Truca -150 (150mg) 100 Tablets

Fluconazole 150mg tablets primarily work by inhibiting the enzyme lanosterol 14-alpha-demethylase, which is crucial for the synthesis of ergosterol, a major component of fungal cell membranes. By blocking this enzyme, fluconazole disrupts the integrity of fungal cell membranes, leading to the leakage of intracellular components and ultimately causing fungal cell death. This selective action against fungal cells is due to the fact that ergosterol is specific to fungi, while mammalian cells contain cholesterol, which is not affected by fluconazole. This mechanism of action allows fluconazole to effectively target and eliminate a wide range of fungal pathogens while minimizing toxicity to human cells.

Fluconazol 150mg

Antifungal

Tablet

The following are the uses of Fluconazol 150mg Tablet:

• Used for treating vaginal yeast infections, providing quick relief and preventing recurrence.
• Used for managing fungal infections in various body parts, including the mouth, throat, and esophagus.
• Effective for treating fungal infections in patients with compromised immune systems, such as those with HIV or undergoing cancer treatment.
• Used as a preventive measure for individuals at high risk of developing systemic fungal infections.
• Provides relief from fungal skin infections, including athlete's foot, ringworm, and jock itch.
• Used in the treatment of severe fungal infections that may have spread throughout the body.
• Helps combat fungal infections in patients with low white blood cell counts due to chemotherapy or radiation therapy.

In the case of an overdose of Fluconazol 150mg Tablets, individuals may experience symptoms such as hallucinations, abnormal behavior, and gastrointestinal issues like nausea, vomiting, and diarrhea. The severity of these symptoms can vary depending on the amount ingested. It is important to seek medical advice promptly if an overdose is suspected, as healthcare professionals can provide appropriate guidance and treatment options to manage the situation effectively.

In the case of a missed dose of Fluconazol 150mg Tablet, it is generally recommended to take the missed dose as soon as you remember, provided there is a sufficient gap before the next scheduled dose. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one, as this may increase the risk of side effects. Consult your healthcare provider if you frequently miss doses or are unsure about how to manage missed doses.

To take Fluconazol 150mg Tablet, swallow the tablet whole with a full glass of water, preferably at the same time each day, as directed by your healthcare professional, without crushing or chewing it.

Following are the conditions when Fluconazole 150mg Tablet should not be taken:

• Avoid if you have a known allergy to Fluconazole or other azole antifungal medications.
• Do not take if you are pregnant or planning to become pregnant, as it may cause harm to the developing fetus.
• Contraindicated in patients with liver disease or impaired liver function.
• Should not be used if you have a history of QT prolongation or heart rhythm disorders.
• Avoid using if you have a rare hereditary problem of galactose intolerance, severe lactase deficiency, or glucose-galactose malabsorption.
• Do not take if you are currently taking certain medications that may interact with Fluconazole, such as cisapride, pimozide, quinidine, or ergot medicines.
• Not suitable for individuals with a history of hypersensitivity reactions to similar antifungal drugs.

The side effects of Fluconazole 150mg Tablet may include:

• Nausea and vomiting
• Diarrhea
• Abdominal pain
• Headache
• Dizziness
• Skin rash or itching
• Increased liver enzymes (detected in blood tests)
• Fatigue

Following are the precautions and warnings for Fluconazol 150mg Tablet:

• Not recommended for individuals with known hypersensitivity or allergy to Fluconazole or other azole antifungal medications.
• Patients with liver or kidney impairment should be monitored closely, as dosage adjustments may be necessary.
• May cause liver damage, so it is crucial to monitor liver function, especially during prolonged treatment.
• Can increase the concentration of certain drugs metabolized by the liver, potentially leading to increased side effects.
• Not recommended for pregnant women unless the potential benefits outweigh the risks.
• Should be used with caution in breastfeeding women as Fluconazole can pass into breast milk.
• Elderly patients may be more susceptible to side effects, particularly those related to the central nervous system and liver.
• Patients with rare hereditary problems of galactose intolerance, severe lactase deficiency, or glucose-galactose malabsorption should not take this medication.

Following are the drug interactions for Fluconazole 150mg Tablet:

• Fluconazole inhibits CYP3A4, leading to increased levels of drugs metabolized by this enzyme, such as cisapride, midazolam, and phenytoin.
• Fluconazole may enhance the anticoagulant effect of warfarin, requiring close monitoring of INR.
• Rifampin can reduce the effectiveness of fluconazole by inducing its metabolism.
• Fluconazole can increase phenytoin levels, potentially requiring phenytoin dose adjustment.
• Fluconazole can elevate cyclosporine levels, necessitating cyclosporine dose reduction.
• Similar to cyclosporine, fluconazole can increase tacrolimus levels, requiring dose adjustment.
• Fluconazole may cause hypoglycemia when used with sulfonylureas by inhibiting their metabolism.

Following are the food interactions for Fluconazol 150mg Tablet:

• Avoid consuming grapefruit and grapefruit juice, as they can increase the concentration of Fluconazole in the blood, potentially leading to increased side effects.
• Alcohol consumption should be limited or avoided as it may cause liver-related issues and increase the risk of side effects.
• Avoid high-fat meals as they can decrease the absorption of Fluconazole, reducing its effectiveness.
• Dairy products like milk, cheese, and yogurt can decrease the absorption of Fluconazole, so it's best to separate them by a few hours.
• Caffeinated beverages like coffee and tea may increase the metabolism of Fluconazole, affecting its effectiveness.
• Avoid consuming excessive amounts of sugar, especially in patients with diabetes, as Fluconazole can cause hyperglycemia.
• Certain acidic foods like citrus fruits and juices may interfere with the absorption of Fluconazole.
• Always consult your healthcare provider for specific dietary recommendations while taking this medication.

Fluconazol 150mg Tablets should be stored in a cool, dry area, ideally at room temperature, away from direct sunlight and moisture. The original packaging should be tightly sealed to maintain its integrity and prevent contamination. It is crucial not to expose the tablets to excessive heat or cold, so avoid storing them near ovens, radiators, or in the refrigerator. Always check the expiration date, and dispose of any unused tablets properly, never flushing them down the toilet or sink. Consult your pharmacist for safe disposal practices to protect the environment. Keep this medication securely stored away from children to prevent accidental consumption.

Following are the quick tips for Fluconazol 150mg Tablet:

• Take the tablet as directed by your doctor, typically as a single dose or as prescribed.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• It can be taken with or without food, but taking it with food may reduce the risk of stomach upset.
• If you experience mild diarrhea, continue treatment and drink plenty of fluids.
• Contact your doctor if you develop a rash or persistent diarrhea during or after treatment.
• Avoid alcohol consumption while taking this medication as it may increase side effects.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.