Ticlid (250mg) 20 Tablets

Ticlopidine 250mg Tablet primarily exerts its antiplatelet effects through the inhibition of platelet aggregation. It achieves this by blocking the binding of adenosine diphosphate (ADP) to its P2Y12 receptors on platelets. This inhibition prevents the activation of glycoprotein IIb/IIIa complex, a crucial step in the final common pathway of platelet aggregation. By interfering with this process, ticlopidine effectively reduces the risk of thrombotic events by impairing the ability of platelets to aggregate and form clots.

Platelet aggregation inhibitor

Tablet

The following are the uses of Ticlopidine 250mg Tablet:

• Used for preventing blood clots in patients who have had a stroke or are at risk of having a stroke.
• Used to treat peripheral arterial disease, improving blood flow to the legs and feet.
• Used to reduce the risk of blood clots forming after certain types of heart surgeries.
• Used to prevent blood clots in individuals with a medical condition called TTP (Thrombotic Thrombocytopenic Purpura).
• Used for managing chest pain and reducing the risk of heart attacks in certain patients.
• Used to prevent blood clots in people with poor blood circulation, especially in the legs.
• Used as an alternative for patients who cannot take aspirin or other antiplatelet medications.

In the case of an overdose of Ticlopidine 250mg Tablets, individuals may experience symptoms such as excessive bleeding, easy bruising, or prolonged bleeding from minor cuts. Other potential signs include a persistent headache, dizziness, or fatigue. It is crucial to seek medical advice promptly if an overdose is suspected. The doctor may recommend immediate treatment options to mitigate the effects, including gastric lavage or administering activated charcoal to reduce further absorption of the medication.

In the case of a missed dose of Ticlopidine 250mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare professional for advice on how to safely resume your medication regimen without compromising its effectiveness.

To take Ticlopidine 250mg Tablet, swallow the tablet whole with a full glass of water, preferably with food, following the dosage instructions provided by your healthcare professional, typically taken twice a day, 12 hours apart.

Following are the conditions/situations when Ticlopidine 250mg Tablet should not be taken:

• Should not be used in individuals with a known allergy to Ticlopidine or any of its components.
• Contraindicated in patients with a history of severe blood disorders, such as severe neutropenia or thrombocytopenia.
• Not recommended for individuals with active bleeding, such as a stomach ulcer or bleeding in the brain.
• Should not be used in patients with severe liver disease or impaired liver function.
• Contraindicated in individuals with uncontrolled or severe hypertension (high blood pressure).
• Not suitable for patients with a history of seizures or epilepsy.
• Should be avoided in patients with a recent history of stroke or transient ischemic attack (TIA).
• Contraindicated during pregnancy or breastfeeding.
• Not recommended for individuals with a history of gastrointestinal ulceration or bleeding.
• Should not be used in patients with severe kidney disease or those undergoing dialysis.

The side effects of Ticlopidine 250mg Tablet may include:

• Diarrhea
• Nausea and vomiting
• Stomach pain or cramps
• Skin rashes or itching
• Headache
• Dizziness or lightheadedness
• Unusual bleeding or bruising
• Fever or chills

Following are the precautions and warnings for Ticlopidine 250mg Tablet:

• This medication should be used with caution in patients with pre-existing blood disorders, as it may affect blood cell counts.
• Regular blood tests are required to monitor blood cell counts and liver function while on this medication.
• Patients with a history of liver or kidney disease should exercise caution and consult a doctor, as dosage adjustments might be necessary.
• Ticlopidine may increase the risk of bleeding, so patients should inform their doctor if they have a bleeding disorder or are taking other medications that affect blood clotting.
• Avoid activities that may result in bruising or injury, as the drug can make you more prone to bleeding and bruising.
• Elderly patients may be more sensitive to the side effects, particularly bleeding-related complications.
• Not recommended for individuals with active bleeding, severe liver or kidney impairment, or a history of hematological disorders.
• Always inform your healthcare provider about all the medications you are taking to avoid potential drug interactions.

Following are the drug interactions for Ticlopidine 250mg Tablet:

• Ticlopidine can interact with other antiplatelet agents like aspirin, clopidogrel, or warfarin, increasing the risk of bleeding. Close monitoring is required.
• It may reduce the metabolism of phenytoin, leading to increased phenytoin levels and potential toxicity. Adjustments in dosage may be necessary.
• Ticlopidine can affect the metabolism of theophylline, possibly increasing its levels and associated side effects.
• Caution is advised with medications metabolized by CYP2C19, as Ticlopidine may inhibit this enzyme, altering their effectiveness.
• The risk of bleeding may be elevated when taken with nonsteroidal anti-inflammatory drugs (NSAIDs).
• Antacids may reduce the absorption of Ticlopidine, so separate administration is recommended.
• Probenecid may increase plasma concentrations of Ticlopidine, potentially requiring dosage adjustments.

Following are the food interactions for Ticlopidine 250mg Tablet:

• Consuming grapefruit or grapefruit juice should be avoided as it can interfere with the metabolism of Ticlopidine, leading to increased drug levels in the blood and potentially causing adverse effects.
• Alcohol intake should be minimized or avoided as it may increase the risk of bleeding when combined with Ticlopidine, due to its platelet-inhibiting properties.
• Avoid high-fat meals as they can potentially reduce the absorption of Ticlopidine, affecting its effectiveness.
• Limit caffeine consumption as it may enhance the effects of Ticlopidine on platelet function, increasing the risk of bleeding.
• Foods rich in vitamin K, like leafy green vegetables, should be consumed consistently as Ticlopidine may interfere with vitamin K metabolism, affecting blood clotting.
• Avoid excessive use of salt substitutes containing potassium, as Ticlopidine may increase potassium levels, which can be harmful to some individuals.
• Maintain a balanced diet to support overall health, as Ticlopidine may impact nutrient absorption.

Ticlopidine 250mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. The original container should be tightly sealed to maintain its integrity and prevent contamination. It is crucial to keep this medication away from heat sources like radiators or ovens, as extreme temperatures can compromise its effectiveness. Regularly check the expiration date, and if the tablets are no longer needed or have expired, proper disposal is essential. Avoid flushing or pouring them down the drain; instead, consult a pharmacist or healthcare professional for guidance on safe disposal methods. Lastly, store the medication securely to prevent access by children, as accidental ingestion can be harmful.

Following are the quick tips for Ticlopidine 250mg Tablet:

• Consult your doctor before starting this medication, especially if you have a history of blood disorders or liver/kidney problems.
• Take the tablet as directed by your doctor, usually twice a day with meals.
• Swallow the tablet whole with a full glass of water; do not crush, chew, or break it.
• Maintain a consistent medication schedule and avoid missing doses for best effectiveness.
• Do not take this medication with grapefruit juice, as it may affect how the drug works.
• Regular blood tests are required to monitor your blood cell counts while on this medication.
• Inform your doctor about all medications you are taking to prevent potential drug interactions.