TRIVASTAL RET TAB

Piribedil's primary mechanism of action is as a dopamine agonist, which means it stimulates dopamine receptors in the brain. It has a high affinity for D2 and D3 dopamine receptors, mimicking the effects of dopamine, a neurotransmitter involved in various physiological processes, including movement, cognition, and mood regulation. By activating these receptors, Piribedil increases dopamine activity in the brain, which is particularly beneficial in conditions where dopamine deficiency is present. This can lead to improved motor function in patients with Parkinson's disease, as it helps reduce the motor symptoms associated with the disease. Additionally, Piribedil's action on dopamine receptors may contribute to its potential cognitive-enhancing and mood-elevating effects, making it a versatile medication for managing various neurological disorders.

Dopamine agonist.

Tablet

The following are the uses of Piribedil Tablet:

• Used for treating Parkinson's disease and its symptoms, improving muscle control and reducing stiffness.
• Used for managing restless legs syndrome, providing relief from uncomfortable leg sensations.
• Used for enhancing blood flow to the brain, potentially improving cognitive function and memory.
• Used for treating depression associated with Parkinson's disease, helping to improve mood and emotional well-being.
• Used for managing dizziness and balance issues related to circulation problems.
• Used for supporting overall brain health and cognitive function in elderly patients.
• Used for reducing the side effects of certain antipsychotic medications, particularly those affecting movement.

In the case of an overdose of Piribedil Tablets, individuals may experience a range of symptoms. These can include severe nausea, vomiting, dizziness, and a significant drop in blood pressure. In severe cases, patients might also develop hallucinations, confusion, and even lose consciousness. It is imperative to seek medical assistance promptly if an overdose is suspected, as healthcare professionals can provide the necessary treatment and support to manage these symptoms effectively.

In the case of a missed dose of Piribedil Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for advice, as they may recommend adjusting your dosage or provide specific instructions for catching up on missed doses. It is generally best to maintain a consistent medication routine, but don't worry if you occasionally miss a dose.

To take Piribedil Tablet, swallow the tablet whole with a full glass of water, preferably with or after a meal, following the dosage instructions provided by your doctor, typically starting with a low dose and gradually increasing as directed.

Following are the conditions when Piribedil Tablet should not be used:

• Contraindicated in individuals with known hypersensitivity or allergy to Piribedil or any of its excipients.
• Should not be used in patients with severe kidney or liver impairment.
• Not recommended for individuals with severe cardiovascular diseases or unstable hypertension.
• Contraindicated during pregnancy and breastfeeding.
• Should not be used in children and adolescents under 18 years of age.
• Patients with a history of gastrointestinal bleeding or peptic ulcer should avoid this medication.
• Not suitable for individuals with severe lung diseases or respiratory disorders.

The side effects of Piribedil Tablet may include:

• Nausea and vomiting
• Dizziness and lightheadedness
• Fatigue and drowsiness
• Dry mouth
• Constipation or diarrhea
• Skin rashes and itching
• Involuntary movements (dyskinesia)
• Leg swelling (peripheral edema)

Following are the precautions and warnings for Piribedil Tablet:

• Not recommended for individuals with a known hypersensitivity or allergy to Piribedil or any of its excipients.
• Patients with a history of kidney or liver disease should use with caution and under medical supervision, as dosage adjustments may be necessary.
• This medication may cause drowsiness or dizziness, so patients should avoid driving, operating heavy machinery, or engaging in activities requiring mental alertness until they know how the medication affects them.
• Alcohol consumption should be avoided as it may enhance the sedative effects of Piribedil.
• Piribedil may cause orthostatic hypotension; patients should be cautious when standing up from a sitting or lying position to prevent falls.
• Not recommended for use in children, as safety and efficacy have not been established in this age group.
• Women who are pregnant, planning to become pregnant, or breastfeeding should consult their doctor before taking Piribedil, as the risks and benefits should be carefully evaluated.

Following are the drug interactions for Piribedil Tablet:

• Piribedil may interact with other dopamine agonists or antagonists, such as Levodopa, leading to an exaggerated response or reduced effectiveness.
• It can enhance the sedative effects of CNS depressants like benzodiazepines and opioids, requiring close monitoring.
• Antipsychotic medications may counteract the effects of Piribedil, and their concurrent use should be carefully evaluated.
• Caution is advised when combining Piribedil with antihypertensive drugs, as it may lower blood pressure, requiring dose adjustments.
• The effectiveness of Piribedil may be reduced by drugs that induce certain liver enzymes, potentially requiring increased Piribedil doses.
• Piribedil may interact with anti-nausea medications, affecting their efficacy and requiring dosage adjustments.
• Close monitoring is necessary when using Piribedil with other medications that prolong QT intervals, due to potential cardiac risks.

Following are the food interactions for Piribedil Tablet:

• Grapefruit consumption should be avoided as it can lead to increased levels of Piribedil in the blood, potentially causing adverse effects.
• Alcohol should be consumed with caution as it may increase the sedative effects of Piribedil, resulting in enhanced drowsiness and dizziness.
• Caffeine intake should be monitored as it might counteract the therapeutic effects of Piribedil, affecting its efficacy in treating Parkinson's disease.
• Fava beans and aged cheeses are rich in tyramine, and their consumption should be limited as they can potentially interact with Piribedil, leading to increased blood pressure.
• Foods high in vitamin C, like citrus fruits and broccoli, may affect the absorption of Piribedil, and it's advisable to maintain a consistent intake of these foods during treatment.
• Avoid high-fat meals as they can potentially delay the absorption of Piribedil, impacting the medication's onset of action.
• Dairy products may interfere with Piribedil absorption; consider separating the medication and dairy intake by a few hours.
• Maintain a balanced diet to ensure the medication's effectiveness, as Piribedil may interact with certain nutrients, affecting overall treatment outcomes.

Piribedil tablets should be stored in a cool, dry place, preferably at room temperature between 68°F and 77°F (20°C and 25°C). Keep the tablets in their original container, tightly sealed, to protect them from moisture and light. Avoid storing them in the bathroom or kitchen, as these areas may have high humidity and temperature fluctuations. Always check the expiration date before using the medication, and discard any expired or unused tablets according to local regulations and guidelines. Do not flush the tablets down the toilet or throw them into the trash; instead, utilize medicine take-back programs or consult your pharmacist for safe disposal options. Keep the medication safely locked away from children and pets to prevent accidental consumption.

Following are the quick tips for Piribedil Tablet:

• Take the tablet as directed by your doctor, typically 1 to 3 times daily.
• Swallow the tablet whole with a full glass of water, preferably during or after meals.
• Maintain a consistent daily routine for taking the medication.
• If you miss a dose, skip it and continue with the next scheduled dose; do not double the dose.
• Do not stop taking the medication without consulting your doctor, even if you feel better.
• Inform your doctor about all other medications you are taking to prevent potential interactions.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.