Telmis-A (40/5mg) 14 Tablets

Telmisartan and Amlodipine work synergistically in the Telmisartan 40mg, Amlodipine 5mg Tablet to control blood pressure. Telmisartan blocks the action of angiotensin II, a potent vasoconstrictor, by preventing its binding to the AT1 receptor, which leads to vasodilation and reduced blood pressure. On the other hand, Amlodipine, a calcium channel blocker, inhibits the movement of calcium ions into vascular smooth muscle cells, resulting in relaxation of the arterial smooth muscle and dilation of peripheral arteries, thereby lowering blood pressure. Together, these mechanisms effectively reduce peripheral resistance and improve blood flow, contributing to the management of hypertension.

Angiotensin II receptor blocker, calcium channel blocker.

Tablet

The following are the uses of Telmisartan 40mg, Amlodipine 5mg Tablet:

• Used for managing high blood pressure (hypertension) by relaxing and widening blood vessels, improving blood flow.
• Used for treating hypertension-related complications such as stroke or heart attack prevention.
• Used for reducing the risk of cardiovascular events in patients with high blood pressure and other cardiovascular risk factors.
• Used for improving kidney function in patients with hypertension and diabetic nephropathy.
• Used for alleviating chest pain (angina) by improving blood flow to the heart.
• Used for managing certain types of heart failure by reducing the workload on the heart.
• Used for preventing and treating peripheral edema (swelling in the legs and feet) caused by fluid retention.
• Used for long-term management of hypertension and associated cardiovascular risks.

To be taken as per doctor's prescription

In the case of an overdose of Telmisartan 40mg and Amlodipine 5mg tablets, individuals may experience symptoms such as dizziness, lightheadedness, and a rapid or slow heartbeat. Other possible effects include low blood pressure, excessive urination, and swelling in the hands or feet. Prompt medical intervention is necessary, and individuals should seek emergency care immediately. Treatment may involve monitoring vital signs, providing supportive care, and managing symptoms until the effects of the overdose subside.

In the case of a missed dose of Telmisartan 40mg, Amlodipine 5mg Tablet, take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss several doses, consult your healthcare provider for advice on how to safely resume your medication and maintain the desired therapeutic effect. It's important to take your medication as prescribed to ensure its effectiveness.

To take the Telmisartan 40mg and Amlodipine 5mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare provider.

Here are the conditions or situations when Telmisartan 40mg, Amlodipine 5mg Tablet should not be taken:

• Should not be used in individuals with a known allergy to Telmisartan, Amlodipine, or any of the tablet's components.
• Contraindicated in patients with a history of angioedema (swelling under the skin) related to previous use of ACE inhibitors or Amlodipine.
• Not recommended for individuals with severe liver disease or biliary obstruction.
• Should not be used in patients with severe hypotension (very low blood pressure).
• Contraindicated during pregnancy or breastfeeding.
• Not suitable for individuals with narrow-angle glaucoma.
• Should be avoided in patients with severe aortic stenosis (narrowing of the aortic valve in the heart).
• Not recommended for patients with obstructive jaundice (a type of liver disorder).

The side effects of Telmisartan 40mg, Amlodipine 5mg Tablet may include:

• Dizziness or lightheadedness
• Fatigue or weakness
• Swelling of the ankles and feet (peripheral edema)
• Headache
• Nausea or upset stomach
• Muscle cramps
• Skin rashes or itching
• Increased sensitivity to sunlight

Following are the precautions and warnings for Telmisartan 40mg, Amlodipine 5mg Tablet:

• This medication is not recommended for individuals with a known allergy to Telmisartan, Amlodipine, or any other angiotensin II receptor blockers or calcium channel blockers.
• Patients with a history of liver or kidney disease should exercise caution, as these conditions may affect the metabolism and elimination of the drugs.
• Telmisartan can cause dizziness and lightheadedness, especially when standing up suddenly from a sitting or lying position. Elderly patients should be cautious to avoid falls.
• Amlodipine may lead to swelling in the gums, and proper dental hygiene is essential during treatment. Regular dental check-ups are recommended.
• Patients with severe heart failure should be closely monitored, as Amlodipine may worsen this condition in rare cases.
• Pregnant or breastfeeding women should consult their doctor before taking this medication, as it may cause harm to the fetus or infant.
• Avoid driving or operating heavy machinery until you know how this medication affects you, as it may cause dizziness or drowsiness.
• Inform your doctor about all the medications you are currently taking to avoid potential drug interactions.

Following are the drug interactions for Telmisartan 40mg, Amlodipine 5mg Tablet:

• Potassium-sparing diuretics (e.g., spironolactone, triamterene) may increase the risk of hyperkalemia when used with Telmisartan.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen may reduce the blood pressure-lowering effect of Amlodipine.
• The use of Telmisartan with angiotensin-converting enzyme (ACE) inhibitors may lead to increased risk of kidney impairment.
• Telmisartan may enhance the blood pressure-lowering effect of other antihypertensive drugs, including beta-blockers and diuretics.
• Grapefruit juice can increase the blood levels of Amlodipine, potentially leading to excessive blood pressure reduction.
• Rifampicin, a strong inducer of liver enzymes, may decrease the effectiveness of Telmisartan.
• Antifungal medications such as ketoconazole or itraconazole can increase the plasma concentrations of Amlodipine.

Following are the food interactions for Telmisartan 40mg, Amlodipine 5mg Tablet:

• Grapefruit and grapefruit juice should be avoided as they can increase the blood levels of Amlodipine, leading to an increased risk of side effects like low blood pressure and dizziness.
• Alcohol consumption should be limited as it may enhance the blood pressure-lowering effect of Telmisartan, causing excessive drops in blood pressure.
• Avoid potassium-rich foods like bananas, oranges, and spinach in excess, as Telmisartan can increase potassium levels in the body, and high potassium levels can be harmful.
• Salt substitutes or potassium-containing salt alternatives should be used with caution, as they can increase potassium levels when combined with Telmisartan.
• Maintain a balanced diet, as Amlodipine may cause mild swelling and weight gain in some individuals.
• Avoid high-fat meals as they can increase the absorption of Telmisartan, potentially leading to increased side effects.
• No significant interactions with dairy products or other specific foods have been reported for this medication combination.

Telmisartan 40mg, Amlodipine 5mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. Keep the tablets in their original packaging, tightly sealed, to maintain their integrity and effectiveness. It is crucial not to expose the medication to excessive heat or cold, as this can impact its potency. Always check the expiration date and do not use the tablets beyond this date. For disposal, do not throw the medication in the trash or flush it down the toilet; instead, consult your pharmacist or local waste management guidelines for safe and environmentally friendly disposal practices, ensuring that the medication does not contaminate water sources or harm the environment. Keep the tablets out of children's reach to prevent accidental consumption.

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Following are the quick tips for Telmisartan 40mg, Amlodipine 5mg Tablet:

• Take the tablet as directed by your doctor, typically once daily.
• Consume the tablet with a glass of water, preferably at the same time each day.
• It can be taken with or without food, but taking it with food can prevent stomach irritation.
• Avoid crushing or chewing the tablet; swallow it whole for effective absorption.
• If you miss a dose, take it as soon as you remember, unless it's close to your next dose.
• Do not double the dose to make up for a missed one.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.