Trimex (120mg) 30 Capsules

Trimetazidine HCl 120mg Capsule primarily acts by inhibiting the beta-oxidation of fatty acids in cardiac cells. Its mechanism of action involves shifting the energy metabolism of the heart from fatty acid utilization to glucose utilization. By blocking long-chain 3-ketoacyl-CoA thiolase, an enzyme involved in fatty acid oxidation, trimetazidine reduces the production of acetyl-CoA from fatty acids. This shift in energy substrate preference helps protect myocardial cells during ischemic conditions. Trimetazidine enhances glucose oxidation, which is more energy-efficient and requires less oxygen compared to fatty acid metabolism. As a result, it improves the efficiency of myocardial energy production, reduces oxygen demand, and helps maintain cellular energy balance, thereby providing cardioprotective effects, particularly in situations where the heart's blood and oxygen supply is compromised.

Antianginal (anti-ischemic) agent.

Capsule

The following are the uses of Trimetazidine Hcl 120mg Capsule:

• Trimetazidine HCl 120mg Capsule is used as an anti-anginal medication to treat chest pain (angina) in patients with coronary artery disease.
• It works by improving the efficiency of the heart muscle, increasing its ability to use oxygen and reducing the risk of heart-related symptoms.
• The medication helps in enhancing myocardial (heart muscle) metabolism and improving energy utilization, particularly during periods of stress or physical exertion.
• It is commonly used in combination with other medications to manage angina, especially in patients who have not responded to other treatments.
• Trimetazidine may also be used in the management of certain conditions related to the heart's electrical activity and ischemic events.
• In some cases, it is prescribed for the treatment of vertigo or dizziness related to poor blood flow to the brain.
• Trimetazidine helps to reduce the frequency and severity of angina attacks, allowing patients to engage in daily activities with less discomfort.

In the case of an overdose of Trimetazidine Hcl 120mg Capsules, it is important to act promptly. Symptoms may include severe dizziness, fainting, or an irregular heartbeat. If you or someone else has taken an excessive amount, seek medical help immediately. Quick action can prevent potential health risks and ensure appropriate treatment. Contact a healthcare professional or go to the nearest emergency room for guidance and support.

In the case of a missed dose of Trimetazidine HCL 120mg Capsule, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Avoid taking a double dose to make up for a missed one, as this may increase the risk of side effects. It is advisable to set a reminder or use a pill organizer to help you remember your medication schedule and minimize the chances of missing a dose.

To take Trimetazidine HCL 120mg Capsule, swallow the capsule whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Here are the conditions or situations when Trimetazidine Hcl 120mg Capsule should not be taken:

• Should not be used in patients with a known allergy or hypersensitivity to Trimetazidine or any of its components.
• Contraindicated in patients with severe liver impairment or severe kidney disease.
• Not recommended for children and adolescents under 18 years of age due to insufficient data on safety and efficacy.
• Should not be used during pregnancy, especially in the first trimester, unless the potential benefits outweigh the risks.
• Not suitable for breastfeeding mothers, as it may pass into breast milk and harm the nursing infant.
• Should be avoided in patients with a history of Parkinson's disease or other movement disorders.
• Not recommended for patients with a history of depression or other psychiatric disorders.
• Contraindicated in patients with severe heart failure or unstable angina.

The side effects of Trimetazidine Hcl 120mg Capsule may include:

• Fatigue and weakness
• Nausea and vomiting
• Dizziness or lightheadedness
• Headache
• Sleep disturbances (insomnia)
• Skin rashes or itching
• Gastrointestinal issues (diarrhea or constipation)
• Muscle pain or joint stiffness

Following are the precautions and warnings for Trimetazidine Hcl 120mg Capsule:

• Not recommended for individuals with a history of severe liver or kidney disease, as it may worsen their condition.
• Elderly patients should use with caution due to potential increased risk of adverse effects.
• Patients with diabetes should monitor their blood sugar levels regularly as this medication can affect glucose metabolism.
• Avoid driving or operating heavy machinery if you experience dizziness or fatigue while on this medication.
• Inform your doctor if you have a history of heart problems, as this medication may impact cardiac function.
• This medication should be used with caution in patients with a history of Parkinson's disease.
• Do not abruptly stop taking Trimetazidine Hcl without consulting your doctor, as it may lead to withdrawal symptoms.
• Always inform your healthcare provider about any other medications you are taking to avoid potential drug interactions.

Following are the drug interactions for Trimetazidine Hcl 120mg Capsule:

• Concomitant use with beta-blockers may cause excessive bradycardia and atrioventricular block.
• The effect of anti-arrhythmic drugs may be reduced due to its negative inotropic effect.
• It can enhance the negative inotropic effect of diltiazem and verapamil.
• Avoid the use of trimetazidine with Class 1 antiarrhythmic drugs like quinidine.
• Trimetazidine may reduce the anti-anginal efficacy of organic nitrates.
• It can decrease the anticoagulant effect of warfarin and increase the risk of bleeding with clopidogrel.
• Trimetazidine may increase the concentration of digoxin, requiring close monitoring.

Following are the food interactions for Trimetazidine Hcl 120mg Capsule:

• Avoid consuming large amounts of grapefruit or grapefruit juice as it may affect the metabolism of the drug, leading to increased levels in the body.
• Alcohol consumption should be limited as it may cause additional dizziness and increase the risk of side effects.
• Caffeine intake should be monitored as it can enhance the drug's effect on the heart and blood vessels.
• Avoid high-fat meals as they can delay the absorption of Trimetazidine, potentially affecting its effectiveness.
• Do not consume energy drinks or excessive amounts of sugar, as Trimetazidine may affect blood sugar levels.
• Certain dairy products with high-fat content might interfere with the absorption of the medication.
• Avoid natural licorice as it may interact with Trimetazidine, affecting blood pressure regulation.
• Always follow the dietary advice provided by your healthcare professional while taking this medication.

Trimetazidine Hcl 120mg Capsules should be stored in a secure and dry location, preferably in a medicine cabinet or designated storage area, ensuring they are out of the reach of children and pets. Maintain a consistent room temperature, avoiding exposure to direct sunlight, excessive heat, or moisture, as these conditions can degrade the medication's quality. Always keep the capsules in their original packaging, tightly sealed, to prevent contamination and maintain their integrity. Regularly check the expiration date on the package, and do not use or store the medication beyond this date. When disposing of unused or expired capsules, do not flush them down the toilet or dispose of them in household trash. Instead, follow local guidelines or consult a pharmacist for safe disposal methods to minimize environmental impact. Responsible storage and disposal practices are crucial to ensure the effectiveness of the medication and protect the well-being of your household.

Following are the quick tips for Trimetazidine Hcl 120mg Capsule:

• Take the capsule as directed by your doctor, usually once or twice daily.
• Swallow the capsule whole with a full glass of water, preferably during or after meals.
• Do not crush, chew, or break the capsule, as it may affect its effectiveness.
• Maintain a consistent dosing schedule to ensure the best treatment outcome.
• Inform your doctor if you have any heart or kidney-related medical conditions.
• Store the capsules in a cool, dry place, away from direct sunlight and moisture.
• Regularly monitor your health and report any unusual symptoms to your healthcare provider.