TIMENTIN 3.2G IV INJ

Ticarcillin injection, a semi-synthetic penicillin antibiotic, exerts its bactericidal effect by inhibiting bacterial cell wall synthesis. It primarily targets penicillin-binding proteins (PBPs), which are essential for cross-linking peptidoglycan strands in the bacterial cell wall. By binding to these PBPs, ticarcillin disrupts the formation of a strong and protective cell wall, leading to cell lysis and death. This mechanism is particularly effective against susceptible Gram-negative and some Gram-positive bacteria, as it interferes with their ability to maintain structural integrity and withstand osmotic pressure. Ticarcillin's selective toxicity towards bacterial cells makes it a valuable tool in combating various bacterial infections.

Penicillin antibiotic.

Injection

The following are the uses of Ticarcillin Injection:

• Used for treating severe infections caused by susceptible bacteria, particularly in the respiratory tract, skin, and soft tissues.
• Used for managing infections in patients with low immune function or those undergoing surgery.
• Used for combating bacterial infections in various body systems, including the urinary tract and abdomen.
• Used for treating septicemia (bloodstream infections) and endocarditis (heart valve infections).
• Used for preventing infection in high-risk situations, such as before major surgeries.
• Used for controlling infections in patients with neutropenia (low white blood cell count).
• Used for treating infections in patients allergic to other types of penicillin antibiotics.

In the case of an overdose of Ticarcillin Injection, immediate medical attention is necessary. Symptoms may include gastrointestinal disturbances, such as nausea, vomiting, and diarrhea, as well as neurological effects like seizures or dizziness. Promptly seek medical care, and provide healthcare professionals with information about the quantity ingested, the time of overdose, and any observed symptoms to ensure appropriate treatment and management of potential complications.

In the case of a missed dose of Ticarcillin Injection, it is important to administer the missed dose as soon as possible. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume the medication and ensure optimal treatment.

To administer the Ticarcillin Injection, gently swirl the vial to ensure the powder is fully dissolved, draw the reconstituted solution into a syringe, and inject it into the muscle or intravenous line as directed by your healthcare professional, following proper aseptic techniques.

Here are the conditions or situations when Ticarcillin Injection should not be used:

• Avoid if you have a history of severe allergic reactions to penicillin antibiotics or any other beta-lactam antibiotics.
• Do not use if you have mononucleosis or lymphatic leukemia.
• Contraindicated in patients with a history of cholestatic jaundice/hepatic dysfunction associated with ticarcillin therapy.
• Should not be used if you have severe kidney disease or conditions like epilepsy or Parkinson's disease.
• Not recommended for individuals with a history of gastrointestinal diseases, especially colitis, enteritis, or severe diarrhea.
• Avoid using if you have a history of severe or multiple allergies, asthma, or hay fever.
• Do not administer if the patient has shown hypersensitivity to any of the components in the injection.

The side effects of Ticarcillin Injection may include:

• Skin rash or itching
• Diarrhea
• Nausea and vomiting
• Fever
• Injection site reactions (such as pain, swelling, or redness)
• Allergic reactions (such as hives, itching, or difficulty breathing)
• Vaginal itching or discharge
• Superinfections (new or worsening infections)

Following are the precautions and warnings for Ticarcillin Injection:

• This medication should not be administered to individuals with a history of allergic reactions to ticarcillin, penicillin, or any other beta-lactam antibiotics.
• Prolonged use may lead to the overgrowth of resistant microorganisms, and patients should be carefully monitored for signs of superinfection.
• Renal function should be monitored during prolonged therapy, and dosage adjustments may be necessary in patients with impaired kidney function.
• Caution is advised in patients with a history of gastrointestinal diseases, as ticarcillin may cause diarrhea or other gastrointestinal disturbances.
• It should be used with caution in patients with a history of seizures or other neurological disorders, as it may increase the risk of seizures.
• Ensure adequate hydration and urine output during treatment, especially in patients with pre-existing kidney issues.
• Patients should be advised to complete the full course of treatment, even if they feel better before the medication is finished.
• Pregnant and breastfeeding women should only use this medication if the potential benefits outweigh the risks, and under the supervision of a healthcare professional.

Following are the drug interactions for Ticarcillin Injection:

• Probenecid can decrease renal tubular secretion of ticarcillin, leading to increased serum levels and potential toxicity.
• Allopurinol may increase the risk of skin rash when used with ticarcillin.
• Concurrent use with aminoglycosides may enhance bactericidal activity, but nephrotoxicity risk is also increased.
• Oral anticoagulants' effects can be altered, requiring close monitoring of prothrombin time.
• High doses of ticarcillin may interfere with certain types of live attenuated virus vaccines, such as measles, mumps, and rubella.
• Diuretics, such as furosemide, can reduce the effectiveness of ticarcillin by decreasing its renal excretion.
• May decrease the effectiveness of oral contraceptives, requiring additional contraceptive measures.

Following are the food interactions for Ticarcillin Injection:

• Avoid consuming alcohol during treatment with Ticarcillin as it may increase the risk of liver-related side effects and gastrointestinal issues.
• Grapefruit and grapefruit juice should be consumed with caution as they can inhibit the metabolism of Ticarcillin, potentially leading to increased drug levels in the body.
• High-fat meals may delay the absorption of Ticarcillin, so it is advisable to take the medication on an empty stomach or as directed by your healthcare professional.
• Avoid probenecid-rich foods like spinach, broccoli, and beans, as probenecid can decrease the excretion of Ticarcillin, increasing its levels in the body.
• Avoid herbal supplements like St. John's Wort, as they may affect the metabolism of Ticarcillin, altering its effectiveness.
• Vitamin K-rich foods like leafy green vegetables and liver can potentially reduce the effectiveness of Ticarcillin, so consult your doctor regarding dietary adjustments.
• Limit caffeine intake as it may enhance the side effects of Ticarcillin, especially nervous system stimulation.
• Consult your healthcare provider for specific dietary recommendations, as individual circumstances may require personalized advice.

Ticarcillin Injection should be stored and disposed of with utmost care to ensure safety and maintain its effectiveness. Store the injection in a cool, dry place, preferably at room temperature between 68°F and 77°F (20°C and 25°C), and protect it from light and moisture. Keep the medication in its original packaging, tightly sealed, to prevent contamination. Avoid storing it in the bathroom or near heat sources, as temperature fluctuations can degrade the medicine. Always check the expiration date, and dispose of any unused or expired medication promptly. Proper disposal methods should be followed, such as returning it to a pharmacy or healthcare facility for safe disposal, rather than flushing or pouring it down the drain, as this can cause environmental harm. Keep the injection out of children's reach to prevent accidental exposure.

Following are the quick tips for Ticarcillin Injection:

• Administer the injection under medical supervision for safe and effective use.
• Ensure the injection is prepared and stored as per the instructions provided.
• Follow the prescribed dosage and duration of treatment as directed by your doctor.
• Inform your doctor about all medications you are taking to avoid potential interactions.
• Report any allergic reactions or severe side effects immediately to your healthcare provider.
• Do not reuse needles or syringes; dispose of them safely after use.
• Store the medication properly and keep it out of the reach of children.