Theograd (350mg) 100 Tablets

Theophylline is a methylxanthine that has a bronchodilator effect. Its mechanism of action involves multiple pathways. Firstly, it relaxes airway smooth muscles by inhibiting phosphodiesterase enzymes, leading to increased intracellular levels of cyclic adenosine monophosphate (cAMP). This elevation in cAMP reduces the phosphorylation of the myosin light chain, resulting in smooth muscle relaxation and bronchodilation. Additionally, theophylline antagonizes adenosine receptors, which contributes to its bronchodilatory effect by further promoting cAMP production and inhibiting the release of bronchoconstricting mediators. Theophylline also enhances the force of contraction of the diaphragm by sensitizing it to calcium, thereby improving respiratory muscle function.

Bronchodilator.

Tablet

The following are the uses of Theophylline 350mg Tablet:

• Used for treating asthma and chronic obstructive pulmonary disease (COPD).
• Used to relax the airways and make breathing easier.
• Used for long-term management of respiratory conditions.
• Used to reduce inflammation in the airways.
• Used for preventing asthma attacks and managing symptoms.
• Used to improve lung function and overall breathing capacity.
• Used for patients who require additional control over their respiratory condition.

In the case of an overdose of Theophylline 350mg Tablets, individuals may experience severe symptoms such as rapid heartbeat, nausea, vomiting, and seizures. It is crucial to recognize the signs of overdose promptly and seek medical assistance immediately. The severity of symptoms can vary, and medical professionals should be contacted for guidance, as they can provide specific instructions and treatment to manage the overdose effectively and ensure the patient's safety. Timely action is essential to prevent potential complications.

In the case of a missed dose of Theophylline 350mg Tablet, it is generally advised to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is recommended to skip the missed dose and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, it is best to discuss this with your healthcare provider to determine the best course of action.

To take Theophylline 350mg Tablet, swallow the tablet whole with a full glass of water, preferably on an empty stomach, exactly as prescribed by your healthcare provider, typically twice a day, and follow the dosing schedule provided to ensure optimal effectiveness.

Here are the conditions and situations when Theophylline 350mg Tablet should not be taken:

• Avoid using Theophylline if you have a known allergy or sensitivity to Theophylline or related xanthine medications such as caffeine or theobromine.
• Do not use if you have a history of seizures or conditions that increase the risk of seizures, as Theophylline may lower the seizure threshold.
• Contraindicated in individuals with a history of peptic ulcer disease or active gastric ulcers, as it can stimulate gastric acid secretion.
• Should not be used in patients with severe cardiovascular disease, as it may increase heart rate and blood pressure.
• Avoid using if you have hyperthyroidism, as Theophylline can exacerbate the symptoms.
• Not recommended for individuals with liver disease or impaired liver function, as Theophylline is metabolized by the liver.
• Do not use if you have a history of severe arrhythmias or tachycardia, as Theophylline may exacerbate these conditions.
• Contraindicated in patients with narrow-angle glaucoma, as it can increase intraocular pressure.
• Avoid using Theophylline if you have a history of severe or uncontrolled hypertension (high blood pressure).
• Not suitable for individuals with a history of severe gastrointestinal bleeding or perforation.

The side effects of Theophylline 350mg Tablet may include:

• Nausea and vomiting
• Headache
• Restlessness or insomnia
• Rapid or irregular heartbeat (palpitations)
• Nervousness or anxiety
• Tremors or shaking
• Stomach pain or upset
• Diarrhea

Following are the precautions and warnings for Theophylline 350mg Tablet:

• Do not use if you have a known allergy to Theophylline or related xanthine derivatives.
• Regular monitoring of blood levels is necessary to ensure optimal dosage and prevent toxicity.
• Patients with liver or kidney disease should use with caution as it may require dosage adjustments.
• Avoid excessive consumption of caffeine and alcohol as it can increase side effects.
• Stop the medication and seek medical attention if you experience rapid or irregular heartbeat, severe nausea, or seizures.
• Theophylline may interact with other medications; inform your doctor about all medications you are taking.
• Pregnant and breastfeeding women should consult their healthcare provider before using this medication.

Following are the drug interactions for Theophylline 350mg Tablet:

• Erythromycin, ciprofloxacin, and other antibiotics can increase theophylline levels, leading to potential toxicity.
• Cimetidine and other acid-reducing drugs may decrease theophylline elimination, resulting in higher blood concentrations.
• Phenytoin, carbamazepine, and rifampicin can induce theophylline metabolism, reducing its effectiveness.
• Theophylline may decrease the clearance of certain beta-blockers, such as propranolol, leading to increased beta-blocker levels.
• Concomitant use with oral contraceptives may increase theophylline metabolism, requiring dose adjustments.
• Alcohol can enhance theophylline's side effects, especially on the central nervous system.
• It may interact with other xanthines like caffeine, increasing the risk of adverse effects.

Following are the food interactions for Theophylline 350mg Tablet:

• Avoid consuming excessive amounts of caffeine-containing foods and beverages like coffee, tea, chocolate, and energy drinks, as these can increase the stimulant effects of Theophylline and lead to side effects such as jitters, rapid heartbeat, and insomnia.
• Grapefruit and grapefruit juice should be consumed with caution as they can inhibit the enzyme CYP1A2, leading to increased levels of Theophylline in the blood and potentially causing adverse effects.
• Alcohol may enhance the sedative effects of Theophylline, so it is advisable to limit or avoid alcohol consumption during treatment.
• High-fat meals can delay the absorption of Theophylline, potentially affecting its effectiveness. It is best to take the medication on an empty stomach or as directed by your healthcare professional.
• Avoid large meals rich in carbohydrates, especially those with a high glycemic index, as they can increase the elimination of Theophylline from the body, reducing its effectiveness.
• Some herbal supplements, like St. John's Wort, may interact with Theophylline, affecting its metabolism. Consult your doctor before taking any herbal remedies.
• Ensure a balanced diet, as Theophylline may decrease appetite, and maintaining proper nutrition is essential.
• Always follow the advice of your healthcare provider regarding dietary considerations and medication adjustments.

Theophylline 350mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring it is protected from heat, moisture, and direct sunlight. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. It is crucial not to store them in the bathroom or near heat-emitting appliances. Always check the expiration date, and never use the medication beyond this date. For disposal, avoid flushing or pouring the tablets down the drain; instead, consult a pharmacist or healthcare professional for guidance on proper disposal methods. Keep the medication securely stored, out of children's reach, to prevent accidental consumption.

Following are the quick tips for Theophylline 350mg Tablet:

• Ensure you take the tablet as directed by your doctor, typically twice a day, 12 hours apart.
• Take the tablet on an empty stomach, at least 1 hour before or 2 hours after meals, for optimal absorption.
• Maintain a consistent daily routine for taking the medication to ensure its effectiveness.
• Avoid activities that require mental alertness until you know how this medicine affects you.
• If you experience mild stomach upset, try taking the tablet with food.
• Stay hydrated and drink plenty of fluids while taking this medication.
• Store the tablets at room temperature, away from moisture and direct sunlight.