Tavanic (500mg/100ml) 1 Vial Infusion

Levofloxacin, the active ingredient in Levofloxacin 500mg Infusion, primarily exerts its antibacterial effect by inhibiting bacterial DNA gyrase, a type II topoisomerase enzyme essential for bacterial DNA replication, transcription, and repair. This inhibition leads to the stabilization of the DNA-gyrase complex, causing double-stranded DNA breaks and preventing DNA supercoiling, which is crucial for bacterial cell survival. As a result, levofloxacin disrupts the DNA synthesis process, leading to bacterial cell death, particularly in susceptible bacteria. The mechanism of action is specific to bacterial topoisomerases, making it effective against a broad spectrum of Gram-positive and Gram-negative bacteria, while minimizing adverse effects on human cells.

Levofloxacin 500mg

Fluoroquinolone antibiotic

Infusion

The following are the uses of Levofloxacin 500mg Infusion:

• Used for treating severe bacterial infections that require intravenous antibiotics, such as pneumonia, skin and soft tissue infections, and complicated urinary tract infections.
• Used for its effectiveness against a broad range of bacteria, including Gram-positive and Gram-negative organisms.
• Used for patients who cannot take oral medications or when rapid onset of action is required.
• Used in cases where the infection is severe, rapidly progressing, or life-threatening.
• Used as an alternative for patients with resistant bacterial infections or those allergic to other antibiotics.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• For adults with community-acquired pneumonia, the recommended dose is 500 mg once daily for 5 to 7 days.
• For adults with chronic bacterial prostatitis, the recommended dose is 750 mg once daily for 7 days.
• For adults with acute exacerbation of chronic bronchitis, the recommended dose is 500 mg once daily for 5 days.

In the case of an overdose of Levofloxacin 500mg Infusion, it is important to recognize the potential risks and act promptly. Symptoms may include gastrointestinal issues, increased sensitivity to light, and altered mental state. Seek medical advice immediately, as prompt intervention can help manage adverse effects. Emergency care may involve monitoring vital signs, administering fluids, and providing supportive care to mitigate the impact of the overdose. Timely action is essential for a positive outcome.

In the case of a missed dose of Levofloxacin 500mg Infusion, it is important to administer the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance, as they may advise you to restart the medication or provide specific instructions to ensure the treatment's effectiveness.

To administer Levofloxacin 500mg Infusion, dissolve the contents of the vial in 100-200 mL of a compatible diluent, such as 0.9% sodium chloride or 5% dextrose solution, and infuse the mixture intravenously over a period of 60-90 minutes, ensuring slow and controlled administration.

Following are the conditions/situations when Levofloxacin 500mg Infusion should not be used:

• Should not be used in patients with a known allergy or hypersensitivity to Levofloxacin or other quinolone antibiotics.
• Contraindicated in individuals with a history of tendinitis or tendon rupture associated with quinolone use.
• Not recommended for patients with epilepsy or other seizure disorders, as it may lower the seizure threshold.
• Should be avoided in patients with a history of myasthenia gravis, as it can exacerbate muscle weakness.
• Contraindicated in individuals with prolonged QT interval or known heart rhythm disorders.
• Not suitable for patients with severe liver disease or impaired liver function.
• Should not be used in children and adolescents under 18 years of age, as it can affect bone and joint development.
• Contraindicated in pregnant and breastfeeding women due to potential risks to the fetus and infant.
• Should be discontinued if severe diarrhea, abdominal pain, or signs of tendonitis occur during treatment.
• Avoid exposure to direct sunlight or UV rays, as it may increase sensitivity to light.

The side effects of Levofloxacin 500mg Infusion may include:

• Nausea and vomiting
• Diarrhea
• Headache
• Dizziness
• Insomnia
• Skin rash or itching
• Joint or muscle pain
• Increased sensitivity to sunlight

Following are the precautions and warnings for Levofloxacin 500mg Infusion:

• Do not use if you are allergic to Levofloxacin or any similar antibiotics from the fluoroquinolone class.
• This medication may cause serious nerve damage, leading to pain, burning, tingling, numbness, or weakness in the hands or feet. Contact your doctor immediately if you experience any of these symptoms.
• Levofloxacin can increase the risk of tendonitis or tendon rupture, especially in elderly patients. Any signs of tendon inflammation or rupture should be reported to a healthcare professional.
• Patients with a history of kidney disease may require a lower dose adjustment. Regular monitoring of kidney function is advised.
• Avoid excessive exposure to sunlight or UV rays as Levofloxloxacin may make your skin more sensitive to sunlight.
• Do not drive or operate heavy machinery if you experience dizziness, blurred vision, or other side effects that affect your ability to concentrate.
• Inform your doctor if you have a history of heart problems, as Levofloxacin may affect your heart rhythm.
• Pregnant and breastfeeding women should consult their doctor before using this medication, as it may cause harm to the fetus or infant.

