Targocid (400mg) 1 Injection

Teicoplanin 400mg Injection, a glycopeptide antibiotic, primarily targets bacterial cell wall synthesis. It specifically binds to the terminal D-alanyl-D-alanine residues of the peptidoglycan precursors, preventing their incorporation into the growing peptidoglycan chain. This binding interferes with the cross-linking of peptidoglycan layers, leading to weakened cell walls and eventual cell lysis. Teicoplanin's mechanism of action is similar to that of vancomycin, inhibiting the transglycosylation and transpeptidation steps in the synthesis of bacterial cell walls. This action is particularly effective against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and other resistant strains.

Glycopeptide antibiotic.

Injection

The following are the uses of Teicoplanin 400mg Injection:

• Used for treating serious bacterial infections, particularly in patients with bone and joint infections.
• Used for its effectiveness against a range of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA).
• Used for skin and soft tissue infections, providing a targeted approach to combat bacterial growth.
• Used as an alternative for patients allergic to penicillin, offering a crucial treatment option.
• Used in severe cases of endocarditis, a heart infection, to prevent complications.
• Used to prevent infections during high-risk surgeries, ensuring patient safety.
• Used for its ability to penetrate tissues and maintain therapeutic levels, ensuring consistent treatment.

In the case of an overdose of Teicoplanin 400mg Injection, it is important to recognize the potential symptoms and seek medical assistance promptly. Overdose symptoms may include gastrointestinal issues, hearing impairment, and kidney problems. If an overdose is suspected, immediate steps should be taken to contact a healthcare professional or poison control center for guidance on the appropriate treatment and management of the overdose. Timely intervention is crucial to ensure the best possible outcome.

In the case of a missed dose of Teicoplanin 400mg Injection, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare professional for advice on how to safely adjust your medication schedule and ensure the best possible treatment outcome.

To administer Teicoplanin 400mg Injection, prepare the medication by drawing the prescribed dose into a syringe, then locate a suitable injection site, clean the area, and carefully inject the medication subcutaneously or intramuscularly, following the instructions provided by your healthcare professional.

Here are the conditions or situations when Teicoplanin 400mg Injection should not be used:

• Avoid using if you have a known allergy to Teicoplanin or other glycopeptide antibiotics such as vancomycin.
• Not recommended for individuals with severe kidney disease or those on dialysis.
• Contraindicated in patients with a history of pseudomembranous colitis or antibiotic-associated colitis.
• Should not be used in patients with known or suspected hypersensitivity to any of its excipients.
• Not suitable for the treatment of viral infections such as flu or common cold.
• Do not use if you have a history of severe allergic reactions to other antibiotics.
• Avoid using if you have or have ever had Myasthenia Gravis.

The side effects of Teicoplanin 400mg Injection may include:

• Skin rash or itching
• Nausea and vomiting
• Diarrhea
• Fever
• Injection site reactions (pain, redness, swelling)
• Headache
• Hearing loss (ototoxicity)
• Kidney problems (nephrotoxicity)
• Blood disorders (e.g., thrombocytopenia, leukopenia)

Following are the precautions and warnings for Teicoplanin 400mg Injection:

• Avoid use in patients with known hypersensitivity to teicoplanin or glycopeptide antibiotics.
• Use with caution in patients with renal impairment, as dose adjustments may be necessary to prevent toxicity.
• May cause severe hypersensitivity reactions, including anaphylaxis; discontinue use if signs of an allergic reaction occur.
• Monitor kidney and liver function regularly during prolonged use to detect potential toxicity.
• May cause ototoxicity (hearing loss or tinnitus), especially in patients receiving high doses or those with pre-existing hearing problems.
• Use with caution in elderly patients, as they may be more susceptible to side effects.
• May cause blood disorders such as thrombocytopenia, neutropenia, or eosinophilia; regular blood monitoring may be required.
• Can lead to "Red Man Syndrome" (flushing, rash, or hypotension) if infused too rapidly; administer slowly to reduce risk.
• Concurrent use with other nephrotoxic or ototoxic drugs (e.g., aminoglycosides, loop diuretics) may increase the risk of toxicity.
• Pregnant or breastfeeding women should consult a healthcare provider before use.

Following are the drug interactions for Teicoplanin 400mg Injection:

• Concomitant use with other antibiotics like vancomycin or gentamicin may increase the risk of hearing loss and kidney damage.
• Teicoplanin can interact with muscle relaxants, such as vecuronium, enhancing their effects and prolonging neuromuscular blockade.
• The effects of anticoagulants like warfarin may be altered, requiring close monitoring of blood clotting parameters.
• Caution is advised when using with diuretics, as it may increase the risk of hearing and kidney toxicity.
• Interactions with live vaccines may decrease their effectiveness. Consider postponing vaccination until after treatment.
• Teicoplanin may reduce the effectiveness of oral contraceptives, requiring additional contraceptive measures.
• It may increase the blood levels of cyclosporine, potentially leading to toxicity.

Following are the food interactions to be aware of when using Teicoplanin 400mg Injection:

• Avoid consuming grapefruit or grapefruit juice as they may influence the levels of the medication in the bloodstream, potentially affecting its efficacy.
• Alcohol consumption should be minimized or avoided as it can enhance the sedative effects and increase the risk of adverse reactions.
• Teicoplanin may cause stomach upset, so it is advisable to take the medication with food to reduce gastrointestinal discomfort.
• Dairy products and calcium-rich foods should be avoided around the time of medication intake as they can interfere with the absorption of Teicoplanin.
• Maintain a balanced diet to ensure the medication's effectiveness and overall well-being during the treatment period.
• Avoid high-fat meals as they may delay the absorption of Teicoplanin, potentially affecting its therapeutic effect.
• Stay well-hydrated to support overall health and kidney function while using this medication.
• Consult your healthcare provider for specific dietary recommendations tailored to your medical condition and treatment plan.

Teicoplanin 400mg Injection should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. It is crucial to keep the injection in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. Avoid exposing it to extreme temperatures, such as storing it in the refrigerator or leaving it in a hot car, as this can impact its effectiveness. Always check the expiration date before use, and responsibly dispose of any unused or expired injections. Proper disposal methods may include returning the medication to a pharmacy or healthcare facility for safe disposal, ensuring it does not end up in landfills or water sources. Keep the medication out of children's reach to prevent accidental ingestion.

Following are the quick tips for Teicoplanin 400mg Injection:

• Administer the injection under medical supervision for optimal therapeutic effect.
• Ensure proper dosage and duration as prescribed by your doctor.
• It is typically given as a slow intravenous injection over 3-5 minutes.
• Do not mix or dilute the injection unless instructed by a healthcare professional.
• Inform your doctor if you have existing kidney or liver conditions before use.
• Store the injection as directed by your pharmacist, usually at room temperature.
• Seek immediate medical attention if you experience signs of an allergic reaction.