Trevia R2 (5/100mg) 14 Tablets

Sitagliptin and Ertugliflozin are two different medications combined in a single tablet to treat type 2 diabetes. Sitagliptin works by inhibiting the enzyme dipeptidyl peptidase-4 (DPP-4), which leads to an increase in the levels of incretin hormones, such as GLP-1 (glucagon-like peptide-1). This increase in incretin hormones stimulates insulin production and reduces the release of glucagon, resulting in lower blood glucose levels. On the other hand, Ertugliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor. It blocks the reabsorption of glucose in the kidneys, promoting the removal of glucose through urine, and thereby lowering blood sugar levels. Together, these mechanisms help improve glycemic control in individuals with type 2 diabetes.

DPP-4 inhibitor, SGLT2 inhibitor.

Tablet

The following are the uses of Sitagliptin 100mg, Ertugliflozin 5mg Tablet:

• Used for managing type 2 diabetes by controlling blood sugar levels
• Used to improve glycemic control when other medications have not been effective
• Used to help reduce the risk of cardiovascular events in diabetic patients
• Used to promote weight loss and improve insulin sensitivity
• Used for reducing A1C levels, a measure of long-term blood sugar control
• Used to treat diabetic nephropathy, protecting kidney function
• Used for managing diabetic ketoacidosis in hospitalized patients
• Used to delay the progression of diabetes-related complications

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• The recommended dose for treatment of type 2 diabetes is Ertugliflozin 5mg and Sitagliptin 100mg
• The dose should be adjusted based on the response and tolerability of the drug under a physician's supervision

In the case of an overdose of Sitagliptin 100mg and Ertugliflozin 5mg Tablet, symptoms may include severe nausea, vomiting, diarrhea, and dizziness. It is important to seek medical advice promptly if you suspect an overdose. The healthcare provider may recommend supportive measures such as monitoring vital signs, administering intravenous fluids, and providing appropriate medical treatment to manage any severe symptoms that occur. Quick action can help mitigate the potential risks associated with this medication overdose.

In the case of a missed dose of Sitagliptin 100mg, it is generally recommended to take the missed dose as soon as you remember, unless it is close to the time for your next scheduled dose. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. For Ertugliflozin 5mg Tablet, if you miss a dose, take it as soon as you remember, but if it's closer to the time of your next dose, skip the missed dose and continue with your regular dosing regimen. It is important not to double the dose to make up for a missed one.

To take Sitagliptin 100mg and Ertugliflozin 5mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional, typically taken once daily with or without food as directed.

Following are the conditions or situations when Sitagliptin 100mg, Ertugliflozin 5mg Tablet should not be taken:

• Should not be used in individuals with a known allergy to Sitagliptin, Ertugliflozin, or any other similar medications.
• Contraindicated in patients with type 1 diabetes mellitus or diabetic ketoacidosis.
• Not suitable for individuals with severe kidney disease or end-stage renal disease.
• Should not be used if you have a history of a severe allergic reaction to any DPP-4 inhibitor or SGLT2 inhibitor.
• Avoid if you have a condition called 'diabetic ketoacidosis' or are at risk of developing it.
• Not recommended for individuals with a history of a serious allergic reaction to Sitagliptin or Ertugliflozin.
• Should not be used in patients with severe liver disease or active liver disease.
• Not suitable for individuals with a recent history of pancreatitis.

The side effects of Sitagliptin 100mg, Ertugliflozin 5mg Tablet may include:

• Nausea and vomiting
• Stomach pain or discomfort
• Diarrhea
• Fatigue and weakness
• Dizziness or lightheadedness
• Skin rash or itching
• Increased urination
• Joint pain

Following are the precautions and warnings for Sitagliptin 100mg, Ertugliflozin 5mg Tablet:

• This medication is not recommended for individuals with a known allergy to Sitagliptin, Ertugliflozin, or any of the tablet's inactive ingredients.
• Patients with kidney disease or a history of pancreatitis should exercise caution and inform their healthcare provider before taking this medication.
• It may cause a rare but serious condition called ketoacidosis, which requires immediate medical attention. Symptoms include nausea, vomiting, stomach pain, tiredness, and trouble breathing.
• Monitor blood sugar levels regularly as this medication can cause hypoglycemia, especially when used with other diabetes medications.
• Patients with type 1 diabetes should not use this medication as it is not effective for treating this condition.
• Elderly patients may be more susceptible to the side effects of this medication, particularly on kidney function.
• Inform your doctor if you have a history of liver problems or are taking other medications, as dosage adjustments might be necessary.

