TA SORANIB 200MG TAB

TA SORANIB 200MG TAB

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  • Manufacturer IMPORTED PHARMACEUTICALS (PVT.) LTD.
  • Generic Name Sorafenib

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Description

    Sorafenib 200MG Tablet, a multi-kinase inhibitor, exerts its effects by targeting multiple enzymes and signaling pathways involved in tumor growth and angiogenesis. It primarily inhibits the activity of various kinases, including RAF kinase, VEGFR (vascular endothelial growth factor receptor), PDGFR (platelet-derived growth factor receptor), and FLT-3 (FMS-like tyrosine kinase 3). By blocking RAF kinase, Sorafenib inhibits the MAPK (mitogen-activated protein kinase) signaling pathway, which is crucial for cell proliferation and survival in cancer cells. Additionally, its inhibition of VEGFR and PDGFR reduces the formation of new blood vessels within tumors, restricting their growth and spread. Sorafenib's ability to target FLT-3 also contributes to its anti-cancer properties, as this kinase is often involved in the development and progression of certain types of cancer.

  • Ingredients

    Sorafenib
  • Drug Class

    Kinase inhibitor.

  • Dosage Form

    Tablet

  • Uses

    The following are the uses of Sorafenib 200MG Tablet:

    • Used for treating advanced kidney cancer that has not responded to other treatments.
    • Used in liver cancer cases where the cancer cannot be removed surgically.
    • Used to manage advanced thyroid cancer, especially in radioactive iodine-resistant cases.
    • Used as a treatment option for certain types of advanced or metastatic differentiated thyroid carcinomas.
    • Used for managing advanced or unresectable gastrointestinal stromal tumors (GISTs).
    • Used in rare cases of advanced or metastatic soft tissue sarcomas, providing a targeted treatment approach.
    • Used as a targeted therapy for specific types of cancer, offering an alternative to traditional chemotherapy.
    • Used in certain cancer cases to improve survival rates and manage symptoms.
  • In case of Overdose

    In the case of an overdose of Sorafenib 200MG Tablet, it is important to recognize the potential severity of this situation. Overdosing on this medication can lead to serious side effects and health complications. Symptoms may include severe gastrointestinal issues, such as persistent vomiting or diarrhea, as well as liver function abnormalities. If an overdose is suspected, immediate medical intervention is necessary to manage symptoms and prevent potential long-term damage to the body. Prompt action can help mitigate the risks associated with this medication.

  • Missed Dose

    In the case of a missed dose of Sorafenib 200MG Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely adjust your dosing schedule and ensure optimal treatment.

  • How To Use

    To take Sorafenib 200MG Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, either with or without food, as directed by your healthcare professional, ensuring you adhere to the prescribed dosage and treatment duration.

  • When Not to Use

    Here are the situations when Sorafenib 200MG Tablet should not be used:

    • Do not take if you have a known allergy to Sorafenib or any other component in the tablet.
    • Avoid if you have a severe liver disease or impaired liver function.
    • Not suitable for individuals with severe or uncontrolled high blood pressure.
    • Should not be used during pregnancy as it may harm the unborn baby.
    • Do not breastfeed while taking this medication.
    • Not recommended for individuals with a history of blood clots or stroke.
    • Avoid if you have a heart disease or have had recent heart attack.
    • Do not take if you have severe kidney disease or are on dialysis.
    • Contraindicated in patients with a bleeding disorder or a history of stomach ulcers.
    • Not suitable for individuals with severe or untreated infections.
  • Side Effects

    The side effects of Sorafenib 200MG Tablet may include:

    • Fatigue and weakness
    • Nausea and vomiting
    • Diarrhea or constipation
    • Loss of appetite
    • Skin rash or itching
    • Hand-foot syndrome (tingling or redness in palms and soles)
    • Hair loss
    • High blood pressure
  • Precautions & Warnings

    Following are the precautions and warnings for Sorafenib 200MG Tablet:

