TOLVON 10MG TAB (LANTANON)

Mianserin Hydrochloride 10MG Tablet primarily exerts its therapeutic effects through its action as an antagonist at certain serotonin receptors, particularly the 5-HT2A and 5-HT2C receptors, and as an antagonist and weak agonist at postsynaptic α1 and α2 adrenergic receptors, respectively. This mechanism is thought to enhance noradrenergic and, to a lesser extent, serotonergic neurotransmission in the central nervous system. By blocking these receptors, Mianserin increases the availability of norepinephrine and serotonin in the synaptic cleft, leading to improved mood and emotional regulation. Additionally, its weak α2-adrenergic receptor agonism may contribute to its overall antidepressant effect by modulating the activity of norepinephrine in the brain.

Tetracyclic antidepressant.

Tablet

The following are the uses of Mianserin Hydrochloride 10MG Tablet:

• Used for treating major depressive disorder, providing mood elevation and relief from symptoms.
• Used for managing severe anxiety disorders, helping to reduce excessive worry and fear.
• Used to treat insomnia, aiding in the improvement of sleep quality and duration.
• Used for managing chronic pain, particularly in conditions like neuropathic pain.
• Used to alleviate hot flashes and night sweats associated with menopause.
• Used for controlling obsessive-compulsive disorder (OCD) symptoms.
• Used in the treatment of eating disorders to regulate appetite and mood.
• Used for certain types of headaches and migraines, offering potential relief.

In the case of an overdose of Mianserin Hydrochloride 10MG Tablets, it is important to recognize the potential symptoms, which may include severe drowsiness, dizziness, and confusion. Overdose can also lead to more serious effects such as difficulty breathing, seizures, and even loss of consciousness. If an overdose is suspected, prompt medical intervention is necessary. Quick action can help mitigate the risks and potential harm associated with this medication. It is crucial to seek emergency medical care and not delay treatment.

In the case of a missed dose of Mianserin Hydrochloride 10MG Tablet, it is generally recommended to take the missed dose as soon as you remember, provided there is a sufficient gap before the next scheduled dose. However, if it is close to the time of your next dose, it is best to skip the missed dose and continue with your regular dosing schedule. Avoid taking a double dose to make up for a missed one, as this may increase the risk of side effects. It is important to maintain a consistent medication routine, but if you frequently miss doses, consult your healthcare provider for guidance on how to improve adherence.

To take Mianserin Hydrochloride 10MG Tablet, swallow the tablet whole with a glass of water, preferably at bedtime or as directed by your healthcare professional, following the prescribed dosage and duration provided by your doctor.

Following are the conditions when Mianserin Hydrochloride 10MG Tablet should not be used:

• Not suitable for individuals with a known hypersensitivity or allergy to Mianserin or any of its inactive ingredients.
• Contraindicated in patients with a history of severe liver or kidney impairment.
• Should not be used in patients with a history of seizures or epilepsy.
• Not recommended for individuals with a history of suicidal thoughts or attempts.
• Contraindicated during the acute recovery phase after a heart attack.
• Should be avoided in individuals with severe low blood pressure.
• Not suitable for patients currently experiencing severe depression or in a state of deep sedation.

The side effects of Mianserin Hydrochloride 10MG Tablet may include:

• Drowsiness or fatigue
• Dry mouth
• Blurred vision
• Constipation
• Increased appetite and weight gain
• Dizziness or lightheadedness
• Skin rash or itching
• Difficulty urinating

Following are the precautions and warnings for Mianserin Hydrochloride 10MG Tablet:

• This medication should be used with caution in patients with a history of seizures or epilepsy, as it may lower the seizure threshold.
• Mianserin can cause orthostatic hypotension, so patients should be advised to rise slowly from a sitting or lying position to prevent dizziness or fainting.
• It may cause anticholinergic effects, leading to blurred vision and difficulty urinating, especially in elderly patients.
• Patients with cardiovascular disease should be monitored closely, as Mianserin can affect heart rhythm and blood pressure.
• Liver function tests are recommended during long-term treatment to detect any potential liver-related issues.
• The use of Mianserin in patients with severe depression or suicidal tendencies should be closely monitored, and any worsening of symptoms should be reported immediately.
• It may cause photosensitivity, so patients should minimize sun exposure and use protective measures when outdoors.

Following are the drug interactions for Mianserin Hydrochloride 10MG Tablet:

• Alcohol and CNS depressants (e.g., benzodiazepines, opioids) may enhance the sedative effects, leading to increased drowsiness and impaired coordination.
• Mianserin can interact with other antidepressants like SSRIs, SNRIs, and MAOIs, potentially causing serotonin syndrome, a serious condition with symptoms like agitation, confusion, and rapid heart rate.
• The effect of anticoagulants like warfarin may be altered, requiring close monitoring of coagulation parameters.
• Medications metabolized by CYP2D6 and CYP3A4 enzymes can have their levels affected by Mianserin, including certain antipsychotics and beta-blockers.
• Caution with antihypertensive drugs as Mianserin may cause postural hypotension, potentially requiring dosage adjustments.
• The effectiveness of anticonvulsants may be reduced, and seizure threshold may be lowered.
• Mianserin may increase the concentration of some antidiabetic drugs, potentially affecting blood glucose levels.

Following are the food interactions to consider with Mianserin Hydrochloride 10MG Tablet:

• Alcohol consumption should be avoided as it may increase the sedative effects of Mianserin, leading to enhanced drowsiness and dizziness.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of Mianserin, potentially increasing its levels in the blood and the risk of side effects.
• High-fat meals may slightly delay the absorption of Mianserin but are generally not expected to significantly impact its effectiveness.
• Caffeine intake should be monitored as Mianserin may enhance its effects, potentially causing increased nervousness and rapid heartbeat.
• Foods rich in tyramine, like aged cheeses and cured meats, should be avoided as Mianserin can interact with tyramine, leading to a potentially dangerous spike in blood pressure.
• Salt and sodium-rich foods should be limited as Mianserin may cause sodium retention, which can be problematic for individuals with heart or kidney issues.
• It's advisable to maintain a balanced diet and stay well-hydrated to support overall health and the medication's effectiveness.
• Always consult your healthcare provider for personalized advice regarding specific food interactions and dietary recommendations.

Mianserin Hydrochloride 10MG Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area, ensuring they are kept out of reach of children and pets. Maintain a consistent room temperature, avoiding exposure to direct sunlight, excessive heat, or moisture, as these conditions can degrade the medication. It is crucial not to remove the tablets from their original packaging unless you are about to take a dose. Once the medication is no longer needed or has passed its expiration date, proper disposal is essential. Do not flush the tablets or throw them into the trash in their original containers. Contact your pharmacist or healthcare provider for guidance on safe disposal methods to protect the environment and prevent accidental ingestion by others.

Following are the quick tips for Mianserin Hydrochloride 10MG Tablet:

• Start with the lowest effective dose and gradually increase as needed under medical supervision.
• Swallow the tablet whole with a full glass of water; do not crush or chew.
• Take the tablet at the same time each day to maintain consistent blood levels.
• Avoid alcohol consumption as it may increase side effects.
• Inform your doctor about all medications you are taking to prevent potential interactions.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.
• Do not share your medication with others, even if they have similar symptoms.
• Consult your doctor if you experience any unusual or persistent side effects.