Tiovair Rotacaps (18mcg) 30 Capsules

Tiotropium, a long-acting muscarinic antagonist, exerts its mechanism of action by selectively binding to and blocking M3 muscarinic receptors located in smooth muscle cells of the airways. By inhibiting these receptors, tiotropium prevents the activation of smooth muscle contraction, which is typically induced by the neurotransmitter acetylcholine. This blockade leads to bronchodilation, resulting in the relaxation and opening of constricted airways, thereby improving airflow and reducing respiratory symptoms associated with conditions like chronic obstructive pulmonary disease (COPD) and asthma. The specificity of tiotropium for M3 receptors contributes to its effectiveness in maintaining smooth muscle relaxation over an extended period without causing significant side effects in other organs influenced by muscarinic receptors.

anticholinergic bronchodilator.

capsule

The following are the uses of Tiotropium 18mcg Capsule:

• Used for treating chronic obstructive pulmonary disease (COPD), providing long-term relief from symptoms like coughing and shortness of breath.
• Used to relax and open up the airways, making breathing easier for patients with COPD.
• Used to reduce the frequency and severity of COPD exacerbations, helping patients manage their condition.
• Used for maintenance therapy, meaning it's taken regularly to control COPD symptoms over time.
• Used to improve lung function and overall quality of life for individuals with COPD.
• Used as an alternative to short-acting bronchodilators, offering longer-lasting effects.
• Used in combination with other COPD medications as part of a comprehensive treatment plan.

In the case of an overdose of Tiotropium 18mcg Capsules, it is important to recognize the signs, which may include severe dry mouth, difficulty urinating, and an increased heart rate. Promptly seek medical assistance and inform healthcare professionals about the quantity ingested. Treatment involves supportive care and managing symptoms, ensuring the patient's vital signs are monitored until they stabilize. Early intervention is key to minimizing the potential risks associated with this medication overdose.

In the case of a missed dose of Tiotropium 18mcg Capsule, it is recommended to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, consult your healthcare provider for guidance on how to get back on track with your medication routine safely. It is important to maintain consistency with this medication for optimal effectiveness.

To use Tiotropium 18mcg Capsule, inhale the contents of one capsule using an appropriate inhaler device as directed by your healthcare provider, typically once daily, and ensure you follow the instructions for proper inhalation technique to maximize the medication's effectiveness.

Following are the conditions/situations when Tiotropium 18mcg Capsule should not be used:

• Should not be used in individuals with a known allergy to Tiotropium or other similar bronchodilators.
• Not recommended for individuals with narrow-angle glaucoma or urinary retention issues.
• Contraindicated in patients with a history of hypersensitivity reactions to milk proteins, as the capsule contains lactose.
• Should not be used in patients with a history of severe allergic reactions or paradoxical bronchospasm after taking this medication.
• Not suitable for children or adolescents under 18 years of age.
• Avoid using if you have a stomach or intestinal condition that may delay or slow transit of the capsule.

The side effects of Tiotropium 18mcg Capsule may include:

• Dry mouth
• Throat irritation
• Cough or hoarseness
• Nasal congestion
• Urinary tract infection
• Headache
• Dizziness
• Gastrointestinal discomfort

Following are the precautions and warnings for Tiotropium 18mcg Capsule:

• This medication is intended for inhalation only and should never be swallowed. It is crucial to follow the prescribed inhalation technique to ensure proper delivery of the medication to the lungs.
• Tiotropium capsules are not suitable for the relief of sudden asthma attacks or acute bronchospasm. Patients should have a fast-acting rescue inhaler readily available for such emergencies.
• Patients with a history of narrow-angle glaucoma should exercise caution and inform their healthcare provider before using Tiotropium, as it may worsen this condition.
• Individuals with liver or kidney disease should use this medication with caution, as it may require dosage adjustments under medical supervision.
• Tiotropium may cause paradoxical bronchospasm, which leads to sudden breathing difficulties right after using the inhaler. Discontinue use and seek immediate medical attention if this occurs.
• It may cause urinary retention, especially in patients with an enlarged prostate or bladder neck obstruction. Patients should be aware of this risk and report any urinary symptoms to their healthcare provider.
• Patients with a history of cardiovascular disease or arrhythmias should use Tiotropium with caution, as it may potentially increase the risk of cardiovascular events.
• Pregnant and breastfeeding women should consult their healthcare provider before using Tiotropium, as the risks and benefits should be carefully considered.

Following are the drug interactions for Tiotropium 18mcg Capsule:

• Concomitant use with anticholinesterase agents, such as pyridostigmine, can antagonize the effects of Tiotropium, potentially leading to reduced therapeutic efficacy.
• Tiotropium may interact with other anticholinergic medications, including certain antidepressants (e.g., amitriptyline) and antihistamines, resulting in increased side effects like dry mouth, blurred vision, and constipation.
• Use with beta-blockers may lead to additive effects on the cardiovascular system, causing excessive bradycardia or hypotension.
• Tiotropium can interact with certain antifungal medications like ketoconazole, potentially increasing the risk of QT prolongation, a heart rhythm disorder.
• Caution is advised when using Tiotropium with diuretics, as it may enhance the risk of urinary retention, especially in men with prostate enlargement.
• It may interact with certain antibiotics like erythromycin, increasing the risk of cardiac side effects, including QT prolongation.
• Tiotropium can potentially decrease the absorption of certain oral medications, such as ketoconazole, due to its anticholinergic effects on the gastrointestinal tract.

Following are the food interactions for Tiotropium 18mcg Capsule:

• Tiotropium may cause dry mouth, so it is advisable to have sugar-free gum, lozenges, or hard candies to help relieve this side effect.
• Avoid consuming grapefruit or grapefruit juice as it can interfere with the metabolism of Tiotropium, leading to increased drug levels in the body.
• Alcohol consumption should be limited as it may exacerbate side effects like dizziness and blurred vision.
• Caffeine intake should be monitored as it can increase heart rate and blood pressure, which may be a concern for individuals with cardiovascular conditions.
• Dairy products like milk and yogurt can be consumed but in moderation, as they may cause stomach discomfort in some individuals.
• Spicy foods might irritate the respiratory system, so it is best to avoid them while using Tiotropium.
• Well-balanced meals are recommended to ensure proper nutrition and overall health.
• Stay hydrated by drinking plenty of water, especially if experiencing dry mouth as a side effect.

Tiotropium 18mcg Capsules should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. The original packaging should be retained, keeping the medication securely sealed to maintain its integrity. It is crucial to refrain from exposing the capsules to extreme temperatures, such as those found in bathrooms, near heaters, or inside vehicles during hot weather. Always verify the expiration date, and if the capsules are no longer needed or have expired, proper disposal is essential. Avoid flushing them down the toilet or sink; instead, consult a pharmacist or local waste management guidelines for safe disposal methods. Keep the medication securely locked away from children and pets to prevent accidental consumption.

Following are the quick tips for Tiotropium 18mcg Capsule:

• Ensure you are prescribed this medication by a healthcare professional for your specific condition.
• Take the capsule as directed, usually once daily, at the same time each day.
• Swallow the capsule whole with a full glass of water; do not crush, chew, or open it.
• Do not stop taking the medication without consulting your doctor, even if you feel better.
• Store the capsules in a cool, dry place, away from direct sunlight and moisture.
• Inform your doctor about any breathing or lung-related issues you experience while taking this medicine.
• In case of any severe side effects or allergic reactions, seek immediate medical attention.