TERMIBEX 156.25MG SYP

Co-Amoxiclav 156.25mg/5ml Syrup/Suspension is a combination antibiotic that exhibits its bactericidal effect through multiple mechanisms. Amoxicillin, a semisynthetic penicillin, inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, which ultimately leads to cell lysis. Clavulanic acid, the second component, is a beta-lactamase inhibitor that protects amoxicillin from degradation by bacterial enzymes, thereby extending its spectrum of activity to include bacteria that produce these enzymes. Together, this combination provides a synergistic effect, enhancing the effectiveness against a wide range of bacteria, including those that are resistant to amoxicillin alone.

Co-Amoxiclav 156.25mg/5ml

Antibiotic, penicillin combination

Suspension

The following are the uses of Co-Amoxiclav 156.25mg/5ml Syrup/Suspension:

• Used for treating severe ear, nose, and throat infections, particularly those affecting the sinuses, tonsils, and middle ear.
• Used for managing lower respiratory tract infections like acute bronchitis and pneumonia.
• Used for controlling skin and soft tissue infections, including severe cellulitis and animal bites.
• Used for addressing severe kidney and urinary tract infections, ensuring effective treatment.
• Used for combating gynecological infections, offering relief and preventing complications.
• Used for managing severe dental infections, providing essential treatment.
• Used for treating patients with low immunity and those at risk of developing severe infections.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Co-Amoxiclav is a combination of two antibiotics Amoxicillin and Clavulanic Acid, and is commonly used to treat bacterial infections.
• Consult a medical professional for any medication alteration.
• For Adults with Acute Tonsillitis- 875/125 mg taken every 8 hours or 375/62.5 mg taken every 8 hours.
• For Adults with Skin and Skin Structure Infections- 875/125 mg taken every 12 hours or 375/62.5 mg taken every 12 hours.
• For Adult community-acquired pneumonia- 875/125 mg taken every 8 hours or 575/75 mg taken every 8 hours.
• For Adults with Gonorrhea- 875/125 mg taken once, then 625/125 mg taken every 12 hours for a total of three doses.
• For Adults with Intra-abdominal Infection- See adult dosage but extend the course to 7-10 days.
• For Children (3 months and older) with Acute Otitis Media- 20-40 mg/kg/day in two divided doses. Give the lowest dose feasible, particularly in young infants below 90 days.
• For Children with Pharyngitis and Tonsillitis- 40-60 mg/kg/day in divided doses every 8 hours, not to exceed 1,500 mg/day.
• For Children with Sinusitis and Bronchitis- 40-60 mg/kg/day in divided doses every 8 hours, not to exceed 1,500 mg/day. For children 1 month and older, a dose of 10-15 mg/kg every 8 hours is recommended, not to exceed 700 mg/day.

In the case of an overdose of Co-Amoxiclav 156.25mg/5ml Syrup/Suspension, symptoms may include nausea, vomiting, diarrhea, and skin rashes. It is important to seek medical advice immediately if you suspect an overdose. Treatment may involve managing these symptoms and ensuring the patient receives adequate hydration. Prompt medical intervention can help alleviate potential adverse effects and ensure the patient's well-being. Always exercise caution when administering medications, especially to children.

In the case of a missed dose of Co-Amoxiclav 156.25mg/5ml Syrup/Suspension, it is important to administer the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to adjust your medication regimen. It is essential to maintain a consistent dosing routine for the medication to be most effective.

To administer Co-Amoxiclav 156.25mg/5ml Syrup/Suspension, shake the bottle well, measure the prescribed dose with an accurate measuring device, and administer it orally, following the dosage instructions provided by your healthcare professional, typically taken every 8 hours for a specified duration.

Here are the conditions or situations when Co-Amoxiclav 156.25mg/5ml Syrup/Suspension should not be taken:

• Not suitable for individuals with a known allergy to amoxicillin, clavulanic acid, or any other penicillin-derived antibiotics.
• Contraindicated in patients with a history of severe allergic reactions to beta-lactam antibiotics.
• Should not be used in individuals with a previous history of liver problems or jaundice associated with amoxicillin/clavulanate use.
• Not recommended for patients with severe kidney disease without adjusting the dose.
• Avoid in patients with infectious mononucleosis or lymphatic leukemia.
• Do not use if you have a history of gastrointestinal diseases, especially colitis or antibiotic-associated colitis.
• Contraindicated in patients with a history of high fever and rash with amoxicillin use.

