Plaquenil (200mg) 30 Tablets

Hydroxychloroquine 200mg Tablet primarily exerts its therapeutic effects through several mechanisms of action. One of its primary actions is inhibiting the production and release of inflammatory cytokines, such as interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha), which are key mediators in the inflammatory process. By suppressing these cytokines, hydroxychloroquine helps reduce inflammation and alleviate symptoms associated with autoimmune and inflammatory conditions. Additionally, it interferes with the processing and presentation of antigens, thereby modulating the immune response and reducing the activation of immune cells. Hydroxychloroquine also exhibits immunomodulatory effects by influencing the pH within specific cellular compartments, which can impact the activity of immune cells and their signaling pathways. This multifaceted mechanism of action contributes to the drug's effectiveness in managing various autoimmune and inflammatory disorders.

Hydroxychloroquine 200mg

Antimalarial, anti-inflammatory, immunomodulatory

Tablet

The following are the uses of Hydroxychloroquine 200mg Tablet:

• Used for treating rheumatoid arthritis and systemic lupus erythematosus.
• Used to manage symptoms like joint pain, swelling, and skin problems associated with these conditions.
• Used for reducing inflammation and pain in autoimmune disorders.
• Used to suppress overactive immune responses.
• Used for preventing and treating malaria, especially in areas with chloroquine-resistant strains.
• Used to control symptoms of light-sensitive skin conditions like porphyria cutanea tarda.
• Used for managing certain skin issues caused by sunlight exposure.
• Used in specific cases to treat juvenile idiopathic arthritis in children.

In the case of an overdose of Hydroxychloroquine 200mg Tablets, individuals may experience severe symptoms such as nausea, vomiting, and in extreme cases, cardiac problems. Overdosing can lead to an increased risk of retinal damage and cardiac toxicity. The severity of the symptoms depends on the amount ingested, and immediate medical intervention is necessary. Treatment may involve monitoring vital signs, administering activated charcoal, and providing supportive care to manage the symptoms and prevent further complications. Prompt medical care is essential to minimize the potential harm caused by an overdose.

In the case of a missed dose of Hydroxychloroquine 200mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, consult your healthcare professional for advice on how to safely resume your medication. It is advisable to set reminders or use a pill organizer to help you remember to take your medication as prescribed.

To take Hydroxychloroquine 200mg Tablet, swallow the tablet whole with a glass of water, preferably with or after a meal, as directed by your healthcare professional, usually once or twice daily.

Here are the conditions or situations when Hydroxychloroquine 200mg Tablet should not be used:

• Must not be used in patients with known allergy or hypersensitivity to hydroxychloroquine or related drugs.
• Not suitable for individuals with a history of vision changes or retinal problems.
• Should not be used in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency.
• Contraindicated in patients with known severe liver disease or liver failure.
• Avoid in patients with a history of heart rhythm problems or heart disease.
• Not recommended for individuals with a known blood disorder or low blood cell counts.
• Should not be used during pregnancy, especially in the last trimester, due to potential harm to the fetus.
• Not suitable for children under 6 years of age.

The side effects of Hydroxychloroquine 200mg Tablet may include:

• Nausea and vomiting
• Headache
• Dizziness
• Skin rashes or itching
• Changes in vision (e.g., blurred vision, difficulty focusing)
• Diarrhea
• Muscle weakness or cramps
• Hair loss

Here are the precautions and warnings for Hydroxychloroquine 200mg Tablet:

• This medication should not be used in patients with known hypersensitivity or allergy to Hydroxychloroquine or related compounds.
• Regular eye examinations are crucial during long-term treatment to detect any retinal changes promptly.
• Caution is advised in patients with liver or kidney disease, as dosage adjustments may be necessary.
• Hydroxychloroquine may cause severe hypoglycemia, especially in patients with diabetes or those receiving insulin therapy.
• It can exacerbate psoriasis and should be used with caution in such patients.
• This drug may cause muscle damage, so patients should be advised to report any unexplained muscle pain, tenderness, or weakness.
• Hydroxychloroquine may cause cardiac changes; regular monitoring is recommended, especially in patients with heart disease.
• Elderly patients may be more susceptible to the side effects of this medication.

Following are the drug interactions for Hydroxychloroquine 200mg Tablet:

• Antacids containing aluminum or magnesium can reduce the absorption of hydroxychloroquine, so take these medications at least 4 hours apart.
• Hydroxychloroquine may increase the blood levels of digoxin, leading to potential toxicity, so close monitoring is required.
• The risk of hypoglycemia may increase when used with insulin or antidiabetic drugs, requiring careful glucose monitoring.
• Combining with drugs that prolong the QT interval (e.g., certain antibiotics, antipsychotics) can further prolong this interval, increasing the risk of arrhythmias.
• Anticonvulsants like carbamazepine can decrease hydroxychloroquine levels, possibly reducing its effectiveness.
• Macrolide antibiotics (e.g., erythromycin) can increase hydroxychloroquine concentrations, raising the risk of adverse effects.
• Caution is advised with immunosuppressants, as hydroxychloroquine may enhance their effects, leading to increased immunosuppression.

Following are the food interactions for Hydroxychloroquine 200mg Tablet:

• Avoid excessive consumption of grapefruit and grapefruit juice as they may interfere with the medication's metabolism, leading to increased drug levels in the body.
• Alcohol should be consumed in moderation as it can enhance the risk of liver problems and may cause increased side effects.
• Foods rich in vitamin C, like citrus fruits and broccoli, may enhance iron absorption, which is important as Hydroxychloroquine can affect iron levels.
• Avoid high-fat meals as they may delay the absorption of Hydroxychloroquine, potentially reducing its effectiveness.
• Dairy products should be consumed with caution as some individuals may experience stomach upset or gastrointestinal issues when taking Hydroxychloroquine with dairy.
• Ensure adequate fluid intake, especially water, to prevent dehydration, which can be a concern with long-term use of Hydroxychloroquine.
• Avoid caffeine or reduce intake as it may interact with Hydroxychloroquine, potentially causing increased heart rate or nervousness.
• Consult your doctor or pharmacist about any specific dietary restrictions or recommendations tailored to your medical condition and medication regimen.

Hydroxychloroquine 200mg Tablets should be stored in a secure and dry location, preferably at room temperature (68°F to 77°F). Protect the tablets from excessive heat, moisture, or direct sunlight, as these conditions can degrade the medication. Keep the tablets in their original container, tightly sealed, to maintain their integrity and effectiveness. It is crucial to ensure that the medication is stored away from children and pets to prevent accidental consumption. When disposing of unused or expired tablets, do not throw them in the trash or flush them down the toilet. Contact your pharmacist or local waste management authorities for guidance on proper disposal methods to ensure environmental safety.

Following are the quick tips for Hydroxychloroquine 200mg Tablet:

• Take the tablet as directed by your doctor, typically 1-2 tablets daily or as prescribed.
• Swallow the tablet whole with a glass of water, do not crush or chew.
• Take the tablet with or after meals to minimize stomach irritation.
• Avoid taking antacids or indigestion remedies within 4 hours of this medication.
• Inform your doctor if you have any eye or vision changes during treatment.
• Regular eye exams are recommended while on this medication.
• Store the tablets in a cool, dry place, away from direct sunlight.