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Ticagrelor is a type of medication known as a P2Y12 inhibitor. Its primary mechanism of action is to prevent platelet activation and aggregation, which are key steps in the formation of blood clots. It achieves this by specifically and reversibly binding to the P2Y12 receptor on platelets, thereby inhibiting the action of adenosine diphosphate (ADP) on these receptors. ADP is a crucial molecule in the process of platelet activation and aggregation. By blocking the P2Y12 receptor, ticagrelor effectively prevents platelets from clumping together and forming clots, which helps maintain blood flow and reduces the risk of cardiovascular events such as heart attacks or strokes. This mechanism of action is particularly important in the context of preventing thrombotic events in patients with acute coronary syndrome.

Antiplatelet agent

Tablet

The following are the uses of Ticagrelor 60mg Tablet:

• Used for preventing blood clots in people with a history of heart attack or stroke.
• Used to lower the risk of recurrent heart attacks and strokes in specific patients.
• Used to improve blood flow and prevent platelets from sticking together.
• Used to treat Acute Coronary Syndrome (ACS) and reduce the risk of cardiovascular death.
• Used for long-term treatment to maintain heart health and prevent further cardiovascular events.
• Used to manage conditions like Peripheral Artery Disease (PAD) and reduce clotting.
• Used for certain types of chest pain related to reduced blood flow to the heart.

In the case of an overdose of Ticagrelor 60mg Tablets, individuals may experience more intense side effects associated with the medication. Common symptoms of an overdose can include prolonged bleeding, easy bruising, nosebleeds, or red-purple spots on the skin. It is essential to promptly contact a healthcare professional or seek medical advice if an overdose is suspected, as they can provide guidance on the appropriate next steps and necessary treatment. Immediate action is vital to ensure the best possible outcome.

In the case of a missed dose of Ticagrelor 60mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, consult your healthcare provider for guidance, as they may advise you to restart the medication or provide alternative instructions. Always store the medication properly and keep track of your dosing schedule to minimize missed doses.

To take Ticagrelor 60mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your doctor, typically taken twice a day.

Following are the conditions/situations when Ticagrelor 60mg Tablet should not be taken:

• Do not take if you have active bleeding or a history of bleeding disorders.
• Contraindicated in individuals with severe liver impairment.
• Avoid if you have a history of intracranial hemorrhage (bleeding in the brain).
• Do not use if you have a known allergy or hypersensitivity to Ticagrelor or similar medications.
• Should not be taken if you have severe or uncontrolled high blood pressure.
• Not recommended for individuals with severe kidney impairment or end-stage renal disease.
• Avoid in cases of recent major surgery, including dental procedures, as it may increase bleeding risk.
• Do not use if you have a history of conditions that increase the risk of bleeding, such as stomach ulcers or blood clotting disorders.
• Contraindicated in patients with acute coronary syndrome who are at risk of bleeding due to recent major surgery, severe trauma, or other conditions with an active bleeding risk.

The side effects of Ticagrelor 60mg Tablet may include:

• Bleeding (nose, gums, or urine)
• Easy bruising
• Shortness of breath
• Fatigue or weakness
• Dizziness or lightheadedness
• Headache
• Stomach pain or discomfort
• Diarrhea

Following are the precautions and warnings for Ticagrelor 60mg Tablet:

• Do not start or continue the medication if you have a history of severe bleeding or bleeding disorders.
• Ticagrelor may cause prolonged bleeding time, so inform your doctor if you have any planned surgeries or invasive procedures.
• Patients with liver problems should use this medication with caution as it is metabolized by the liver.
• Avoid consuming alcohol while taking Ticagrelor as it may increase the risk of bleeding.
• This medication is not recommended for individuals with severe kidney disease or those on dialysis.
• Patients with a history of lung diseases, such as asthma or chronic obstructive pulmonary disease (COPD), should be closely monitored while on this medication.
• Discontinue use and seek immediate medical attention if you experience any signs of an allergic reaction, such as rash, itching, or difficulty breathing.
• Ticagrelor may interact with other medications, so inform your doctor about all the medicines, supplements, or herbal products you are taking.

Following are the drug interactions for Ticagrelor 60mg Tablet:

• Avoid using with strong CYP3A inhibitors like ketoconazole, as it can significantly increase Ticagrelor's plasma concentrations.
• Concomitant use with CYP3A inducers such as rifampin may reduce the effectiveness of Ticagrelor.
• Combining with aspirin may increase the risk of bleeding, especially with higher doses of aspirin.
• The anticoagulant effect of warfarin may be enhanced, requiring close monitoring of coagulation parameters.
• Using with clopidogrel may increase the risk of bleeding and should be done with caution.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen can further elevate bleeding risk.
• Ticagrelor may interact with certain antihypertensive medications, affecting blood pressure control.

Following are the food interactions to consider with Ticagrelor 60mg Tablet:

• Avoid consuming grapefruit and grapefruit juice as they can interfere with the metabolism of Ticagrelor, leading to increased drug levels in the blood.
• Alcohol consumption should be limited as it may increase the risk of bleeding and affect the effectiveness of the medication.
• Avoid high-fat meals as they can decrease the absorption of Ticagrelor, reducing its therapeutic effect.
• Green leafy vegetables rich in vitamin K (like spinach, kale) may interact and reduce the blood-thinning effect of Ticagrelor.
• Garlic supplements might increase the risk of bleeding when taken with Ticagrelor.
• Limit caffeine intake as it can affect blood pressure and heart rate, especially when starting Ticagrelor treatment.
• Always inform your healthcare provider about your dietary habits to ensure the medication's effectiveness.

Ticagrelor 60mg Tablets should be stored in a cool and dry place, preferably at room temperature (below 25°C) inside a medicine cabinet or a designated storage area. It is crucial to keep the tablets in their original container, tightly sealed to maintain their integrity and protect them from environmental factors. Avoid exposure to direct sunlight, moisture, or extreme temperatures, as these conditions can degrade the medication. When disposing of unused or expired tablets, do not flush them down the toilet or discard them in regular household waste. Instead, follow local guidelines for pharmaceutical waste disposal or consult a pharmacist for guidance on safe and environmentally friendly disposal methods. Ensure that the medication is kept out of children's reach to prevent accidental consumption.

Following are the quick tips for Ticagrelor 60mg Tablet:

• Take the tablet as directed by your doctor, usually twice daily.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• Take it regularly at the same time each day to maintain consistent blood levels.
• Do not stop taking the medication without consulting your doctor.
• Avoid grapefruit and grapefruit juice during treatment.
• Inform your doctor about all medications you are taking to prevent potential interactions.
• Store the medication at room temperature, away from moisture and light.