Following are the drug interactions for Levofloxacin 500mg Infusion:

• Non-steroidal anti-inflammatory drugs (NSAIDs) may increase the risk of central nervous system stimulation and seizures.
• Theophylline levels can be increased, potentially leading to toxicity.
• Antacids containing multivalent cations (e.g., aluminum, magnesium, calcium, iron) can reduce the absorption of Levofloxacin, leading to reduced effectiveness.
• Probenecid can inhibit the renal tubular secretion of Levofloxacin, resulting in increased plasma concentrations.
• Levofloxacin may enhance the effects of warfarin and other anticoagulants, requiring close monitoring of coagulation parameters.
• When combined with corticosteroids, the risk of tendon disorders may be increased.
• The effectiveness of live attenuated vaccines (e.g., oral polio, measles, mumps, rubella) may be reduced due to Levofloxacin's antibacterial activity.

Following are the food interactions for Levofloxacin 500mg Infusion:

• Avoid consuming dairy products like milk, yogurt, or cheese within 2 hours before or after taking the medication. Calcium can interfere with the absorption of Levofloxacin.
• Avoid caffeine-containing beverages like coffee, tea, or energy drinks. Caffeine may enhance the side effects of Levofloxacin, especially nervousness and insomnia.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of Levofloxacin, potentially increasing its levels in the blood.
• Alcohol should be avoided as it may increase the risk of liver-related side effects and central nervous system side effects such as dizziness and lightheadedness.
• Maintain a balanced diet and ensure adequate hydration during the course of treatment.
• Avoid high-fat meals as they may delay the absorption of Levofloxacin, potentially reducing its effectiveness.
• Avoid natural licorice as it may increase the risk of side effects due to its potential interaction with Levofloxacin.

Levofloxacin 500mg Infusion should be stored in a controlled environment, preferably in a cool and dry place, maintaining a temperature between 68°F and 77°F (20°C and 25°C). Protect the infusion from direct sunlight, excessive heat, and moisture to ensure its stability. Always keep the medication in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. When disposing of Levofloxacin Infusion, do not discard it via household waste or sewage systems. Instead, follow local regulations and guidelines for pharmaceutical waste disposal, or consult healthcare professionals or pharmacists for appropriate methods. It is crucial to keep this medication out of the reach of children and pets to prevent accidental consumption, which could be harmful.

Following are the quick tips for Levofloxacin 500mg Infusion:

• Administer the infusion under medical supervision and as directed by your healthcare provider.
• Ensure the infusion is prepared and administered by trained medical personnel.
• Infuse the medication at a controlled rate as prescribed, usually over 60-90 minutes.
• Stay well-hydrated during the infusion to facilitate medication distribution.
• Report any signs of allergic reactions, such as rash, itching, or difficulty breathing, immediately.
• Avoid rapid or bolus injections to prevent potential side effects.
• Store the infusion solution as directed, usually at room temperature, and protect it from light.

Levofloxacin is an antibiotic used to treat bacterial infections, however, it may cause side effects in some individuals. It is crucial to monitor your health while taking this medication to ensure its effectiveness and safety. Your doctor may recommend specific lab tests before and during treatment with Levofloxacin to monitor for these side effects. These tests include a Complete Blood Count to monitor any decrease in white blood cell counts, which can cause bone marrow suppression or neutropenia. Liver Function Tests may be performed to monitor liver enzyme levels to ensure the drug is not causing undue stress on the liver. Prolonged use of Levofloxacin can lead to mild impairment of kidney function, thus Kidney Function Tests may be recommended to measure blood levels of sodium, potassium, creatinine, and BUN. Additional tests may be required based on individual health conditions and other factors. It is important to discuss with your doctor the relevance of these tests to your treatment, and the importance of adhering to the recommended dosage and duration of treatment to minimize risks and achieve the best outcome.