Tagipmet-XR (50/500mg) 14 Tablets

Sitagliptin is a oral medication used to treat individuals with diabetes and is employed to regulate elevated blood sugar levels. It functions by stimulating the production of natural substances that absorb blood sugar, particularly when those levels are high. Sitagliptin belongs to a class of drugs called DPP-4 inhibitors, which are responsible for blocking the breakdown of a hormone called incretins, which helps to control blood sugar levels. Metformin Hydrochloride is also a drug used to treat individuals with diabetes, and it works differently than Sitagliptin. It belongs to a class of drugs called biguanides. It reduces the amount of glucose that the liver produces and makes the muscles more sensitive to glucose, which helps to reduce blood sugar levels. It's important to follow medical advice carefully and to consult with a medical professional prior to taking Metformin, as it may cause low blood sugar.

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Biguanide, DPP-4 Inhibitor

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Tablet

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Unveiling its multifaceted uses and transformative applications as follows:

• Sitagliptin is used with diet and exercise in adults with type 2 diabetes who cannot control their blood sugar on metformin alone or in those who are already taking the maximum tolerated dose of metformin.
• Metformin Hydrochloride is used to manage type 2 diabetes and to reduce the risk of developing complications such as blindness, strokes, heart attacks, and kidney problems.

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Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Take Sitagliptin 50mg- Take one tablet with or without food, once a day, at the same time every day. For adequate control of diabetes, the dosage should be adjusted accordingly based on self-monitoring of blood glucose levels and clinical response. The maximum recommended dose is 100mg per day.
• Take Metformin Hydrochloride 500mg- Take two tablets with or without food, once a day, at the same time every day
• It is important to adhere to the prescribed dosage and instructions given by your healthcare provider.

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An overdose of sitagliptin and metformin can potentially cause lactic acidosis, a dangerous condition that occurs when there is a buildup of lactic acid in the blood. Lactic acidosis can cause nausea, vomiting, weakness, and rapid breathing. It's crucial to seek immediate medical attention if you suspect someone has experienced an overdose. The treatment involves providing emergency respiratory support to improve blood oxygen levels, dialysis to filter and remove the toxic compounds from the blood, and addressing the underlying cause. It is essential to be aware of the symptoms and seek prompt medical attention if you or someone you know experiences an overdose of sitagliptin and metformin.

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If you happen to miss a dose of your medication, take the missed dose as soon as possible. However, if it is almost time for your next scheduled dose, simply skip the missed dose and continue on with your regular schedule. Under no circumstance should you double up on your dosage to make up for the missed dose. If you are unsure about what to do, it is best to contact your physician or pharmacist to determine the best course of action based on your personal circumstances. It is very important to follow these instructions carefully, as taking the correct dosage is crucial for your treatment plan. Let your doctor know if you experience any complications or side effects during your dosage.

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Both Sitagliptin 50mg and Metformin Hydrochloride 500mg are prescribed medications that should be taken under a physician's guidance.For Sitagliptin 50mg, it is usually recommended to take the medication once daily at the same time each day to maintain stable drug levels in your system. Whether you take it with or without food is not highly important, but you should stick to your physician's instructions. Metformin Hydrochloride 500mg should be taken orally, usually with meals to prevent an upset stomach. The prescribed dose varies depending on individual health conditions and how well the treatment responds to the patient. It is vital to follow the precise dosage instructions provided by your doctor. Remember not to crush or chew Metformin Hydrochloride tablets or capsules, as this can alter the intended release rate of the drug. Should you experience severe stomach discomfort or vomiting, it is essential to consult your doctor immediately, as they may recommend taking the medication with food or alternative treatment. Since alcohol can increase the risk of developing lactic acidosis (a dangerous buildup of lactic acid in the blood), it is best to avoid excessive alcohol consumption while taking Metformin Hydrochloride. When starting your treatment, inform your healthcare provider about all the medications you are currently taking, including over-the-counter drugs and dietary supplements, to ensure safety and avoid any potential interactions with Metformin Hydrochloride and Sitagliptin 50mg. Maintaining regular appointments with your doctor is also important to monitor your health and ensure that the medication is working effectively. Always read the patient information leaflet and ask your doctor or pharmacist any questions you may have. It is crucial to inform your healthcare provider of any allergies or pre-existing medical conditions you may have to ensure safe usage of these medications.

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Discerning instances where this medication may not be appropriate:

• These drugs are intended for the treatment of diabetes and should not be taken without medical supervision.
• Hypoglycemia (low blood sugar)
• Kidney problems or acute kidney injury
• Acid-base balance disorders - affecting the balance of the body's acid base.
• Hypersensitivity (allergy)
• Pancreatitis or pancreatic problems
• Intense vomiting or diarrhea 
• In cases of severe diarrhea or vomiting, this medication can cause an oral overdose, as the medication would be expelled before absorption.
• Abnormal potassium levels
• Surgery or other procedures

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Unraveling the side effects lurking behind this medications are as follows:

• Sitagliptin 50mg
• Flu-like symptoms
• Cough
• Diarrhea
• Constipation
• Vomiting
• Tiredness
• Weight loss
• Upper respiratory tract infection (URTI)
• Back pain
• Metformin Hydrochloride 500mgin
• Upper respiratory tract infection (URTI)
• Diarrhea
• Nausea
• Constipation
• Vomiting
• Low blood sugar (hypoglycemia)
• Tingling sensations
• Loss of appetite
• Weight loss
• Gallstones
• Fatigue
• Irritability
• Confusion

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Here are the crucial warnings and precautions for this medication:

• Patients with congestive heart failure (CHF) and those exposed to stress, such as infection, fever, trauma, or surgery, should use this medication with caution.
• It is not intended for the treatment of diabetic ketoacidosis or type 1 diabetes mellitus.
• Renal impairment, particularly with a glomerular filtration rate (GFR) between 30-45 mL/min, requires careful monitoring.
• The safety of this medication during pregnancy has not been well established; it should be used only if recommended by a healthcare provider.

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Drug interactions with metformin and sitagliptin include:

• Insulin and other antidiabetic agents (e.g., sulfonylureas) (may increase risk of hypoglycemia)
• Renal impairment (may require dose adjustments)
• CYP3A4 inhibitors (e.g., ketoconazole) (may increase sitagliptin levels)
• CYP3A4 inducers (e.g., rifampin) (may decrease sitagliptin levels)
• Diuretics (e.g., furosemide) (may increase risk of dehydration and affect blood glucose control)
• NSAIDs (e.g., ibuprofen) (may increase risk of renal impairment)
• Alcohol (may enhance effects on blood glucose levels and increase risk of dehydration)

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When storing Sitagliptin 50mg and metformin hydrochloride 500mg tablets, it is crucial to follow the recommended storage conditions. These tablets should be stored at room temperature, ideally between 15 and 30 degrees Celsius. It's important to note that the tablets must be kept in an airtight container to preserve their efficacy and prevent contamination. This container should be placed in a dry, secure location, away from heat and moisture. Furthermore, ensure that children or pets cannot access the medication to prevent accidental consumption or contamination.Before taking these tablets, it is advised to consult a healthcare professional or pharmacist if you have any questions regarding the storage conditions or medication safety. They will provide you with precise instructions and address any concerns you may have. Following these guidelines will ensure the safe and proper storage of your medication, promoting optimal effectiveness and preserving its quality.

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