TA XBIRA 250MG TAB (120S)

TA XBIRA 250MG TAB (120S)

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  • Manufacturer IMPORTED
  • Generic Name

    Abiraterone acetate 250MG

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Description

    Abiraterone acetate 250MG Tablet's primary mechanism of action involves potent and selective inhibition of CYP17A1, an enzyme crucial for androgen biosynthesis. By blocking CYP17A1, the medication suppresses the production of androgens in various tissues, including the testes, adrenal glands, and prostate tumor cells. This inhibition leads to a significant reduction in circulating testosterone and other androgens, which are essential for the growth and survival of prostate cancer cells. Abiraterone acetate specifically targets the conversion of precursor hormones, such as pregnenolone and progesterone, into androgens, thereby disrupting the androgen signaling pathway and inducing apoptosis in androgen-dependent prostate cancer cells.

  • Ingredients

    Abiraterone acetate 250MG

  • Drug Class

    Anti-androgen, CYP17A1 inhibitor.

  • Dosage Form

    Tablet

  • Uses

    The following are the uses of Abiraterone acetate 250MG Tablet:

    • Used for treating metastatic castration-resistant prostate cancer.
    • Used to block the production of androgens, reducing tumor growth.
    • Used as a second-line treatment option for advanced prostate cancer.
    • Used to improve survival rates and delay disease progression.
    • Used in combination with prednisone for optimal effectiveness.
    • Used to manage symptoms and improve quality of life.
    • Used as part of a comprehensive prostate cancer treatment plan.
  • In case of Overdose

    In the case of an overdose of Abiraterone acetate 250MG tablets, individuals may experience severe side effects, including an increased risk of liver problems, high blood pressure, and heart issues. Nausea, vomiting, and diarrhea are common symptoms of an overdose. If you suspect an overdose, seek medical advice promptly. Timely intervention is vital to manage potential complications and ensure appropriate treatment. It is important to act quickly and consult healthcare professionals for guidance.

  • Missed Dose

    In the case of a missed dose of Abiraterone acetate 250MG Tablet, it is important to take the medication as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. However, if you miss a dose and remember within a few hours, take the missed dose and then adjust the timing of your next dose accordingly. It is generally recommended to not double the dose to make up for a missed one. Always consult your healthcare provider if you have any concerns or questions regarding missed doses.

  • How To Use

    To take Abiraterone acetate 250MG Tablet, swallow the tablet whole with a full glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare provider.

  • When Not to Use

    Here are the conditions or situations when Abiraterone acetate 250MG Tablet should not be taken:

    • Do not take if you are allergic to abiraterone acetate or any of the other ingredients in the tablet.
    • Not suitable for individuals with severe liver impairment.
    • Contraindicated in women who are pregnant or breastfeeding.
    • Avoid if you have severe heart or blood vessel problems.
    • Do not take if you have an adrenal gland problem called Addison's disease.
    • Not recommended for individuals with severely low potassium or high calcium levels in the blood.
    • Should not be used if you have an uncontrolled infection.
    • Avoid if you have a history of heart attack or stroke.
    • Do not take this medication if you have severe liver problems or active liver disease.
  • Side Effects

    The side effects of Abiraterone acetate 250MG Tablet may include:

    • Fatigue and weakness
    • Joint or muscle pain
    • High blood pressure
    • Swelling in the legs or ankles
    • Hot flashes
    • Diarrhea
    • Decreased potassium levels
    • Elevated liver enzymes
  • Precautions & Warnings

    Following are the precautions and warnings for Abiraterone Acetate 250MG Tablet:

    • This medication is intended for use in males only and should not be used by women, especially those who are pregnant or breastfeeding, as it can cause harm to the developing fetus or newborn.
    • Patients with severe liver impairment should not take this medication due to potential liver toxicity.
    • Regular monitoring of liver function is necessary during treatment, and any signs of liver problems should be reported immediately.
    • Patients with adrenal insufficiency or a history of mineralocorticoid excess syndrome should exercise caution and be monitored closely.
    • It may cause hypertension, so blood pressure should be monitored regularly, and anti-hypertensive medications may be required.
    • Patients should be advised to maintain adequate fluid intake to reduce the risk of electrolyte abnormalities.
    • This medication can cause severe birth defects, so effective contraception is essential during treatment and for at least 3 weeks after stopping the medication.
    • Patients should be aware of the potential for drug interactions, especially with strong CYP3A4 inhibitors or inducers, which may require dosage adjustments.
  • Drug Interactions

    Following are the drug interactions for Abiraterone acetate 250MG Tablet:

    • Concomitant use with strong CYP3A4 inducers like rifampin or phenytoin can reduce abiraterone plasma concentrations, potentially decreasing its effectiveness.
    • Avoid combining with strong CYP2D6 inhibitors (e.g., paroxetine, fluoxetine) as it may increase abiraterone exposure and side effects.
    • Abiraterone may increase the concentration of medications metabolized by CYP1A2, such as theophylline and certain antipsychotics.
    • Use with caution alongside drugs that prolong QT interval, as abiraterone can also prolong QT interval, increasing the risk of arrhythmias.
    • It can increase the risk of bleeding when taken with anticoagulants like warfarin or antiplatelet drugs.
    • Avoid or monitor closely when used with potent CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin), as this can significantly increase abiraterone levels.
    • Abiraterone may interact with immunosuppressants, leading to increased immunosuppression and infection risk.
  • Food Interactions

    Following are the food interactions for Abiraterone acetate 250MG Tablet:

    • Avoid grapefruit and grapefruit juice as they can increase the levels of abiraterone in the blood, leading to potential liver toxicity.
    • Limit alcohol consumption as it can increase the risk of liver problems and worsen side effects like nausea and vomiting.
    • High-fat meals can increase the absorption of abiraterone, so consider taking the medication with a low-fat meal or on an empty stomach.
    • Avoid excessive consumption of salt-preserved foods, as they can affect electrolyte balance and blood pressure.
    • Patients with diabetes should monitor their sugar intake and adjust their diet as this medication may increase blood sugar levels.
    • Certain herbal supplements like St. John's Wort may interact with Abiraterone, so consult your doctor before taking any herbal products.
    • Avoid foods rich in vitamin K (like spinach, kale) as they can interfere with blood clotting when taken with this medication.
    • Follow a balanced diet and maintain hydration, as this medication may cause fluid retention and electrolyte imbalances.
  • Storage/Disposal

    Abiraterone acetate 250MG Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or designated storage area, away from direct sunlight, moisture, and heat. It is crucial to keep the tablets in their original packaging, ensuring the container is tightly sealed to maintain its integrity. When disposing of unused or expired tablets, avoid flushing them down the toilet or sink. Instead, follow local guidelines or consult your pharmacist for safe disposal methods to protect the environment. Always keep medications out of children's reach to prevent accidental consumption, and remember to regularly check the expiration date on the packaging.

  • Quick Tips, if any

    Following are the quick tips for Abiraterone acetate 250MG Tablet:

    • Take the tablet as directed by your doctor, typically once a day.
    • Consume the tablet on an empty stomach, at least one hour before or two hours after a meal.
    • Avoid eating grapefruit or drinking grapefruit juice during treatment.
    • Maintain a consistent daily routine for taking the medication.
    • If you miss a dose, skip it and continue with the next scheduled dose; do not double the dose.
    • Regularly monitor your blood pressure and report any significant changes to your doctor.
    • Inform your healthcare provider about all medications and supplements you are taking to ensure safe use.

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