Tetagama P (250IU) 1 Pre-Filled Syringe Injection

Human Tetanus Immunoglobulin (HTIG) is a passive immunization agent that provides rapid but short-term protection against tetanus. Its mechanism of action involves the administration of antibodies specific to the tetanus toxin, which are derived from human donors with high antibody titers. These antibodies neutralize the tetanus toxin by binding to it, preventing its attachment to nerve endings and inhibiting its neurotoxic effects. The immunoglobulin directly blocks the action of tetanus toxin, thereby preventing the progression of tetanus symptoms and providing immediate protection, especially in individuals who have not developed active immunity or have incomplete vaccination status.

Immunoglobulin is an Immunoglobulin.

Syringe

The following are the uses of Human Tetanus Immunoglobulin Syringe:

• Used for immediate, short-term protection against tetanus in wound management
• Used to neutralize tetanus toxins in contaminated wounds
• Used in patients with deep, penetrating injuries, especially those with foreign bodies or devitalized tissue
• Used in individuals with incomplete or uncertain vaccination history
• Used as a prophylactic measure for high-risk wounds in remote areas where medical care is limited
• Used to prevent tetanus in patients with known sensitivity to tetanus toxoid or vaccine
• Used as an adjunct to tetanus vaccination to provide rapid passive immunity

In the case of an overdose of Human Tetanus Immunoglobulin Syringe, it is important to remain calm and seek medical advice promptly. While overdoses are rare, potential side effects may include mild fever, headache, or pain at the injection site. If symptoms persist or worsen, contact a healthcare professional for guidance. They will provide appropriate care and ensure the well-being of the individual affected by the overdose.

In the case of a missed dose of Human Tetanus Immunoglobulin Syringe, it is important to contact your healthcare provider or seek medical advice promptly. Do not attempt to administer the missed dose without guidance. Your healthcare provider will likely advise you on the appropriate course of action, which may involve rescheduling the dose or adjusting the overall treatment plan. It is crucial to follow their instructions to ensure the effectiveness of the medication and your safety.

To administer the Human Tetanus Immunoglobulin Syringe, ensure the injection site is clean, insert the needle at a 90-degree angle, slowly inject the prescribed dose, and then safely dispose of the syringe according to medical guidelines.

Here are the situations when Human Tetanus Immunoglobulin Syringe should not be used:

• Do not use if the patient has a history of allergic reactions to human immune globulin or any of its components, including excipients.
• Avoid using in individuals with a known sensitivity to thimerosal (a preservative).
• Contraindicated in individuals with a history of anaphylactic or severe systemic reactions to tetanus toxoid or any other component of the vaccine.
• Should not be administered to individuals with a history of IgA deficiency, as Human Tetanus Immunoglobulin may contain trace amounts of IgA.
• Not recommended for patients with a history of thrombosis or thromboembolic disorders, as it may increase the risk of clotting.
• Do not use if the patient has a history of severe localized or systemic reactions following previous administration of human immune globulin.
• Avoid using in patients with severe renal impairment or kidney disease, as it may affect their ability to process the medication.
• Do not inject if the syringe or the solution shows signs of discoloration, cloudiness, or particulate matter.

The side effects of Human Tetanus Immunoglobulin Syringe may include:

• Pain, swelling, or redness at the injection site
• Headache
• Nausea and vomiting
• Fatigue
• Muscle aches
• Joint pain
• Fever
• Allergic reactions (such as rash, itching, or difficulty breathing)

Following are the precautions and warnings for Human Tetanus Immunoglobulin Syringe:

• Not recommended for individuals with a history of hypersensitivity or severe allergic reactions to human immune globulin products.
• May contain trace amounts of blood group antibodies which could potentially cause rare, mild systemic reactions or very rare, severe reactions like anaphylaxis.
• Should be administered cautiously to individuals with a history of thrombosis or risk factors for thrombosis, as it may increase the risk of clotting.
• Diabetic patients should be aware that the product contains small amounts of sugar.
• Some products may contain trace amounts of IgA, which could potentially cause allergic reactions in individuals with IgA deficiency.
• May interfere with the response to live virus vaccines such as measles, mumps, and rubella; consider deferring such vaccinations for several months after Human Tetanus Immunoglobulin administration.
• Not recommended for routine prophylaxis against tetanus; should be used only in specific circumstances as recommended by a healthcare professional.

Following are the drug interactions for Human Tetanus Immunoglobulin Syringe:

• Immunoglobulin may impair the effectiveness of live virus vaccines such as measles, mumps, and rubella due to antibody interference.
• May increase the risk of viral transmission and volume overload.
• Can interfere with the action of anticoagulants, requiring close monitoring of coagulation parameters.
• May reduce the effectiveness of immunosuppressant medications by neutralizing their effects.
• Concurrent use might reduce the efficacy of Human Tetanus Immunoglobulin.
• Immunoglobulin products may increase the risk of methotrexate toxicity.
• Immunoglobulin can potentially interfere with the immune response to vaccines, reducing their effectiveness.

Following are the food interactions for Human Tetanus Immunoglobulin Syringe:

• Avoid consuming alcohol as it can interfere with the medication's effectiveness and increase the risk of side effects.
• Grapefruit and grapefruit juice should be consumed with caution as they may interact with the medication, potentially affecting its absorption and metabolism.
• Dairy products, especially milk, may reduce the absorption of this medication. Consider separating milk intake from medication by a few hours.
• High-fat meals can delay the absorption of this medication, so it is best to avoid fatty foods before taking the injection.
• Avoid caffeine-rich beverages like coffee and energy drinks as they may enhance the medication's stimulatory effects.
• Certain protein-rich foods like meat and beans can affect the absorption of this medication, so ensure a balanced diet without excessive protein intake.
• Spicy foods may increase the risk of injection site reactions, so consider reducing spicy food intake after the Human Tetanus Immunoglobulin injection.
• Stay well-hydrated before and after the injection, but avoid excessive fluid intake as it may affect the medication's distribution.

Storage and disposal of Human Tetanus Immunoglobulin Syringe should be done with caution to maintain its effectiveness and ensure safety. Store the syringe in a refrigerator at a temperature between 2°C and 8°C (36°F and 46°F), protecting it from light and moisture. Avoid freezing the solution as it may affect its potency. Keep the syringe in its original packaging until ready for use, ensuring the integrity of the seal. Do not use if the solution appears discolored or contains particles. Dispose of any unused or expired medication responsibly; do not throw it into the regular trash or pour it down the drain. Contact your healthcare provider or pharmacist for guidance on proper disposal methods, and keep the syringe out of the reach of children to prevent accidental exposure.

Following are the quick tips for Human Tetanus Immunoglobulin Syringe:

• Store the syringe as directed by your healthcare provider, typically in a refrigerator.
• Ensure the syringe is not frozen, and protect it from light.
• Check for any discoloration or particles before use.
• Do not use if the syringe is damaged or leaking.
• Use a new needle and syringe for each injection.
• Dispose of used needles and syringes safely in a sharps container.
• Seek immediate medical attention if you experience any severe allergic reactions.