Marevan (5mg) 100 Tablets

Warfarin, a 5mg tablet, acts as an anticoagulant by inhibiting the synthesis of vitamin K-dependent clotting factors. It primarily targets the enzyme vitamin K epoxide reductase (VKOR), which is essential for the regeneration of active vitamin K. By blocking VKOR, warfarin disrupts the vitamin K cycle, leading to a reduced production of functional clotting factors II, VII, IX, and X. These clotting factors play a crucial role in the coagulation cascade, and their inhibition results in a prolonged clotting time. This mechanism effectively prevents the formation of blood clots, thereby reducing the risk of thromboembolic events such as stroke, pulmonary embolism, and deep vein thrombosis.

Anticoagulant

Tablet

The following are the uses of Warfarin 5mg Tablet:

• Used for preventing and treating harmful blood clots in conditions like deep vein thrombosis and pulmonary embolism.
• Used for reducing the risk of blood clots after certain types of surgery or during periods of prolonged immobility.
• Used for managing irregular heart rhythms like atrial fibrillation to prevent stroke.
• Used for long-term treatment to prevent blood clots in individuals with a history of recurrent clots.
• Used for conditions where there is an increased risk of clot formation due to genetic factors.
• Used for maintaining blood flow and preventing clots in patients with artificial heart valves.
• Used for balancing the body's clotting mechanism in specific medical situations.

In the case of an overdose of Warfarin 5mg Tablets, the severity of symptoms can vary. Common signs include excessive bleeding, such as nosebleeds, bleeding gums, and easy bruising. More serious effects may include internal bleeding, leading to chest pain, shortness of breath, and blood in urine or stool. Prompt medical intervention is vital, as overdoses can result in life-threatening complications. Patients should be closely monitored, and treatment may involve administering vitamin K and fresh frozen plasma to counteract the drug's effects.

In the case of a missed dose of Warfarin 5mg Tablet, it is important to take action promptly. If you realize you've missed a dose, take it as soon as possible on the same day. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one, as this may increase the risk of bleeding. It is advisable to set reminders or use a pill organizer to help you remember your daily doses and minimize the chances of missing them.

To take Warfarin 5mg Tablets, swallow the tablet whole with a full glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional, who will determine the appropriate dosage based on your medical condition and response to the medication.

Following are the conditions/situations when Warfarin 5mg Tablet should not be used:

• Should not be used in patients with known allergies to Warfarin or any of its ingredients.
• Contraindicated in individuals with bleeding disorders or active bleeding, including gastrointestinal bleeding, brain hemorrhage, or recent surgery.
• Not recommended for individuals with severe uncontrolled high blood pressure.
• Should not be used in pregnant women due to potential harm to the fetus.
• Avoid using Warfarin in patients with severe liver disease or impaired liver function.
• Contraindicated in individuals with a history of stroke or transient ischemic attack (TIA).
• Not suitable for patients with bacterial endocarditis or active infection.
• Should be used with caution and avoided if possible in patients with a history of blood clots in the legs (deep vein thrombosis) or lungs (pulmonary embolism) who are also at high risk of bleeding.
• Warfarin is not recommended for individuals with a recent history of spinal puncture or lumbar puncture.

The side effects of Warfarin 5mg Tablet may include:

• Easy bruising or bleeding (nosebleeds, bleeding gums, cuts that won't stop bleeding)
• Dark urine, pale stools, or jaundice (yellowing of the skin or eyes)
• Severe headache or dizziness
• Chest pain or difficulty breathing
• Weakness, numbness, or muscle pain
• Diarrhea or vomiting
• Skin rash or itching
• Hair loss

Following are the precautions and warnings for Warfarin 5mg Tablet:

