Tanzo (4.5g/20ml) 1 Vial Injection

Piperacillin and Tazobactam Injection is a combination antibiotic. Piperacillin is a broad-spectrum penicillin-class beta-lactam antibiotic that works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), disrupting the synthesis of peptidoglycan, which is a critical component of the bacterial cell wall. This leads to cell wall weakening, lysis, and ultimately bacterial death. However, many bacteria produce beta-lactamase enzymes that can inactivate piperacillin. To counteract this, Tazobactam, a beta-lactamase inhibitor, is included in the formulation. Tazobactam binds to and inactivates beta-lactamase enzymes, preventing them from breaking down piperacillin and enhancing its antibacterial effectiveness against beta-lactamase-producing organisms.

Piperacillin, Tazobactam

penicillin combination antibiotics

injection

The following are the uses of Piperacillin and Tazobactam Injection:

• Treatment of moderate to severe infections caused by susceptible bacteria, including pneumonia, urinary tract infections, and intra-abdominal infections.
• Management of complicated skin and soft tissue infections.
• Treatment of septicemia and bacteremia caused by susceptible organisms.
• Management of pelvic inflammatory disease (PID) caused by susceptible bacteria.
• Treatment of bone and joint infections (osteomyelitis) caused by susceptible bacteria.
• Management of febrile neutropenia in immunocompromised patients, especially those with cancer.
• Treatment of infections associated with diabetic foot ulcers.

Following are the doses of Piperacillin and Tazobactam Injection:

• The usual dose for adults with moderate to severe infections is 3.375 grams (2 grams of piperacillin and 0.25 grams of tazobactam) administered every 6 hours via intravenous infusion.
• For more serious infections, the dose may be increased to 4.5 grams (3 grams of piperacillin and 0.5 grams of tazobactam) every 6 hours.
• For patients with renal impairment, the dose and frequency may be adjusted based on the degree of renal function.
• For pediatric patients, the dose is based on body weight, typically 100 mg/kg of piperacillin every 6–8 hours, combined with 12.5 mg/kg of tazobactam.

In case of an overdose of Piperacillin and Tazobactam Injection immediate medical attention should be sought. Overdose symptoms may include symptoms of renal impairment (such as changes in urine output), seizures, or electrolyte imbalances. If an overdose is suspected, the healthcare provider may need to adjust the dosage, provide supportive care, or initiate dialysis in severe cases to remove excess drug from the body. It is important not to attempt any treatments or adjustments on your own.

If you miss a dose of Piperacillin and Tazobactam Injection, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not administer two doses at the same time to make up for the missed dose, as this could increase the risk of side effects or overdose. Always follow the dosing instructions provided by your healthcare provider and consult them if you're unsure about what to do after missing a dose.

To use Piperacillin and Tazobactam Injection, follow the instructions provided by your healthcare provider or as indicated on the prescription label. Typically, the medication is administered intravenously, and the healthcare provider will determine the correct infusion rate and duration based on your specific condition and infection type.

Following are the situations when Piperacillin and Tazobactam Injection should not be used:

• Should not be used in individuals with a known allergy to Piperacillin, Tazobactam, or any of the components of the injection.
• Contraindicated in patients who have a history of hypersensitivity reactions to other penicillins or beta-lactam antibiotics.
• Should not be used in patients with a history of severe renal impairment without proper dose adjustments.
• Not recommended for use in patients with a history of blood dyscrasias or severe hematologic reactions to beta-lactam antibiotics.

