortisone Tablets:

• Avoid excessive salt intake, as Hydrocortisone can cause sodium retention, leading to increased blood pressure.
• Limit foods high in potassium like bananas, oranges, and tomatoes, as Hydrocortisone may cause potassium loss.
• Avoid high-sugar foods and beverages, especially if you have diabetes, as Hydrocortisone can increase blood sugar levels.
• Limit alcohol consumption, as it can increase the risk of stomach bleeding and interact with the medication's effects.
• Calcium-rich foods like dairy products should be consumed moderately, as Hydrocortisone can affect calcium absorption.
• Maintain a balanced diet with a variety of fruits, vegetables, and whole grains to support overall health while on Hydrocortisone treatment.
• Avoid grapefruit and grapefruit juice, as they can interfere with the metabolism of Hydrocortisone, altering its effectiveness.
• Stay hydrated by drinking plenty of water, as Hydrocortisone may cause fluid shifts and electrolyte imbalances.

Hydrocortisone tablets should be stored in a cool, dry place, preferably at room temperature between 68°F and 77°F (20°C and 25°C), and protected from light and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and effectiveness. It's crucial not to store them in the bathroom or near heat sources like ovens or radiators, as extreme temperatures can degrade the medication. Always check the expiration date, and if the tablets are expired or no longer needed, proper disposal is essential. Do not dispose of them in wastewater or household garbage; consult a pharmacist or healthcare professional for guidance on safe disposal methods, ensuring they are kept out of the reach of children to prevent accidental consumption.

Here are the quick tips for Hydrocortisone Tablet:

• Follow the recommended dosage instructions provided by your healthcare professional.
• Take the tablet with food or a glass of milk to reduce the risk of stomach irritation.
• Swallow the tablet whole; do not crush or chew it.
• Do not suddenly stop taking hydrocortisone without consulting your doctor, as it can lead to withdrawal symptoms.
• Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as hydrocortisone may affect these conditions.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.
• Keep the medication out of reach of children to prevent accidental consumption.
• Inform your doctor about any other medications or supplements you are taking to avoid potential interactions.