TARONTAL IMP 400MG TAB 20'S (PENTOXIFYLINE)

Pentoxifylline 400MG Tablet primarily exerts its therapeutic effects through several mechanisms of action. It acts as a phosphodiesterase inhibitor, primarily targeting phosphodiesterase type 4 (PDE4), which leads to increased intracellular levels of cyclic adenosine monophosphate (cAMP). This elevation in cAMP relaxes smooth muscle cells, particularly in the vascular system, resulting in improved blood flow and reduced blood viscosity. Pentoxifylline also possesses anti-inflammatory properties by inhibiting the production of pro-inflammatory cytokines and reducing the expression of adhesion molecules on endothelial cells, thereby decreasing the adhesion of leukocytes to blood vessel walls. This dual action helps in enhancing microcirculation and promoting better tissue oxygenation.

Vasodilator, Anti-inflammatory

Tablet

The following are the uses of Pentoxifylline 400MG Tablet:

• Used for treating blood circulation issues, especially in conditions like peripheral vascular disease, where improved blood flow is needed in the legs and feet.
• Used for reducing pain, cramping, and walking distance in patients with intermittent claudication, allowing for better mobility.
• Used for managing skin conditions such as ulcers, eczema, and psoriasis by improving blood flow to the affected areas.
• Used for treating memory and concentration issues in patients with vascular dementia.
• Used for addressing erectile dysfunction by enhancing blood flow to the penis.
• Used for relieving symptoms of tinnitus, possibly by improving blood circulation in the inner ear.
• Used for managing certain types of headaches, particularly those related to poor blood circulation.
• Used for supporting overall cardiovascular health and promoting healthy blood flow in various conditions as prescribed by a healthcare professional.

In the case of an overdose of Pentoxifylline 400MG Tablets, symptoms may include severe gastrointestinal distress, such as nausea, vomiting, and diarrhea. Additionally, there could be cardiovascular effects like a rapid or irregular heartbeat, and central nervous system symptoms like dizziness, headache, and confusion. It is imperative to seek medical advice promptly, as timely intervention can mitigate the severity of these symptoms and prevent potential long-term complications.

In the case of a missed dose of Pentoxifylline 400MG Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to adjust your dosing schedule and ensure the medication's effectiveness. It is important to maintain a consistent medication routine for optimal results.

To take Pentoxifylline 400MG Tablet, swallow the tablet whole with a full glass of water, usually three times a day or as directed by your healthcare professional, ensuring you follow the prescribed dosage and duration of treatment.

Here are the conditions or situations when Pentoxifylline 400MG Tablet should not be taken:

• Avoid if you have a known allergy to Pentoxifylline or other xanthine derivatives.
• Do not use if you have a history of recent cerebral hemorrhage or severe bleeding disorders.
• Contraindicated in individuals with severe heart failure or an acute myocardial infarction (heart attack).
• Should not be used in patients with recent retinal or pre-retinal hemorrhage.
• Not recommended for individuals with a history of severe liver impairment.
• Avoid if you have a history of acute cerebrovascular disease.
• Do not administer to patients with a history of peptic ulcer disease.

The side effects of Pentoxifylline 400MG Tablet may include:

• Nausea and vomiting.
• Stomach pain or cramps.
• Diarrhea.
• Dizziness or lightheadedness.
• Headache.
• Skin rash or itching.
• Increased heart rate or palpitations.
• Bleeding tendency, such as nosebleeds or easy bruising.

Following are the precautions and warnings for Pentoxifylline 400MG Tablet:

• Avoid use if you have a known allergy to Pentoxifylline or related medications.
• Patients with a history of bleeding disorders or gastrointestinal bleeding should exercise caution, as the medication may increase the risk of bleeding.
• Individuals with cardiovascular disease, hypertension, or hypotension should be monitored closely as blood pressure changes may occur.
• Caution is advised in patients with kidney or liver impairment, as dosage adjustments might be necessary.
• Do not abruptly discontinue the medication; gradually reduce the dosage to minimize withdrawal symptoms.
• Elderly patients may be more susceptible to side effects, so regular monitoring is essential.
• Consult a doctor if you are pregnant, planning to become pregnant, or breastfeeding, as the medication may have potential risks.

Following are the drug interactions for Pentoxifylline 400MG Tablet:

• Pentoxifylline may increase the effects of anticoagulants like warfarin, heparin, or clopidogrel, leading to a higher risk of bleeding.
• It can interact with antihypertensive drugs, such as beta-blockers or ACE inhibitors, causing an excessive drop in blood pressure.
• The effect of insulin and oral hypoglycemic agents may be enhanced, resulting in low blood sugar levels.
• Caution is advised when combined with other drugs that increase bleeding risk, like nonsteroidal anti-inflammatory drugs (NSAIDs).
• Pentoxifylline may increase the concentration of certain antibiotics, e.g., ciprofloxacin or erythromycin, potentially increasing side effects.
• It can interact with drugs metabolized by the liver, such as phenytoin or carbamazepine, altering their effectiveness.
• Alcohol consumption may intensify the side effects of Pentoxifylline, including dizziness and gastrointestinal issues.

Following are the food interactions for Pentoxifylline 400MG Tablet:

• Grapefruit and grapefruit juice consumption should be avoided as they can increase the levels of the drug in the body, leading to potential side effects.
• Alcohol should be used with caution as it may enhance the risk of bleeding, especially when combined with Pentoxifylline's blood-thinning properties.
• High-fat meals can delay the absorption of Pentoxifylline, leading to reduced effectiveness.
• Caffeine intake should be monitored as it may increase the risk of side effects such as nervousness and tremors.
• Foods rich in vitamin E and omega-3 fatty acids may interact, increasing the risk of bleeding.
• Avoid consuming herbal supplements like Ginkgo Biloba, as they can intensify the blood-thinning effects.
• Spicy foods might irritate the stomach, especially for those with gastrointestinal sensitivity.
• Always take the medication with a full glass of water to aid in proper absorption.

Pentoxifylline 400MG Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. It is crucial not to expose the medication to excessive heat or cold, so avoid storing it in the bathroom or near appliances that generate heat. Always adhere to the expiration date indicated on the packaging, and when disposing of unused or expired tablets, do not flush them or pour them down the drain. Consult your pharmacist or local waste management guidelines for safe disposal practices. Additionally, ensure that the medication is stored out of children's reach to prevent accidental consumption.

Following are the quick tips for Pentoxifylline 400MG Tablet:

• Consult your doctor for the right dosage and duration based on your medical condition.
• Take the tablet with or after meals to prevent stomach upset.
• Swallow the tablet whole without crushing or chewing for optimal absorption.
• Maintain a consistent schedule for taking the medication as directed.
• Do not double the dose to make up for a missed one; take it as soon as you remember.
• Inform your doctor about all your current medications to avoid potential interactions.
• Store the medication in a cool, dry place away from direct sunlight and moisture.
• Keep the medicine out of children's reach to prevent accidental consumption.