Tone-Up (500mcg) 20 Capsules

Trimetazidine HCl acts by inhibiting the beta-oxidation of fatty acids in cardiac cells, shifting cellular metabolism from fatty acid oxidation to glucose oxidation. This mechanism is achieved by selectively blocking the enzyme 3-ketoacyl CoA thiolase, which is involved in fatty acid metabolism. By promoting glucose oxidation, trimetazidine helps maintain energy production in the heart, particularly during periods of ischemia or hypoxia. It improves cardiac efficiency by enhancing the utilization of glucose, which requires less oxygen compared to fatty acid metabolism, thereby optimizing energy utilization and potentially reducing myocardial oxygen demand.

Angina treatment

Capsule

The following are the uses of Trimetazidine Hcl 500mcg Capsule:

• Used for treating Angina (chest pain)
• Used to improve heart function in patients with heart failure
• Used to manage symptoms of Myocardial Infarction (heart attack)
• Used to reduce episodes of angina attacks
• Used to enhance exercise capacity in patients with coronary artery disease
• Used to treat vertigo and tinnitus associated with Meniere's disease
• Used to manage metabolic disorders in the heart and brain
• Used as an adjunct therapy to improve outcomes in cardiovascular conditions

In the case of an overdose of Trimetazidine Hcl 500mcg capsules, symptoms may include dizziness, headache, and gastrointestinal issues. The severity of the overdose can vary depending on the amount ingested. If an overdose is suspected, it is recommended to seek medical advice promptly. Quick action can help manage symptoms and prevent potential complications, ensuring the best possible outcome for the patient. It is crucial to act swiftly in such situations.

In the case of a missed dose of Trimetazidine Hcl 500mcg Capsule, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication regimen. Always consult your healthcare provider if you have any concerns or questions regarding missed doses.

To take Trimetazidine Hcl 500mcg Capsule, swallow the capsule whole with a glass of water, following the prescribed dosage instructions provided by your healthcare professional, typically once or twice daily, without crushing or chewing the capsule.

Here are the conditions and situations when Trimetazidine Hcl 500mcg Capsule should not be taken:

• Should not be used in patients with a known allergy or hypersensitivity to Trimetazidine or any of its excipients.
• Contraindicated in patients with severe liver impairment or active liver disease.
• Not recommended for individuals with severe kidney impairment or end-stage renal disease.
• Should be avoided in patients with a history of Parkinson's disease.
• Not suitable for patients with severe respiratory failure or unstable hemodynamics.
• Should not be used during breastfeeding as it may pass into breast milk.
• Contraindicated in patients with a history of ischemic heart disease or those who have recently had a heart attack.

The side effects of Trimetazidine Hcl 500mcg Capsule may include:

• Nausea and vomiting
• Abdominal pain
• Diarrhea
• Dry mouth
• Dizziness or lightheadedness
• Headache
• Skin rashes or itching
• Fatigue or weakness

Following are the precautions and warnings for Trimetazidine Hcl 500mcg Capsule:

• This medication should be used with caution in patients with severe kidney or liver disease, as dosage adjustments may be necessary.
• Patients with a history of Parkinson's disease should use this medication with caution, as it may worsen symptoms.
• Trimetazidine can cause dizziness and fatigue; patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Not recommended for children and adolescents under 18 years of age due to limited data on safety and efficacy.
• Elderly patients may be more susceptible to side effects, and dosage adjustments might be required.
• Patients with a history of heart problems, such as heart block or heart failure, should be closely monitored while taking this medication.
• If you have a known allergy to Trimetazidine or any other ingredients in the capsule, do not use it.

Following are the drug interactions for Trimetazidine Hcl 500mcg Capsule:

• Trimetazidine may interact with beta-blockers, enhancing their effects and potentially causing bradycardia. Close monitoring is advised.
• Concomitant use with calcium channel blockers can lead to hypotension and increased risk of adverse cardiac events.
• It may reduce the effectiveness of antiarrhythmic drugs, requiring careful monitoring of cardiac function.
• The risk of bleeding may be elevated when combined with anticoagulants or antiplatelet drugs.
• Trimetazidine can affect the metabolism of certain medications, including statins, potentially increasing their side effects.
• Patients taking diabetes medications should be monitored for changes in blood glucose levels as Trimetazidine may influence glucose metabolism.
• Combining with other metabolic modulators may increase the risk of lactic acidosis.

Following are the food interactions for Trimetazidine Hcl 500mcg Capsule:

• Avoid grapefruit and grapefruit juice as they can interfere with the metabolism of the drug, leading to increased levels of Trimetazidine in the body and potentially causing adverse effects.
• Alcohol consumption should be limited as it can enhance the sedative effects of Trimetazidine, increasing the risk of dizziness and impaired coordination.
• Avoid high-fat meals as they may delay the absorption of Trimetazidine, affecting its onset of action.
• Caffeine-rich foods and beverages should be consumed in moderation as they can interact with Trimetazidine, potentially causing increased heart rate and blood pressure fluctuations.
• Avoid excessive salt intake, as Trimetazidine is often used in conditions where salt restriction is advised, and high salt consumption may counteract the therapeutic effects.
• Patients with diabetes should carefully monitor their sugar intake, as Trimetazidine can affect glucose metabolism and require adjustments in diabetes management.
• Ensure a balanced diet rich in whole grains, lean proteins, and fresh produce to support overall health while taking Trimetazidine.
• Always follow dietary recommendations provided by your healthcare professional, especially if you have specific dietary restrictions or medical conditions.

Trimetazidine Hcl 500mcg capsules should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. Keep the capsules in their original container, tightly sealed, to maintain their integrity and prevent contamination. Avoid exposing the medication to extreme temperatures by not storing it in the bathroom or near heat sources. Always check the expiration date, and for proper disposal of unused or expired capsules, consult a pharmacist or healthcare professional for guidance. Keep the medication away from children to prevent accidental consumption.

Following are the quick tips for Trimetazidine Hcl 500mcg Capsule:

• Consult a doctor for a personalized prescription and dosage instructions.
• Take the capsule as directed by your physician, typically with a glass of water.
• Ensure you complete the full course as prescribed.
• Maintain a consistent daily routine for taking the medication.
• Avoid crushing or chewing the capsule; swallow it whole.
• Store the medication in a cool, dry place, away from direct sunlight.
• Inform your doctor about any other medications you're taking to prevent potential interactions.
• Regularly monitor your health and report any unusual symptoms to your healthcare provider.