• Warfarin should be used with caution in patients with a history of bleeding disorders, as it may increase the risk of bleeding.
• Regular monitoring of blood clotting time (INR) is essential to ensure the correct dosage and prevent excessive bleeding or clotting.
• Patients should maintain a consistent diet, as foods high in vitamin K can affect the drug's effectiveness. Avoid sudden changes in dietary habits.
• Inform your doctor about all medications, supplements, and herbal products you are taking, as many drugs can interact with Warfarin and affect its efficacy.
• Dental procedures or surgeries should be planned in consultation with your doctor to manage Warfarin dosage appropriately.
• Patients should be cautious about activities that carry a high risk of injury or bleeding, and wear protective gear when necessary.
• Warfarin is not recommended for use during pregnancy or breastfeeding, as it can cross the placenta and may cause harm to the fetus or newborn.

Following are the drug interactions for Warfarin 5mg Tablet:

• Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) can increase the risk of bleeding when taken with Warfarin.
• Certain antibiotics (e.g., erythromycin, clarithromycin) may enhance the effect of Warfarin, requiring close monitoring of INR levels.
• Antifungal medications like azole antifungals (e.g., ketoconazole) can increase Warfarin levels, necessitating dosage adjustments.
• Warfarin may interact with other anticoagulants (e.g., heparin, direct oral anticoagulants) and increase the risk of bleeding.
• Some antidepressants (e.g., selective serotonin reuptake inhibitors • SSRIs) may affect Warfarin's metabolism, requiring INR monitoring.
• Medications that affect vitamin K metabolism (e.g., vitamin K supplements, certain herbal products) can reduce Warfarin's effectiveness.
• Caution is advised when using Warfarin with drugs that affect liver function, as this may alter Warfarin's metabolism and response.

Following are the food interactions for Warfarin 5mg Tablet:

• Leafy green vegetables like spinach, kale, and broccoli should be consumed consistently as they are high in vitamin K, which is essential for blood clotting and can counteract the effects of Warfarin if levels fluctuate.
• Cranberry juice and products should be avoided as they may interfere with Warfarin's metabolism, potentially reducing its effectiveness.
• Consuming large amounts of garlic or garlic supplements may increase the risk of bleeding due to its antiplatelet properties, which can enhance Warfarin's effects.
• Vitamin K-rich foods like liver, soybeans, and green tea should be consumed with caution and consistently, as sudden changes in intake can affect blood clotting.
• Alcoholic beverages should be limited as alcohol can increase the risk of bleeding and may interact with Warfarin, potentially altering its effectiveness.
• Fish oil supplements and foods rich in omega-3 fatty acids should be consumed with caution as they may enhance Warfarin's blood-thinning effects.
• It is essential to maintain a consistent diet, and any significant changes in eating habits should be discussed with a healthcare provider to adjust Warfarin dosage accordingly.
• Always consult your healthcare provider for personalized dietary recommendations while taking Warfarin.

Warfarin 5mg Tablets should be stored in a secure and dry location, such as a medicine cabinet, away from direct sunlight, moisture, and heat. It is crucial to keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. Always check the expiration date on the packaging to ensure the medication is still effective and safe to use. When disposing of unused or expired tablets, do not flush them down the toilet or dispose of them in regular household waste. Instead, contact your local pharmacy or healthcare provider for guidance on proper disposal methods to protect the environment and public health. Keep the medication out of children's reach to prevent accidental consumption, as it can be harmful if ingested without medical supervision. Adhering to these storage and disposal guidelines ensures the safe handling and responsible management of Warfarin 5mg Tablets.

Following are the quick tips for Warfarin 5mg Tablet:

• Always take the tablet as directed by your doctor, usually once daily.
• Take it at the same time each day to maintain consistent blood levels.
• Warfarin can be taken with or without food, but taking it with food may reduce stomach upset.
• Do not crush or chew the tablet; swallow it whole with a full glass of water.
• Avoid alcohol as it may increase the risk of bleeding.
• Inform your doctor about all medications and supplements you take.
• Regular blood tests are necessary to monitor the drug's effectiveness and adjust dosage.
• Keep this medication in a safe place, away from children and pets.