The side effects of Piperacillin and Tazobactam Injection may include:

• Diarrhea
• Nausea or vomiting
• Rash or itching
• Fever
• Increased liver enzymes (hepatotoxicity)
• Blood disorders such as thrombocytopenia (low platelet count) or leukopenia (low white blood cell count)
• Seizures (especially in patients with renal impairment or overdose)
• Inflammation or irritation at the injection site
• Superinfection (e.g., fungal infections)
• Renal dysfunction or changes in kidney function tests

Following are the precautions and warnings for Piperacillin and Tazobactam Injection:

• Should be used with caution in patients with a known allergy to penicillins, cephalosporins, or other beta-lactam antibiotics.
• Use with caution in patients with a history of renal impairment, as dosage adjustments may be necessary.
• May cause severe gastrointestinal effects, such as Clostridium difficile-associated diarrhea, especially with prolonged use.
• Use with caution in patients with a history of blood disorders, such as thrombocytopenia or leukopenia.
• Monitor liver function during treatment, as liver enzyme elevations or hepatotoxicity may occur.
• Caution should be taken in pregnant or breastfeeding women; consult a healthcare provider before use.
• May interact with other medications, especially those affecting renal function or blood pressure. Always inform your healthcare provider about all other medications being taken.
• Should not be used if there is a history of hypersensitivity or severe allergic reactions (e.g., anaphylaxis) to beta-lactam antibiotics.

Following are the drug interactions for Piperacillin and Tazobactam Injection:

• Caution is advised when used in combination with anticoagulants (such as warfarin), as Piperacillin may increase the risk of bleeding by affecting platelet function.
• May interact with probenecid, which can decrease the elimination of Piperacillin, leading to higher blood levels of the drug.
• Concomitant use with aminoglycosides (such as gentamicin) may increase the risk of nephrotoxicity, so renal function should be closely monitored.
• Caution is advised when used with diuretics or ACE inhibitors, as these medications may affect renal function, which may require dosage adjustments.
• Oral contraceptives

• Methotrexate

• Use with other antibiotics should be monitored to avoid antagonistic effects and ensure effective bacterial eradication.

Following are the food interactions for Piperacillin and Tazobactam Injection:

• No significant food interactions have been identified for Piperacillin and Tazobactam Injection. However, it is generally recommended to administer the medication on an empty stomach or as directed by your healthcare provider for optimal absorption.
• There are no known interactions with common foods such as dairy products, alcohol, or citrus fruits.
• It is advised to maintain adequate hydration while on this medication, especially if you have kidney-related concerns.

Piperacillin and Tazobactam Injection should be stored in a cool, dry place, away from direct light and moisture. It is typically stored at room temperature between 20°C to 25°C (68°F to 77°F). The medication should not be frozen. If the injection is prepared in advance, it should be refrigerated and used within the timeframe specified by the healthcare provider. Any unused or expired medication should be properly disposed of according to local guidelines or your healthcare provider's instructions. Do not dispose of the medication by flushing it down the toilet or pouring it into a drain. Proper disposal helps prevent accidental exposure and contamination of the environment. Always check with your pharmacist if you're unsure how to safely dispose of unused medication.

Following are the quick tips for Piperacillin and Tazobactam Injection:

• Use Piperacillin and Tazobactam Injection exactly as prescribed by your healthcare provider for optimal effectiveness.
• Ensure proper hydration before and during treatment, especially if you have renal concerns.
• Inform your healthcare provider about any allergies or previous reactions to beta-lactam antibiotics.
• Monitor for signs of gastrointestinal side effects like diarrhea or allergic reactions, and report any unusual symptoms to your healthcare provider.
• Keep track of your treatment schedule and do not skip doses to ensure the infection is fully treated.
• If you're unsure about how to administer the injection, ask your healthcare provider for guidance.

Piperacillin and Tazobactam Injection may require certain laboratory screening and monitoring during treatment, especially for patients with underlying health conditions. The following laboratory tests and monitoring may be considered:

• Renal function tests (e.g., serum creatinine, blood urea nitrogen) to monitor for potential kidney impairment, especially in patients with pre-existing renal issues.
• Liver function tests (e.g., liver enzymes) to check for any hepatic toxicity, particularly if the patient is receiving prolonged treatment.
• Complete blood count (CBC) to monitor for blood-related side effects such as thrombocytopenia or leukopenia.
• Electrolyte levels, especially in patients at risk for imbalances, to ensure proper electrolyte balance is maintained.
• Monitoring for Clostridium difficile infection in patients with prolonged use or those showing gastrointestinal symptoms.