TA QUESTRAN SACHETS

Colestyramine sachet works through a process called bile acid sequestration. When ingested, it binds to bile acids in the intestine, which are produced by the liver from cholesterol. Normally, bile acids are reabsorbed and recycled by the body, but Colestyramine forms a strong complex with these bile acids, preventing their reabsorption. As a result, the liver is stimulated to convert more cholesterol into bile acids to compensate for the loss, which ultimately lowers the levels of cholesterol in the blood. This mechanism makes Colestyramine effective in reducing low-density lipoprotein (LDL) cholesterol, often referred to as "bad" cholesterol, thereby helping to manage conditions like hyperlipidemia and hypercholesterolemia.

Bile acid sequestrant.

powder

The following are the uses of Colestyramine Sachet:

• Used for lowering high cholesterol levels in the blood.
• Used for treating diarrhea by reducing excess bile acids.
• Used to relieve itching caused by a build-up of bile acids in liver disease.
• Used for managing diarrhea associated with gastrointestinal surgery.
• Used post-operatively to reduce bile salt absorption.
• Used for long-term management of diarrhea-predominant irritable bowel syndrome.
• Used for the relief of chronic diarrhea due to bile acid malabsorption.

In the case of an overdose of Colestyramine Sachet, it is important to recognize the signs and take appropriate action. Symptoms may include gastrointestinal issues such as constipation, bloating, or nausea. If an overdose is suspected, seek medical advice promptly. Treatment may involve managing symptoms and providing supportive care. It is crucial to store and administer medications as directed to prevent accidental overdoses.

In the case of a missed dose of Colestyramine Sachet, it is important to take the prescribed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance, as they may advise you to restart the medication or adjust the dosage accordingly. It is essential to follow your doctor's instructions to ensure the medication's effectiveness.

To take Colestyramine Sachet, open the sachet and mix the powder with 3 to 6 ounces of water or other suitable liquid, stir well until it forms a smooth mixture, and drink the entire mixture immediately after preparation, ensuring you follow the prescribed dosage and timing instructions provided by your healthcare professional.

Following are the conditions or situations when Colestyramine Sachet should not be used:

• Avoid using if you have a known allergy or hypersensitivity to Colestyramine or any of its ingredients.
• Do not take if you have complete bowel obstruction or severe constipation.
• Contraindicated in individuals with phenylketonuria, as some brands may contain aspartame.
• Not suitable for patients with severe gastrointestinal ulceration or bleeding.
• Should not be used in patients with severe renal impairment or kidney disease.
• Avoid if you have severe hyperchloremic acidosis.
• Do not administer to infants with hyperbilirubinemia.

The side effects of Colestyramine Sachet may include:

• Constipation
• Nausea and vomiting
• Abdominal pain or cramps
• Diarrhea
• Loss of appetite
• Fatigue and weakness
• Skin rash or itching
• Increased risk of gallstones

Following are the precautions and warnings for Colestyramine Sachet:

• Not suitable for individuals with a known allergy to Colestyramine or any of its ingredients.
• Patients with kidney problems should use with caution and under medical supervision, as it may need dosage adjustments.
• May interfere with the absorption of other medications; therefore, take other medications at least 1 hour before or 4 hours after Colestyramine.
• Can cause constipation; patients should ensure an adequate intake of fluids and fiber to minimize this risk.
• Patients with phenylketonuria should be aware that some Colestyramine products may contain phenylalanine.
• Not recommended for long-term use without medical supervision due to potential vitamin and mineral deficiencies.
• Pregnant and breastfeeding women should consult their doctor before using this medication as it may affect fetal development and pass into breast milk.

Following are the drug interactions for Colestyramine Sachet:

• Colestyramine can bind to other medications, reducing their absorption, including warfarin, digoxin, and some antibiotics like tetracyclines and fluoroquinolones.
• The absorption of oral hypoglycemic drugs, such as metformin, may be decreased when taken with Colestyramine, potentially affecting blood sugar control.
• Thyroid replacement medications like levothyroxine may have reduced absorption when taken with Colestyramine, requiring a dose adjustment.
• It can also bind to some diuretics (e.g., thiazide diuretics) and anti-seizure medications, affecting their effectiveness.
• Colestyramine may decrease the absorption of some vitamins, particularly fat-soluble vitamins (A, D, E, and K), requiring supplementation.
• It may interfere with the absorption of calcium supplements, which could be problematic for individuals with osteoporosis or calcium deficiency.
• Caution is advised when using Colestyramine with other medications that lower cholesterol, as it may increase the risk of adverse effects.

Following are the food interactions to consider with Colestyramine Sachet:

• Colestyramine can bind to dietary fats, including fat-soluble vitamins (A, D, E, and K), reducing their absorption. It's advisable to maintain a balanced diet and consider vitamin supplements if necessary.
• Avoid consuming foods high in cholesterol and saturated fats as they can counteract the medication's effect.
• Ensure an adequate fluid intake, as Colestyramine can cause constipation and may require additional hydration.
• Grapefruit juice should be avoided as it can interfere with the metabolism of certain medications, potentially affecting their effectiveness.
• Limit alcohol consumption as it can increase the risk of liver problems, especially in individuals with existing liver conditions.
• Avoid or limit high-fiber foods like whole grains, legumes, and certain vegetables immediately after taking Colestyramine, as they can interfere with the medication's binding action.
• Dairy products, particularly milk and yogurt, can be consumed but may be best taken at least one hour before or after Colestyramine to ensure optimal medication effectiveness.

The storage and disposal of Colestyramine Sachet require specific attention to maintain its effectiveness and ensure safety. Store Colestyramine Sachets in a cool, dry place, preferably at room temperature, ensuring it remains protected from sunlight and moisture. Keep the sachets in their original packaging, tightly sealed to maintain their integrity. Avoid exposure to heat sources like radiators or ovens, as temperature fluctuations can impact the medication's quality. Regularly check the expiration date, and if the sachets are past their expiry, dispose of them promptly. When disposing of Colestyramine Sachet, refrain from flushing it down the toilet or pouring it into drainage systems. Consult your pharmacist or healthcare professional for guidance on proper disposal methods to minimize environmental impact. Keep the medication securely stored, out of children's reach, to prevent accidental consumption.

Following are the quick tips for Colestyramine Sachet:

• Mix the powder from the sachet with water or other suitable liquids as directed by your doctor or pharmacist.
• Stir the mixture well until it forms a smooth consistency before consuming.
• Ensure you drink plenty of fluids throughout the day when taking this medication.
• Avoid taking this medication with other oral medications as it may interfere with their absorption.
• If you miss a dose, take it as soon as you remember, unless it's almost time for your next dose.
• Do not double the dose to make up for a missed one.
• Store the sachets in a cool, dry place, away from direct sunlight and moisture.