Tofen (1mg/5ml) 100ml Syrup

Ketoprofen syrup/suspension, a nonsteroidal anti-inflammatory drug (NSAID), exerts its therapeutic effects through the inhibition of cyclooxygenase (COX) enzymes, primarily COX-1 and COX-2. By blocking these enzymes, ketoprofen reduces the production of prostaglandins, which are key mediators of inflammation and pain. This mechanism of action helps alleviate inflammation, lower fever, and provide analgesia by decreasing the synthesis of prostaglandin precursors and subsequent inflammatory responses. The inhibition of COX enzymes is central to ketoprofen's ability to manage pain and inflammation associated with various conditions, making it a commonly prescribed medication for these purposes.

Ketoprofen

NSAID (Non-steroidal anti-inflammatory drug)

Suspension

The following are the uses of Ketoprofen Syrup/Suspension:

• Used for reducing pain and inflammation associated with acute injuries, such as sprains, strains, and minor fractures.
• Used for managing post-operative pain and swelling following surgical procedures.
• Used for treating acute gout attacks to alleviate pain and inflammation.
• Used for relieving pain and discomfort in conditions like rheumatoid arthritis and osteoarthritis.
• Used for reducing fever and providing analgesia in various inflammatory conditions.
• Used for easing dental pain and inflammation after oral surgeries or procedures.
• Used for treating migraine headaches to reduce pain and associated symptoms.

In the case of an overdose of Ketoprofen Syrup/Suspension, individuals may experience severe gastrointestinal issues, such as stomach pain, nausea, and vomiting. Excessive doses can lead to kidney damage and, in rare cases, liver failure. Prompt medical intervention is vital, and healthcare professionals should be contacted immediately. Managing an overdose may involve inducing vomiting or administering activated charcoal to prevent further absorption of the medication.

In the case of a missed dose of Ketoprofen Syrup/Suspension, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication regimen. It is essential to maintain consistency with your dosing schedule to ensure the medication's effectiveness.

To administer Ketoprofen Syrup/Suspension, shake the bottle well, measure the prescribed dose using a measuring device like a marked measuring spoon or oral syringe, and take it orally, preferably with food, as directed by your healthcare professional, ensuring you follow the recommended dosage for your age and condition.

Here are the conditions or situations when Ketoprofen Syrup/Suspension should not be used:

• Must not be used in individuals with a known allergy or hypersensitivity to Ketoprofen or other non-steroidal anti-inflammatory drugs (NSAIDs).
• Contraindicated in patients with active or recent gastrointestinal bleeding or perforation.
• Not suitable for individuals who have experienced asthma, hives, or allergic-type reactions after taking aspirin or other NSAIDs.
• Should not be used in patients with severe heart failure or severe kidney disease.
• Contraindicated during the last trimester of pregnancy due to potential fetal harm.
• Avoid using in patients with a history of peptic ulcers or gastrointestinal bleeding disorders.
• Not recommended for individuals with bleeding disorders or those taking blood-thinning medications.
• Must be used with caution and under medical supervision in patients with a history of heart disease or high blood pressure.
• Contraindicated in patients with aspirin-sensitive asthma.
• Should not be used in patients with severe dehydration or those who are unable to maintain adequate fluid intake.

The side effects of Ketoprofen Syrup/Suspension may include:

• Stomach pain or discomfort
• Nausea and vomiting
• Diarrhea
• Dizziness or vertigo
• Headache
• Drowsiness or fatigue
• Skin rash or itching
• Increased blood pressure

Following are the precautions and warnings for Ketoprofen Syrup/Suspension:

• This medication should not be used in individuals with a known hypersensitivity or allergy to Ketoprofen or any other NSAIDs (Non-Steroidal Anti-Inflammatory Drugs).
• Patients with a history of gastrointestinal bleeding, ulcers, or other stomach disorders should use this medication with caution, as it may aggravate these conditions.
• Ketoprofen may increase the risk of cardiovascular events such as heart attack or stroke, especially with long-term use. Patients with cardiovascular disease or risk factors should be closely monitored.
• It is important to avoid excessive use of this medication, as it may cause liver damage. Regular monitoring of liver function is recommended during prolonged treatment.
• Elderly patients may be more susceptible to the side effects of Ketoprofen, particularly gastrointestinal bleeding and kidney problems. Dosage adjustments may be necessary.
• Not recommended for use in children below 16 years of age unless prescribed by a healthcare professional.
• Pregnant and breastfeeding women should consult their doctor before taking this medication, as it may have potential risks to the fetus and infant.
• Always read the patient information leaflet provided with the medication and consult a healthcare professional if you have any concerns or questions.

Following are the drug interactions for Ketoprofen Syrup/Suspension:

• Aspirin and other NSAIDs (e.g., ibuprofen, naproxen) may increase the risk of gastrointestinal bleeding and ulcers when taken concurrently with Ketoprofen.
• Ketoprofen can reduce the effectiveness of diuretics and ACE inhibitors, potentially leading to decreased blood pressure control.
• Lithium levels may be increased when used with Ketoprofen, requiring close monitoring.
• Corticosteroids can increase the risk of gastrointestinal bleeding when combined with Ketoprofen.
• Anticoagulants like warfarin may have their effects enhanced, increasing the risk of bleeding.
• Methotrexate toxicity may be increased when taken with Ketoprofen.
• The use of Ketoprofen with other nephrotoxic drugs may increase the risk of kidney damage.

Following are the food interactions to consider with Ketoprofen Syrup/Suspension:

• Avoid excessive alcohol consumption while taking this medication as it can increase the risk of gastrointestinal bleeding and liver toxicity.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Ketoprofen, potentially increasing its levels in the body and the risk of side effects.
• Dairy products like milk and yogurt can help reduce stomach irritation caused by Ketoprofen.
• Foods rich in vitamin C, such as citrus fruits and broccoli, may enhance the absorption of Ketoprofen.
• Avoid high-fat meals as they can delay the absorption of Ketoprofen, potentially affecting its onset of action.
• Spicy foods should be consumed in moderation as they can irritate the stomach, especially when taking anti-inflammatory medications.
• Stay well-hydrated and maintain a balanced diet to support overall health while using Ketoprofen.
• Consult your healthcare provider for specific dietary recommendations based on your medical condition and medication regimen.

Ketoprofen Syrup/Suspension should be stored with caution, preferably in a cool and dry place at room temperature, ensuring it is protected from light and moisture. The original container should be tightly sealed to maintain its integrity and prevent contamination. It is crucial to avoid exposing the medication to extreme temperatures, so keep it away from heat sources and never store it in the bathroom. Regularly check the expiration date, and if the medication is no longer needed or has expired, proper disposal is essential. Do not dispose of it via household waste or sewage systems; instead, follow local guidelines or consult a healthcare professional for safe disposal methods. Always keep medications secure and out of children's reach to prevent accidental consumption.

Following are the quick tips for Ketoprofen Syrup/Suspension:

• Administer the syrup as directed by your doctor or pharmacist for best pain relief.
• Measure the dose accurately using the measuring cup provided.
• Ensure the syrup is stored at room temperature, away from direct sunlight or moisture.
• Take the medication with food to minimize stomach irritation.
• Avoid driving or operating heavy machinery until you know how the medication affects you.
• Do not exceed the prescribed dose, and contact your doctor if your symptoms worsen.
• Inform your healthcare provider about any other medications you are taking to prevent potential interactions.