The side effects of Co-Amoxiclav 156.25mg/5ml Syrup/Suspension may include:

• Diarrhea
• Nausea and vomiting
• Skin rash or itching
• Fatigue or drowsiness
• Headache
• Dizziness
• Yeast infections (candidiasis)
• Allergic reactions (e.g., hives, difficulty breathing)

Following are the precautions and warnings for Co-Amoxiclav 156.25mg/5ml Syrup/Suspension:

• This medication should not be used if you are allergic to any penicillin-type antibiotics or beta-lactamase inhibitors.
• Ensure you complete the full prescribed course, even if you feel better, to prevent the risk of antibiotic resistance.
• Do not use this medication to treat viral infections like the common cold or flu.
• Patients with a history of gastrointestinal problems, especially colitis, should use this medication with caution as it may worsen these conditions.
• Inform your doctor if you have kidney or liver problems, as they may need to adjust the dosage accordingly.
• Co-Amoxiclav may interact with other medications; inform your healthcare provider about all the medicines you are taking.
• In case of severe diarrhea or persistent skin rash, stop using the medication and seek medical advice immediately.
• Store the medication properly and keep it out of the reach of children.

Following are the drug interactions for Co-Amoxiclav 156.25mg/5ml Syrup/Suspension:

• Probenecid can decrease the excretion of amoxicillin, leading to higher blood levels and potential side effects.
• Concurrent use with allopurinol may increase the risk of allergic reactions.
• Co-Amoxiclav may reduce the effectiveness of oral contraceptives, requiring additional contraceptive measures.
• The risk of bleeding may increase when taken with anticoagulants like warfarin.
• When combined with mycophenolate mofetil, it can reduce the latter's effectiveness.
• Methotrexate levels may rise when used together, increasing toxicity.
• May decrease the absorption of thyroid hormones, necessitating dosage adjustments.

Following are the food interactions for Co-Amoxiclav 156.25mg/5ml Syrup/Suspension:

• Avoid consuming grapefruit and grapefruit juice as they can interfere with the medication's metabolism, potentially increasing the levels of amoxicillin in the blood and raising the risk of side effects.
• Alcohol intake should be minimized or avoided during the course of this medication to prevent potential liver damage and reduce the risk of stomach irritation.
• Dairy products like milk, yogurt, and cheese can hinder the absorption of amoxicillin. It's best to separate them by at least 2 hours before or after taking the medication.
• High-fat meals can delay the absorption of amoxicillin, potentially reducing its effectiveness. It's advisable to take the medication on an empty stomach or with a light meal.
• Avoid consuming iron-rich foods or supplements within 2 hours of taking Co-Amoxiclav as iron can decrease the absorption of amoxicillin.
• Vitamin C supplements should be used cautiously as high doses can potentially alter the effectiveness of amoxicillin.
• Caffeinated beverages like coffee and tea may increase the elimination of amoxicillin from the body, which could reduce its effectiveness.
• Spicy foods may increase the risk of stomach irritation, especially when combined with this medication.

Co-Amoxiclav 156.25mg/5ml Syrup/Suspension should be stored in a cool and dry environment, ideally at room temperature, ensuring protection from direct sunlight and moisture. Keep the medication securely sealed within its original packaging to maintain its integrity and prevent contamination. Avoid storage in bathrooms or proximity to heat sources like ovens or heaters, as temperature fluctuations can impact its effectiveness. Dispose of any remaining or expired syrup responsibly; refrain from flushing it or pouring it down the drain. Consult your pharmacist or healthcare professional for appropriate disposal practices. Lastly, ensure the medication is stored out of children's reach to prevent accidental consumption.

Following are the quick tips for Co-Amoxiclav 156.25mg/5ml Syrup/Suspension:

• Always follow the dosage instructions provided by your doctor or pharmacist.
• Ensure you measure the correct amount using the measuring cup or spoon provided.
• Administer the syrup directly into your child's mouth or mix it with a small amount of liquid or soft food if they prefer.
• Encourage your child to drink plenty of fluids while taking this medication.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Do not use the medication if it has expired; check the expiration date before each use.
• Contact your healthcare provider if you notice any unusual or persistent side effects during treatment.

Co-Amoxiclav 375mg is a prescription medication that contains a combination of amoxicillin and clavulanic acid, and it is typically used to treat certain bacterial infections. It is crucial for you to disclose any allergies you have to your healthcare provider, as well as if you have a history of mononucleosis, asthma, or liver or kidney disease. Depending on the type of infection being treated, your doctor may recommend regular blood tests to monitor your kidney function and the levels of amoxicillin in your blood. Other common lab tests that may be required periodically include blood counts, liver function tests, and clotting factors. The specific lab tests needed will depend on your medical history and response to the medication, and it is important to follow your healthcare provider's instructions regarding the dosage, duration of treatment, and any monitoring procedures recommended. It is pertinent that you consult your healthcare provider if you have any questions or concerns regarding your lab test requirements while taking this medication.