TARCEVA 150MG TAB

Erlotinib 150MG Tablet, a potent inhibitor of tyrosine kinase receptors, primarily targets the epidermal growth factor receptor (EGFR) pathway. Its mechanism of action involves binding to the intracellular tyrosine kinase domain of EGFR, thereby blocking the receptor's autophosphorylation. This inhibition disrupts downstream signaling pathways, such as the RAS/RAF/MAPK cascade and the PI3K/AKT pathway, which play crucial roles in cell proliferation, survival, and angiogenesis. By preventing the activation of these pathways, erlotinib effectively suppresses tumor growth and promotes apoptosis in cancer cells that overexpress EGFR, making it a valuable therapeutic agent in the treatment of certain types of cancers, particularly non-small cell lung cancer with EGFR mutations.

Erlotinib 150MG

Tyrosine kinase inhibitor.

Tablet

The following are the uses of Erlotinib 150MG Tablet:

• Used for treating non-small cell lung cancer that has spread to other parts of the body.
• Used for blocking the growth and spread of cancer cells.
• Used as a targeted therapy for tumors with specific genetic mutations.
• Used to improve survival rates and manage symptoms in advanced lung cancer patients.
• Used in combination with chemotherapy or other targeted therapies.
• Used for managing side effects like skin rash, diarrhea, and fatigue.
• Used as part of a comprehensive cancer treatment plan.

In the case of an overdose of Erlotinib 150MG Tablets, immediate medical attention is necessary. Symptoms of an overdose may include severe skin reactions, such as a rash or peeling skin, as well as gastrointestinal issues like nausea, vomiting, and diarrhea. It is important to seek medical help promptly, as delayed treatment can lead to complications. Ingesting excessive amounts of this medication can result in a range of adverse effects, and healthcare professionals should be involved to provide appropriate care and support.

In the case of a missed dose of Erlotinib 150MG Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to safely adjust your medication regimen and ensure the best treatment outcome. It is advisable to set reminders or keep a medication schedule to minimize the chances of missing doses in the future.

To take Erlotinib 150MG Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, as directed by your healthcare professional, and follow the prescribed dosage and treatment duration without altering or discontinuing the medication.

Here are the conditions or situations when Erlotinib 150MG Tablet should not be used:

• Should not be taken if you have a known allergy to Erlotinib or similar medications.
• Contraindicated in individuals with interstitial lung disease or a history of severe lung problems.
• Not recommended for individuals with severe liver disease or impaired liver function.
• Avoid if you have a history of gastrointestinal perforation or are at risk of developing it.
• Do not use if you have a low white blood cell count (neutropenia) or low platelet count (thrombocytopenia).
• Not suitable for women who are pregnant or breastfeeding.
• Avoid in individuals with a history of eye problems, particularly corneal ulcerations.
• Should not be taken by patients with a history of severe skin reactions or severe acne-like rashes.

The side effects of Erlotinib 150MG Tablet may include:

• Skin rash
• Diarrhea
• Fatigue and weakness
• Loss of appetite
• Nausea and vomiting
• Dry skin or acne
• Respiratory issues, such as coughing or difficulty breathing
• Eye irritation or inflammation

Following are the precautions and warnings for Erlotinib 150MG Tablet:

• This medication is not recommended for individuals with a known allergy to Erlotinib or any of its excipients.
• Patients with liver or kidney disease should use this medication with caution, as dose adjustments might be necessary.
• Erlotinib may cause interstitial lung disease; patients should be monitored for respiratory symptoms.
• It can lead to gastrointestinal perforation; patients should be advised to report severe abdominal pain.
• Avoid use in pregnant women as it may cause fetal harm; effective contraception is recommended during treatment.
• Breastfeeding should be discontinued while on Erlotinib therapy due to potential risks to the infant.
• Patients should be advised to avoid grapefruit and grapefruit juice as they may affect the drug's metabolism.
• Erlotinib may cause severe skin reactions; patients should seek medical attention if they develop a rash or skin issues.

Following are the drug interactions for Erlotinib 150MG Tablet:

• Erlotinib can significantly reduce the metabolism of medications like paracetamol, potentially leading to increased blood levels and enhanced side effects.
• The effectiveness of warfarin and other anticoagulants may be altered, requiring careful monitoring of coagulation parameters.
• Combining with certain antibiotics, such as erythromycin or clarithromycin, can lead to increased erlotinib concentrations in the body.
• Erlotinib may interact with anti-seizure medications like phenytoin or carbamazepine, affecting their blood levels and potentially requiring dosage adjustments.
• The use of proton pump inhibitors (PPIs) like omeprazole may reduce erlotinib absorption, potentially impacting its effectiveness.
• It can increase the risk of bleeding when taken with antiplatelet drugs such as clopidogrel.
• Caution is advised when using with other medications that inhibit CYP3A4 enzyme activity, as this may lead to elevated erlotinib levels.

Following are the food interactions for Erlotinib 150MG Tablet:

• Grapefruit and grapefruit juice should be avoided as they can alter the metabolism of Erlotinib, potentially leading to increased drug levels in the blood and a higher risk of side effects.
• Avoid high-fat meals as they can increase the absorption of Erlotinib, resulting in higher blood concentrations and potential toxicity.
• Alcohol consumption may increase the risk of liver toxicity when taking Erlotinib, and it's advisable to limit or avoid alcohol during treatment.
• Avoid smoking as it can interfere with the effectiveness of Erlotinib and potentially reduce its therapeutic benefits.
• Certain foods rich in vitamin K, like leafy green vegetables, should be consumed consistently as Erlotinib may affect blood clotting.
• Maintain a balanced diet with adequate hydration to support overall health during treatment.
• Inform your healthcare provider about any dietary supplements or herbal products you use to ensure they don't interfere with Erlotinib's effectiveness.

Erlotinib 150MG Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area, at room temperature (around 20-25°C or 68-77°F). It is crucial to keep the tablets in their original container, tightly sealed, to maintain their integrity and protect them from moisture and light. Avoid storing them in the bathroom or kitchen, as these areas may have high humidity or temperature fluctuations. Always check the expiration date on the packaging, and do not use the medication if it is past its expiry. For disposal, do not throw the tablets into the trash or flush them down the toilet. Instead, follow local guidelines for medication disposal or consult your pharmacist for environmentally friendly disposal options to ensure that the medication is safely discarded without harming the environment. Keep the tablets out of the sight and reach of children and pets to prevent accidental consumption.

Following are the quick tips for Erlotinib 150MG Tablet:

• Take the tablet on an empty stomach, at least 1 hour before or 2 hours after a meal.
• Swallow the tablet whole with a full glass of water; do not crush, chew, or break it.
• Maintain a consistent medication schedule by taking it at the same time each day.
• Avoid grapefruit and grapefruit juice during treatment as they can affect drug metabolism.
• Inform your doctor about all medications you are taking to prevent potential drug interactions.
• Regularly monitor your liver function and blood cell counts as advised by your healthcare provider.
• Store the medication at room temperature, away from moisture and light.