TRANDATE 200MG IMP

Labetalol HCl 200MG Tablet works by a dual mechanism of action. It blocks both alpha• and beta-adrenergic receptors in the body. By blocking alpha receptors, labetalol reduces peripheral vascular resistance, causing vasodilation, which helps lower blood pressure. Simultaneously, its beta-blocking activity decreases heart rate and cardiac output, further contributing to blood pressure reduction. This dual action makes labetalol effective in treating hypertension as it not only relaxes blood vessels but also reduces the workload on the heart.

Labetalol HCl 200MG

Beta-blocker.

Tablet

The following are the uses of Labetalol HCl 200MG Tablet:

• Used for treating high blood pressure, reducing the risk of stroke, heart attack, and kidney problems.
• Used to lower blood pressure in patients with hypertension, helping to prevent serious complications.
• Used in the management of angina, a condition causing chest pain, by reducing the frequency and severity of attacks.
• Used for short-term control of blood pressure in patients with severe hypertension who require immediate reduction.
• Used to improve survival rates and reduce hospital stays for patients with heart failure, by improving heart function.
• Used for treating patients with a recent heart attack to reduce the risk of further complications and improve recovery.
• Used for long-term maintenance of blood pressure control, often in combination with other medications.

In the case of an overdose of Labetalol HCl 200MG Tablets, individuals may experience a significant drop in blood pressure, leading to symptoms such as dizziness, lightheadedness, and fainting. Other potential effects include bradycardia (slow heart rate), hypotension, and in severe cases, shock. Prompt medical intervention is vital, as healthcare professionals can administer supportive care, monitor vital signs, and provide appropriate treatment to manage the consequences of an overdose.

In the case of a missed dose of Labetalol HCl 200MG Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely adjust your medication regimen.

To take Labetalol HCl 200MG Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the exact dosage instructions provided by your healthcare professional.

Here are the conditions and situations when Labetalol HCl 200MG Tablet should not be taken:

• Must not be used in patients with known severe allergies to Labetalol or any other beta-blockers.
• Not suitable for patients with severe heart failure or those experiencing low heart rate (bradycardia).
• Should be avoided in patients with severe liver disease or reduced liver function.
• Contraindicated in patients with a history of asthma or chronic obstructive pulmonary disease (COPD).
• Not recommended for patients with peripheral vascular disease, as it may worsen symptoms.
• Should not be used in patients with a history of cardiogenic shock.
• Avoid use during severe forms of Raynaud's syndrome.
• Not suitable for patients with metabolic acidosis.
• Must be used with caution and avoided if possible in patients with diabetes, as it may mask the symptoms of low blood sugar.

The side effects of Labetalol HCl 200MG Tablet may include:

• Fatigue and weakness
• Dizziness or lightheadedness
• Gastrointestinal issues like nausea, vomiting, or diarrhea
• Dry mouth
• Difficulty breathing or shortness of breath
• Irregular heartbeat
• Cold hands and feet
• Sexual dysfunction

Following are the precautions and warnings for Labetalol HCl 200MG Tablet:

• Avoid using this medication if you have a known allergy to Labetalol or any other beta-blockers.
• Patients with a history of respiratory diseases like asthma or chronic obstructive pulmonary disease (COPD) should use with caution, as it may worsen these conditions.
• Labetalol may cause dizziness or lightheadedness; ensure you are aware of how you react before driving or operating machinery.
• Inform your doctor if you have a history of heart problems, liver disease, or diabetes, as this medication may require careful monitoring.
• Do not abruptly stop taking Labetalol; gradual reduction is advised to prevent potential adverse effects.
• Elderly patients may be more sensitive to the effects of this medication and should be monitored closely.
• Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as Labetalol may have potential risks during these periods.

Following are the drug interactions for Labetalol HCl 200MG Tablet:

• Concurrent use with other antihypertensive medications like ACE inhibitors, diuretics, or calcium channel blockers may result in additive blood pressure-lowering effects.
• Labetalol can increase the levels of certain drugs metabolized by the liver, such as warfarin, phenytoin, and lidocaine, requiring close monitoring.
• The use of Labetalol with insulin or oral hypoglycemic agents may mask the signs of hypoglycemia, making blood glucose monitoring essential.
• Non-steroidal anti-inflammatory drugs (NSAIDs) may reduce the antihypertensive effects of Labetalol.
• Beta-blockers like Labetalol can decrease bronchodilation effects of beta-agonists, potentially affecting patients with asthma or COPD.
• It may interact with certain calcium channel blockers, leading to decreased heart rate and contractility.
• Labetalol can enhance the effects of other beta-blockers, increasing the risk of bradycardia and hypotension.
• Close monitoring is required when combining Labetalol with digoxin, as it may increase the risk of bradycardia and heart block.

Following are the food interactions for Labetalol HCl 200MG Tablet:

• Grapefruit and grapefruit juice consumption should be avoided as they can alter the absorption and metabolism of Labetalol, potentially leading to increased blood levels and a higher risk of side effects.
• Alcohol intake should be minimized or avoided as it may increase the sedative effects and decrease blood pressure further, leading to lightheadedness and dizziness.
• Caffeine-rich foods and beverages like coffee, tea, and energy drinks should be consumed in moderation as they can counteract the blood pressure-lowering effect of Labetalol.
• High-sodium foods should be limited as they can reduce the effectiveness of Labetalol in controlling blood pressure.
• A balanced diet rich in fruits, vegetables, whole grains, and lean proteins can enhance the overall cardiovascular benefits of Labetalol.
• Avoid consuming high-fat meals as they may affect the absorption and distribution of Labetalol in the body.
• Always take the medication as directed by your healthcare provider, and consult them regarding any specific dietary adjustments necessary while taking Labetalol.

Labetalol HCl 200MG Tablets should be stored in a cool, controlled environment, ideally between 68°F and 77°F (20°C and 25°C). It is crucial to keep the tablets in their original container, tightly sealed, to maintain their integrity and protect them from moisture and light. Avoid exposing the medication to direct sunlight or high temperatures, as this can degrade its quality. When disposing of unused or expired tablets, do not throw them in the trash or flush them down the toilet. Instead, follow local guidelines for pharmaceutical waste disposal or consult your pharmacist for environmentally friendly disposal methods. Ensure that the medication is kept secure and out of the reach of children and pets to prevent accidental consumption. Proper storage and disposal practices are essential to maintain the effectiveness of the medication and to protect the environment.

Following are the quick tips for Labetalol HCl 200MG Tablet:

• Consult your doctor before starting the medication for personalized advice.
• Take the tablet as directed by your doctor, typically 2-3 times a day.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• Maintain a consistent schedule for taking the medication as prescribed.
• Inform your doctor if you have existing medical conditions or are taking other medications.
• Do not stop taking the medication abruptly without medical advice.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.