Following are the drug interactions for Sitagliptin 100mg, Ertugliflozin 5mg Tablet:

• Concomitant use with sulfonylureas or insulin may increase the risk of hypoglycemia, so regular monitoring of blood glucose is necessary.
• Digoxin levels may be increased, so close monitoring of digoxin concentrations is recommended.
• The use of SGLT2 inhibitors like ertugliflozin with loop diuretics (e.g., furosemide) or thiazide diuretics may increase the risk of dehydration and hypotension.
• Ertugliflozin can decrease the efficacy of oral contraceptives, so additional contraceptive methods are advised.
• May interact with medications that affect kidney function, such as nonsteroidal anti-inflammatory drugs (NSAIDs) or ACE inhibitors.
• Caution with angiotensin receptor blockers (ARBs) or angiotensin-converting enzyme (ACE) inhibitors, as they may increase the risk of angioedema.
• Sitagliptin may increase the risk of metformin-associated lactic acidosis; monitor for signs and symptoms.

Following are the food interactions for Sitagliptin 100mg and Ertugliflozin 5mg Tablet:

• Alcohol consumption should be limited as it can increase the risk of hypoglycemia, especially when combined with other antidiabetic medications.
• Grapefruit and grapefruit juice should be avoided as they may alter the blood levels of Sitagliptin, potentially affecting its efficacy.
• Avoid high-potassium foods like bananas, oranges, and spinach in excess, as Ertugliflozin can increase potassium levels.
• Salt substitutes containing potassium should be used with caution, as they may also increase potassium levels.
• Monitor your blood glucose levels when consuming sugary foods or beverages, as the medication may not provide sufficient control over blood sugar spikes.
• A balanced diet is essential; consult a dietician for personalized advice.
• Avoid excessive alcohol intake, as it can interact with Ertugliflozin and affect kidney function.

Sitagliptin 100mg, Ertugliflozin 5mg tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. Keep the tablets in their original packaging, tightly sealed, to maintain their integrity. It is crucial not to expose the medication to extreme temperatures or humidity, so avoid storage in bathrooms or near heat sources. When disposing of unused or expired tablets, do not flush them or throw them into the trash. Instead, consult a pharmacist or local waste management authority for safe disposal guidelines to prevent environmental contamination. Always keep medications securely stored away from children to prevent accidental consumption.

Following are the quick tips for Sitagliptin 100mg and Ertugliflozin 5mg Tablet:

• Always take the medication as directed by your doctor; do not adjust the dosage without consulting them.
• Ensure you swallow the tablet whole with a full glass of water; do not crush or chew it.
• Take your dose at the same time each day to maintain consistent blood levels.
• You can take the tablet with or without food, but be consistent with your choice.
• If you miss a dose, take it as soon as you remember, unless it's close to your next dose; do not double dose.
• Keep the medication in a cool, dry place, away from direct sunlight and moisture.
• Inform your doctor about all the medications you are taking to avoid potential drug interactions.
• Regularly monitor your blood sugar levels as advised by your healthcare provider.

When taking Ertugliflozin 5mg and Sitagliptin 100mg, it is important to undergo lab tests to ensure your safety and adjust your dosage accordingly. Firstly, it is crucial to regularly monitor your blood sugar levels to ensure they are within the desired range. This should be done before starting the medication and periodically throughout your treatment to maintain optimal blood sugar control. Secondly, as Ertugliflozin can cause mild to moderate decreases in kidney function, it is important to perform periodic tests that assess kidney function, such as serum creatinine and estimated glomerular filtration rate (eGFR). This ensures that the medication is not adversely affecting the kidneys and that the dosage can be adjusted accordingly. It is also advisable to keep track of your weight as antidiabetic drugs may cause weight loss or gain. Your healthcare provider may recommend adjustments to your treatment plan based on changes in your weight. Additionally, a lipid profile test should be performed to monitor any changes in cholesterol and triglyceride levels. This is important as Ertugliflozin can modestly alter lipid levels, and periodic monitoring ensures that your lipid levels remain within the desired range and that any adjustments to your lipid-lowering therapy can be made if necessary. You should also monitor for any gastrointestinal symptoms as nausea, vomiting, or diarrhea may occur with Sitagliptin. If these side effects persist or worsen, further investigations or adjustments to your treatment plan may be required. Lastly, educate yourself about the signs and symptoms of low blood sugar (hypoglycemia) and regularly check your blood sugar levels if you are taking anti-hyperglycemic drugs, including insulin. Undergoing these lab tests helps to ensure your safety and effectiveness when taking Ertugliflozin 5mg and Sitagliptin 100mg.