TEZOX 250MG

Ceftizoxime is a third-generation cephalosporin antibiotic that exerts its bactericidal effect by inhibiting cell wall synthesis in susceptible bacteria. Its primary mechanism of action involves binding to and inhibiting essential enzymes called penicillin-binding proteins (PBPs), which are crucial for cross-linking peptidoglycan strands during cell wall formation. By selectively targeting these PBPs, ceftizoxime disrupts the structural integrity of the bacterial cell wall, leading to cell lysis and death. This selective interference with bacterial cell wall synthesis makes ceftizoxime highly effective against a broad spectrum of Gram-positive and Gram-negative bacteria, including many common pathogens responsible for various infections.

Ceftizoxime 250mg

Third-generation cephalosporin.

injection

The following are the uses of Ceftizoxime 250mg injection:

• Used for treating severe bacterial infections like pneumonia, skin and soft tissue infections, and urinary tract infections.
• Used for surgical patients to prevent infection.
• Used for bacterial meningitis, ensuring the bacteria causing the infection is susceptible.
• Used for bone and joint infections, providing effective coverage against common pathogens.
• Used for intra-abdominal infections, offering broad-spectrum coverage.
• Used for bloodstream infections, requiring prompt intervention.
• Used for hospital-acquired infections, targeting resistant bacteria.

In the case of an overdose of Ceftizoxime 250mg injection, prompt medical attention is necessary. Overdose symptoms may include severe nausea, vomiting, diarrhea, and potentially dangerous changes in blood pressure. It is important to seek medical assistance immediately if an overdose is suspected, as healthcare professionals can provide appropriate treatment and monitoring to manage any adverse effects and ensure the patient's safety. Timely intervention can help mitigate the risks associated with excessive medication intake.

In the case of a missed dose of Ceftizoxime 250mg injection, it is important to administer the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to adjust your dosing schedule to ensure the best treatment outcome. It is crucial to maintain a consistent medication routine for the effectiveness of the treatment.

To administer Ceftizoxime 250mg injection, clean the injection site, insert the needle at a 90-degree angle, and inject the entire content of the vial slowly, ensuring proper dosage as prescribed by your healthcare provider.

Here are the conditions and situations when Ceftizoxime 250mg injection should not be used:

• Avoid if you have a known allergy to Ceftizoxime or any other cephalosporin antibiotics.
• Do not use if you have a history of severe allergic reactions to penicillin-type medications.
• Contraindicated in patients with a history of cholestatic jaundice/hepatic dysfunction associated with prior cephalosporin use.
• Should not be used if you have severe kidney disease without dialysis.
• Not recommended for patients with untreated bacterial meningitis.
• Avoid in cases of severe gastrointestinal diseases, especially those with a history of colitis.
• Do not administer if there is a suspicion or confirmation of infection caused by penicillin-resistant pneumococci.

The side effects of Ceftizoxime 250mg injection may include:

• Nausea and vomiting
• Diarrhea
• Skin rash or itching
• Allergic reactions (hives, swelling, difficulty breathing)
• Pain or irritation at the injection site
• Headache
• Dizziness
• Changes in liver function tests

Following are the precautions and warnings for Ceftizoxime 250mg Injection:

• Not suitable for patients with hypersensitivity to cephalosporins or penicillins, as cross-reactivity may occur.
• Caution is required in patients with renal impairment, as dosage adjustments may be necessary to prevent toxicity.
• May cause Clostridium difficile-associated diarrhea; discontinue use if severe diarrhea occurs and seek medical attention.
• Use with caution in patients with a history of gastrointestinal diseases, particularly colitis, as it may exacerbate symptoms.
• Intravenous administration should be done under medical supervision to avoid injection site reactions such as pain, redness, or swelling.
• Prolonged use may lead to fungal or bacterial superinfections, including resistant organisms.
• Liver and kidney function should be monitored in patients receiving prolonged therapy.
• May interfere with laboratory tests, such as urine glucose tests, leading to false-positive results.
• Use during pregnancy and breastfeeding should be done only if the potential benefits outweigh the risks, as safety data is limited.
• Patients should report any signs of an allergic reaction, including rash, itching, swelling, or difficulty breathing, to their healthcare provider immediately.

Following are the drug interactions for Ceftizoxime 250mg injection:

• Probenecid can decrease the renal excretion of ceftizoxime, potentially increasing its blood levels.
• Nephrotoxicity risk may be increased when used with other nephrotoxic drugs like aminoglycosides or diuretics.
• Concurrent use with valproic acid may increase the risk of hyperbilirubinemia.
• May reduce the effectiveness of oral contraceptives, so additional contraception is recommended.
• Ceftizoxime may decrease the efficacy of live bacterial vaccines (e.g., typhoid vaccine).
• Can alter the effects of anticoagulants, requiring close monitoring of coagulation parameters.
• Potentially decreases the effectiveness of uticaria-treating drugs like histamine H1 antagonists.

Following are the food interactions for Ceftizoxime 250mg injection:

• Avoid alcohol consumption during and after treatment to prevent potential side effects and liver complications.
• Ensure adequate fluid intake to maintain hydration and aid in the elimination of the medication.
• Ceftizoxime should be administered on an empty stomach, preferably 1 hour before or 2 hours after meals, for optimal absorption.
• Avoid high-fat meals as they may delay the absorption of the medication.
• Grapefruit and grapefruit juice should be avoided as they can interfere with the metabolism of the drug, potentially leading to increased side effects.
• Do not consume dairy products simultaneously with the medication, as calcium can bind to the antibiotic, reducing its effectiveness.
• Patients should maintain a balanced diet to support overall health and recovery during the course of treatment.

Ceftizoxime 250mg injection should be stored in a controlled environment, preferably in a cool and dry place at room temperature (between 20°C to 25°C). Protect the injection vials from direct exposure to sunlight, heat, and moisture, as these factors can degrade the medication. Ensure the vials are kept in their original packaging, tightly sealed, to maintain sterility and prevent contamination. It is crucial to dispose of any unused or expired Ceftizoxime injection properly; do not discard it in regular household waste or pour it down the drain. Contact your pharmacist or healthcare provider for instructions on safe disposal methods. Keep this medication out of children's reach to prevent accidental ingestion.

Following are the quick tips for Ceftizoxime 250mg injection:

• Administer the injection under medical supervision for optimal therapeutic effect.
• Ensure the injection is prepared and administered by trained medical professionals.
• The injection should be given slowly, over 3-5 minutes, to minimize discomfort.
• Rotate injection sites to reduce the risk of tissue irritation.
• Avoid rapid infusion as it may cause nausea and vomiting.
• Report any signs of allergic reaction immediately to your healthcare provider.
• Store the injection at room temperature, away from direct sunlight and moisture.