TANPADO 75MG TAB 10`S

Tapentadol 75mg Tablet's primary mechanism of action involves dual modes of action, acting as both a μ-opioid receptor agonist and a norepinephrine reuptake inhibitor. As an agonist at the μ-opioid receptors, it binds to these receptors in the central nervous system, reducing the perception of pain signals and increasing pain tolerance. This opioid effect helps to alleviate acute and chronic pain. Additionally, tapentadol inhibits the reuptake of norepinephrine, a neurotransmitter involved in pain modulation. By blocking the reuptake of norepinephrine, it increases its availability in the synaptic cleft, enhancing its analgesic effect. This dual action provides effective pain relief by targeting both the opioid and noradrenergic systems, making it useful for managing various types of pain.

Centrally acting opioid analgesic.

Oral

The following are the uses of Tapentadol 75mg Tablet:

• Used for managing moderate to severe acute pain, providing effective pain relief.
• Used for treating neuropathic pain associated with conditions like diabetic peripheral neuropathy.
• Used to alleviate chronic pain when other treatments are insufficient.
• Used to help individuals regain functionality and improve their quality of life by managing pain.
• Used for short-term pain management post-surgery or due to injuries.
• Used to reduce pain intensity, allowing better pain control and comfort.

In the case of an overdose of Tapentadol 75mg Tablets, individuals may experience severe symptoms such as difficulty breathing, extreme drowsiness, and a significant decrease in heart rate. Overdose can lead to a potentially life-threatening condition called respiratory depression, where breathing becomes dangerously slow or shallow. It is imperative to seek emergency medical assistance promptly if an overdose is suspected, as this can help prevent further complications and ensure appropriate treatment. Recognizing the signs of overdose and acting swiftly can be crucial in managing this situation effectively.

In the case of a missed dose of Tapentadol 75mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one, as this may increase the risk of side effects. It is advisable to set reminders or use a pill organizer to help you remember to take your medication at the correct times each day. If you frequently miss doses, consult your healthcare provider for advice on how to improve your medication adherence.

To take Tapentadol 75mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional, without crushing or chewing the tablet.

Following are the conditions/situations when Tapentadol 75mg Tablet should not be used:

• Should not be used in individuals with a known allergy to Tapentadol or any opioids.
• Contraindicated in patients with severe respiratory depression or asthma, as it can worsen breathing.
• Not recommended for individuals with a recent head injury or increased intracranial pressure.
• Should not be used in patients with severe liver impairment or severe kidney disease.
• Contraindicated during or immediately before labor and delivery due to potential harm to the newborn.
• Not suitable for individuals with a history of seizures or conditions that increase seizure risk.
• Should be avoided in patients with gastrointestinal obstruction or conditions causing prolonged constipation.
• Must not be used in patients currently taking or having recently taken MAO inhibitors.
• Should not be combined with sedatives, tranquilizers, or other opioids due to increased risk of respiratory depression.

The side effects of Tapentadol 75mg Tablet may include:

• Nausea and vomiting
• Dizziness or lightheadedness
• Sleepiness or drowsiness
• Constipation
• Dry mouth
• Itching or sweating
• Headache
• Blurred vision

Following are the precautions and warnings for Tapentadol 75mg Tablet:

• This medication is a potent opioid and should be used with extreme caution in patients with a history of substance abuse or addiction, as it can lead to dependence and withdrawal symptoms.
• Tapentadol can cause respiratory depression, especially when used in higher doses or in individuals with compromised respiratory function. Close monitoring is required for any signs of breathing difficulties.
• Elderly patients may be more sensitive to the effects of Tapentadol, and dosage adjustments might be necessary to prevent adverse reactions.
• Patients with liver or kidney disease should exercise caution and consult a healthcare professional before taking this medication, as it is metabolized by the liver and excreted by the kidneys.
• Tapentadol may cause seizures in some individuals, particularly those with a history of seizures or conditions that lower the seizure threshold.
• It may impair cognitive and physical abilities, and patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Tapentadol should be used with caution in patients with head injuries or increased intracranial pressure, as it can mask important neurological signs.
• Do not combine with other central nervous system depressants without medical supervision as it may enhance the sedative effects and increase the risk of serious side effects.

Following are the drug interactions for Tapentadol 75mg Tablet:

• Monoamine oxidase inhibitors (MAOIs) should not be taken concurrently, as this can lead to a potentially fatal condition known as serotonin syndrome.
• Serotonin and norepinephrine reuptake inhibitors (SNRIs) and selective serotonin reuptake inhibitors (SSRIs) may increase serotonin levels, heightening the risk of serotonin syndrome.
• Tapentadol can intensify the central nervous system effects of benzodiazepines, sedatives, and alcohol, potentially causing respiratory depression.
• Anticonvulsants like carbamazepine can lower tapentadol levels, reducing its effectiveness.
• CYP3A4 inducers such as rifampicin may decrease tapentadol's effectiveness by increasing its metabolism.
• CYP2D6 inhibitors like fluoxetine can increase tapentadol levels, potentially leading to respiratory depression.
• The risk of respiratory depression and sedation increases when combined with other central nervous system depressants, including opioids and antipsychotics.

Following are the food interactions for Tapentadol 75mg Tablet:

• Grapefruit and grapefruit juice consumption should be avoided as they can influence the metabolism of Tapentadol, potentially leading to increased blood levels and heightened side effects.
• Alcohol is not recommended while taking Tapentadol as it can enhance the sedative effects, increasing the risk of dizziness, drowsiness, and impaired coordination.
• Fatty foods may slightly delay the absorption of Tapentadol, but this effect is generally not clinically significant.
• Caffeinated beverages may reduce the sedative effects of Tapentadol, which could potentially lead to increased pain perception.
• High-fat meals might lead to a slight increase in Tapentadol exposure, but this is unlikely to be clinically relevant.
• Avoid consuming herbal teas or supplements containing St. John's Wort, as it can affect the metabolism of Tapentadol.
• Always follow the advice of your healthcare professional regarding dietary restrictions or recommendations when taking Tapentadol.
• No significant food interactions are known to directly impact the absorption or efficacy of Tapentadol, but maintaining a balanced diet is generally advised.

Tapentadol 75mg Tablets should be stored in a secure and dry location, specifically in a medicine cabinet or similar storage area, ensuring it remains out of reach of children and pets. Maintain a consistent room temperature, avoiding exposure to direct sunlight, excessive heat, or moisture, as these conditions can degrade the medication's quality. Always keep the tablets in their original container, tightly sealed, to prevent contamination and maintain their effectiveness. Regularly check the expiration date, and if the medication is no longer needed or has expired, proper disposal is crucial. Do not discard Tapentadol tablets in household trash or down the drain; instead, consult your pharmacist or healthcare provider for guidance on safe disposal methods to protect the environment and prevent misuse.

Following are the quick tips for Tapentadol 75mg Tablet:

• Consult a doctor for a proper prescription and dosage guidance.
• Take the tablet whole with a sufficient amount of water.
• Adhere to the prescribed dosage and duration for effective pain management.
• Avoid crushing, chewing, or splitting the tablet unless advised by a healthcare professional.
• Do not adjust the dose without medical advice, even if you feel better.
• Inform your doctor about any other medications you are taking to prevent potential interactions.
• Store the medication at room temperature, away from heat and moisture.
• Keep the tablets out of reach of children and pets to prevent accidental consumption.