    • Patients with a history of heart disease, hypertension, or cardiac issues should use this medication with caution, as it may worsen these conditions.
    • Regular monitoring of blood pressure is necessary during treatment, and adjustments in dosage may be required.
    • Sorafenib can cause liver problems; liver function tests should be performed periodically to monitor liver health.
    • Patients with kidney disease or a history of kidney issues should exercise caution and consult a doctor, as the medication may affect kidney function.
    • Avoid using Sorafenib during pregnancy or breastfeeding unless clearly necessary; it may harm the fetus or infant.
    • This medication may cause severe bleeding, especially in patients with a history of bleeding disorders or those taking anticoagulants.
    • Sorafenib can lead to the development of a second cancer; regular monitoring and immediate reporting of any new lumps or growths are essential.
    • Patients may experience severe skin reactions; any unusual skin changes should be reported to the doctor.
  • Drug Interactions

    Following are the drug interactions for Sorafenib 200MG Tablet:

    • Co-administration with strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) can significantly increase Sorafenib concentrations, potentially leading to increased toxicity.
    • CYP3A4 inducers (such as rifampicin, St. John's Wort) may decrease Sorafenib plasma levels, reducing its efficacy.
    • Sorafenib may enhance the anticoagulant effects of warfarin and other vitamin K antagonists, requiring close monitoring of INR and dose adjustments.
    • When combined with certain antihypertensive agents, Sorafenib can cause additional blood pressure reduction, necessitating blood pressure monitoring.
    • The use of Sorafenib with other drugs known to prolong QT intervals (e.g., certain antiarrhythmic medications) may increase the risk of cardiac arrhythmias.
    • Caution is advised when combining Sorafenib with immunosuppressants, as it may increase the risk of infections and exacerbate immunosuppression.
    • Sorafenib may increase the plasma concentrations of sirolimus, a substrate of CYP3A4 and P-gp, requiring close monitoring for sirolimus-related adverse effects.
  • Food Interactions

    Following are the food interactions for Sorafenib 200MG Tablet:

    • Grapefruit and grapefruit juice consumption should be avoided as they can increase Sorafenib levels in the blood, potentially causing increased side effects.
    • High-fat meals can affect the absorption of Sorafenib, so it is best to avoid fatty foods around the time of medication intake.
    • Alcohol may increase the risk of liver-related side effects, so it should be consumed in moderation or avoided during treatment.
    • Caffeine-rich beverages like coffee and tea might interfere with Sorafenib's metabolism; consider reducing intake.
    • Avoid consuming Seville oranges and starfruit as they can impact Sorafenib's breakdown in the body.
    • Keep a consistent intake of leafy green vegetables and foods rich in Vitamin K for stable blood clotting.
    • Inform your healthcare provider about dietary supplements as some may interact with Sorafenib.
  • Storage/Disposal

    Sorafenib 200MG Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area, away from direct sunlight and moisture. Keep the tablets in their original packaging, ensuring the container is tightly sealed to maintain its integrity and effectiveness. It's crucial not to expose the medication to extreme temperatures, so avoid storing it in the bathroom, near hot appliances, or in the refrigerator. Always check the expiration date, and if the tablets are past their expiry, dispose of them responsibly. Do not flush or pour them down the drain; instead, consult a pharmacist or healthcare professional for guidance on safe disposal methods. Keep the medication out of children's reach to prevent accidental consumption.

  • Quick Tips, if any

    Following are the quick tips for Sorafenib 200MG Tablet:

    • Take the tablet as directed by your doctor, typically twice daily.
    • Swallow the tablet whole with a full glass of water, do not crush or chew.
    • Consume the tablet on an empty stomach, at least 1 hour before or 2 hours after a meal.
    • Maintain a consistent schedule by taking it at the same times each day.
    • Avoid grapefruit and grapefruit juice during treatment.
    • Regularly monitor your blood pressure and report any changes to your doctor.
    • Store the tablets at room temperature, away from moisture and light.

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