THEODUR 300MG TAB

Theophylline 300mg tablets primarily exert their therapeutic effects through multiple mechanisms of action. As a methylxanthine derivative, theophylline relaxes smooth muscles and exhibits bronchodilatory properties. It achieves this by inhibiting phosphodiesterase enzymes, leading to increased intracellular concentrations of cyclic adenosine monophosphate (cAMP). Elevated cAMP levels subsequently result in smooth muscle relaxation, particularly in the airways, thereby improving airflow and reducing airway resistance. Additionally, theophylline enhances the force of contraction of the diaphragm, further contributing to improved respiratory function. Theophylline also acts as a non-selective adenosine receptor antagonist, which may contribute to its bronchodilatory and anti-inflammatory effects. This mechanism of action makes theophylline effective in the management of respiratory conditions, particularly in maintaining airway patency and alleviating respiratory distress.

Bronchodilator

Tablet

The following are the uses of Theophylline 300mg Tablet:

• Used for treating respiratory issues like chronic asthma and chronic bronchitis.
• Used to relax and open up the airways, making breathing easier.
• Used for managing symptoms such as wheezing, coughing, and shortness of breath.
• Used to reduce the frequency and severity of asthma attacks.
• Used for improving lung function and overall breathing capacity.
• Used to prevent nighttime asthma symptoms, ensuring better sleep.
• Used for both long-term asthma control and quick relief during flare-ups.

In the case of an overdose of Theophylline 300mg Tablets, prompt medical attention is necessary. Symptoms may include severe nausea, vomiting, abdominal pain, rapid heartbeat, seizures, and confusion. If an overdose is suspected, seek emergency medical help immediately. Treatment involves managing symptoms and ensuring the patient's vital signs are stable. It is crucial to act quickly and not delay seeking medical assistance to prevent potentially life-threatening complications.

In the case of a missed dose of Theophylline 300mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication regimen. It is generally recommended to take the missed dose within a 2-hour window of the scheduled time for optimal effectiveness.

To take Theophylline 300mg Tablets, swallow the tablet whole with a full glass of water, usually two or three times a day, or as directed by your healthcare professional, ensuring you follow the prescribed dosage and schedule provided.

Here are the situations when Theophylline 300mg Tablet should not be taken:

• Avoid using if you have a known allergy or hypersensitivity to Theophylline or related xanthine medications such as caffeine, theobromine, or aminophylline.
• Do not use if you have a history of seizures, as Theophylline may lower the seizure threshold.
• Contraindicated in individuals with severe heart conditions, including unstable angina or recent heart attack.
• Should not be taken if you have a stomach ulcer or gastrointestinal bleeding.
• Avoid using if you have severe liver disease or cirrhosis, as it can affect drug metabolism.
• Not recommended for individuals with severe hyperthyroidism, as it may increase heart rate and blood pressure.
• Do not use if you have a rare hereditary condition known as porphyria.
• Contraindicated in patients with a history of a rare muscle disorder called rhabdomyolysis.

The side effects of Theophylline 300mg Tablet may include:

• Nausea and vomiting
• Headache
• Rapid or irregular heartbeat (palpitations)
• Nervousness and restlessness
• Insomnia (difficulty sleeping)
• Tremors or shaking
• Gastrointestinal issues like diarrhea or stomach pain
• Muscle twitching

Following are the precautions and warnings for Theophylline 300mg Tablet:

• This medication should be used with caution in patients with a history of seizures, as it may lower the seizure threshold.
• It is important to monitor blood levels of Theophylline regularly to ensure they remain within the therapeutic range, as overdose can lead to serious side effects.
• Patients with liver or heart disease should be closely monitored as they may be more susceptible to adverse effects.
• Avoid alcohol consumption while taking this medication as it can increase the risk of side effects.
• Theophylline may interact with other medications; inform your doctor about all the medications you are taking to prevent potential drug interactions.
• Do not stop taking this medication suddenly without consulting your doctor, as it may cause withdrawal symptoms.
• Patients with a history of peptic ulcers or gastrointestinal bleeding should exercise caution, as Theophylline may exacerbate these conditions.

Following are the drug interactions for Theophylline 300mg Tablet:

• Erythromycin, clarithromycin, and other macrolide antibiotics can increase Theophylline levels, leading to potential toxicity.
• Cimetidine and other H2-receptor antagonists may increase Theophylline concentrations in the body, requiring dose adjustments.
• Phenytoin, carbamazepine, and rifampicin can induce Theophylline metabolism, reducing its effectiveness.
• Oral contraceptives may decrease Theophylline clearance, leading to higher blood levels.
• Quinolone antibiotics, such as ciprofloxacin, can inhibit Theophylline metabolism, requiring close monitoring.
• Beta-blockers, like propranolol, may mask certain signs of Theophylline toxicity, making dosage adjustments necessary.
• Theophylline may interact with lithium, increasing the risk of lithium toxicity and requiring careful monitoring of lithium levels.

Following are the food interactions for Theophylline 300mg Tablet:

• Avoid consuming excessive amounts of caffeine as it can increase the stimulant effects of Theophylline, leading to potential side effects like restlessness, tremors, and an increased heart rate.
• Grapefruit and grapefruit juice should be consumed with caution as they can inhibit the enzyme CYP1A2, which is responsible for metabolizing Theophylline, potentially leading to increased drug levels in the blood.
• Limit the intake of fatty meals as high-fat foods can slow down the absorption of Theophylline, affecting its effectiveness.
• Alcohol should be avoided or consumed in moderation as it can enhance the sedative effects of Theophylline, causing increased drowsiness and dizziness.
• Avoid consuming large amounts of chocolate, especially dark chocolate, as it contains a compound called theobromine, which can interact with Theophylline and potentially increase its stimulant effects.
• Green tea and other herbal teas with caffeine or similar compounds should be consumed in moderation, as they may interact with Theophylline and affect its metabolism.
• Consult your healthcare provider regarding the consumption of foods rich in vitamin C, as high doses of vitamin C may alter Theophylline's effectiveness.
• Always follow the dosage instructions provided by your healthcare professional to ensure the safe and effective use of Theophylline tablets.

Theophylline 300mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. It is crucial to keep the medication in its original container, tightly sealed, to maintain its integrity and prevent contamination. Avoid exposing the tablets to extreme temperatures, including heat sources like radiators or direct sunlight, as this can impact their effectiveness. When disposing of unused or expired tablets, do not flush them down the toilet or drain; instead, consult a pharmacist or healthcare professional for guidance on proper disposal methods. Always exercise caution to keep the medication out of children's reach to prevent unintended consumption. Regularly check the expiration date, and remember that proper storage and disposal are vital for the safe and effective use of Theophylline 300mg Tablets.

Following are the quick tips for Theophylline 300mg Tablet:

• Consult your doctor for the right dosage and duration based on your medical condition.
• Take the tablet as a whole, do not crush or chew.
• Maintain a consistent schedule for taking the medication as prescribed.
• Avoid missing doses, but if you do, take it as soon as you remember, unless it's almost time for the next dose.
• Do not double the dose to make up for a missed one.
• Inform your doctor about all your current medications to avoid potential interactions.
• Store the medication at room temperature, away from moisture and heat.