TRUFLEX TAB

TRUFLEX TAB

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  • Manufacturer BIO PHARMACEUTICALS (PVT.) LTD.
  • Generic Name

    Diclofenac 50mg, Metaxalone 400mg

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Description

    Diclofenac, a component of the Diclofenac 50mg, Metaxalone 400mg Tablet, is a non-steroidal anti-inflammatory drug (NSAID) that primarily works by inhibiting the production of prostaglandins. It achieves this by blocking cyclooxygenase (COX) enzymes, particularly COX-2, which is responsible for the synthesis of prostaglandins involved in pain and inflammation. By reducing prostaglandin levels, diclofenac helps alleviate pain, decrease inflammation, and lower fever. On the other hand, metaxalone, the other component of the tablet, is a muscle relaxant that acts centrally on the spinal cord and brainstem to reduce muscle spasticity. It does not directly affect the neuro-muscular junction or skeletal muscle fibers. The exact mechanism of action of metaxalone is not fully understood, but it is believed to work by inhibiting the release of excitatory neurotransmitters, leading to a reduction in muscle spasms and associated pain.

  • Ingredients

    Diclofenac 50mg, Metaxalone 400mg

  • Drug Class

    NSAID, Muscle Relaxant.

  • Dosage Form

    Tablet

  • Uses

    The following are the uses of Diclofenac 50mg, Metaxalone 400mg Tablet:

    • Used for relieving pain and inflammation associated with various conditions such as arthritis, sprains, and acute injuries.
    • Used for reducing muscle spasms and associated pain, particularly in the back and neck region.
    • Used for managing post-operative pain and inflammation following surgical procedures.
    • Used for treating headaches and migraines by reducing pain and associated inflammation.
    • Used for providing relief from menstrual cramps and associated discomfort.
    • Used for easing toothaches and pain caused by dental procedures.
    • Used for alleviating symptoms of fever and discomfort in conditions like flu and common cold.
  • In case of Overdose

    In the case of an overdose of Diclofenac 50mg or Metaxalone 400mg Tablets, it is important to act promptly. Symptoms may include nausea, vomiting, stomach pain, and in severe cases, seizures or loss of consciousness. If you suspect an overdose, contact a healthcare professional or a poison control center immediately. They will provide guidance on the necessary steps, which may include medical observation, supportive care, and treatment to manage symptoms and prevent potential complications.

  • Missed Dose

    In the case of a missed dose of Diclofenac 50mg, take the missed dose as soon as you remember, but if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the dose to make up for the missed one. For Metaxalone 400mg Tablet, if you miss a dose, take it as soon as you remember, however, if it is closer to the time of your next dose, skip the missed dose and continue with your regular dosing schedule. It is important not to take extra medication to compensate for a missed dose.

  • How To Use

    To take Diclofenac 50mg and Metaxalone 400mg tablets, swallow the tablets whole with a full glass of water, preferably with or after a meal, following the dosage instructions provided by your healthcare professional.

  • When Not to Use

    Following are the conditions/situations when Diclofenac 50mg and Metaxalone 400mg Tablet should not be used:

    • Should not be taken by individuals who have a known allergy or hypersensitivity to Diclofenac, Metaxalone, or any other NSAIDs (Non-Steroidal Anti-Inflammatory Drugs).
    • Contraindicated in patients with active or recent gastrointestinal bleeding or perforation.
    • Not suitable for individuals with severe heart failure or cardiovascular disease.
    • Should be avoided in patients with a history of stomach ulcers or gastrointestinal disorders.
    • Not recommended for individuals with impaired kidney or liver function.
    • Contraindicated during the last trimester of pregnancy and in breastfeeding mothers.
    • Should not be used in patients with known bleeding disorders or those taking anticoagulant medications.
    • Avoid in patients with a history of asthma or allergic reactions triggered by aspirin or other NSAIDs.
  • Side Effects

    The side effects of Diclofenac 50mg, Metaxalone 400mg Tablet may include:

    • Stomach pain or discomfort
    • Nausea and vomiting
    • Diarrhea
    • Dizziness or vertigo
    • Headache
    • Skin rash or itching
    • Increased liver enzymes
    • Drowsiness or fatigue
  • Precautions & Warnings

    Following are the precautions and warnings for Diclofenac 50mg, Metaxalone 400mg Tablet:

    • Individuals with a known allergy to Diclofenac, Metaxalone, or any other NSAIDs should not take this medication.
    • Patients with a history of gastrointestinal bleeding, stomach ulcers, or kidney problems should exercise caution and consult a doctor before use, as it may worsen these conditions.
    • This medication may increase the risk of cardiovascular events like heart attack or stroke, especially with prolonged use. Patients with cardiovascular disease should use it with caution.
    • Not recommended for use in pregnant or breastfeeding women unless absolutely necessary and under medical supervision.
    • Elderly patients may be more susceptible to side effects, particularly gastrointestinal bleeding and kidney problems.
    • Avoid alcohol consumption while taking this medication, as it may increase the risk of gastrointestinal bleeding and liver toxicity.
    • Consult a doctor if you have a history of liver disease, as this medication can affect liver function.
  • Drug Interactions

    Following are the drug interactions for Diclofenac 50mg, Metaxalone 400mg Tablet:

    • May increase risk of bleeding when taken with anticoagulants like warfarin, clopidogrel, or antiplatelet medications.
    • Can reduce the efficacy of diuretics and antihypertensive drugs, requiring careful monitoring of blood pressure.
    • Use with other NSAIDs or corticosteroids may increase the risk of gastrointestinal bleeding and kidney problems.
    • Potential interaction with lithium, increasing lithium levels and the risk of lithium toxicity.
    • Caution with ACE inhibitors or ARBs, as Diclofenac may decrease their effectiveness in treating heart conditions.
    • Metaxalone can enhance the effects of CNS depressants like benzodiazepines and opioids, leading to increased sedation.
    • May affect the metabolism of certain medications, including warfarin, increasing the risk of bleeding.
  • Food Interactions

    Following are the food interactions for Diclofenac 50mg and Metaxalone 400mg Tablet:

    • Alcohol consumption should be avoided or limited while taking Diclofenac as it may increase the risk of stomach bleeding and liver-related side effects.
    • Diclofenac may decrease the blood flow to the stomach, making it more sensitive, so it's best to avoid spicy or irritating foods.
    • Grapefruit juice should be avoided as it can affect the breakdown of Diclofenac, potentially increasing its levels in the body.
    • Metaxalone may cause stomach upset, so it's advisable to take it with food or milk to minimize this effect.
    • Avoid consuming large amounts of caffeine-containing beverages (coffee, tea, colas) as they may reduce the absorption of Metaxalone.
    • Consuming a high-fat meal before taking Metaxalone may increase its absorption and potentially enhance its effects.
    • It is generally safe to eat a balanced diet while taking these medications, but always follow your doctor's advice on dietary restrictions.
    • Consult your healthcare provider for personalized advice regarding food interactions with these medications.
  • Storage/Disposal

    Diclofenac 50mg and Metaxalone 400mg tablets should be stored in a cool, dry place, preferably at room temperature, away from sunlight and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to external elements. Ensure you store the medication away from heat sources like ovens or heaters, as temperature fluctuations can impact its effectiveness. Regularly check the expiration date, and properly dispose of any unused or expired tablets. It is crucial to avoid flushing the medication down the toilet or sink; instead, seek guidance from a pharmacist or healthcare professional for safe disposal methods. Keep the medication securely stored, out of the reach of children, to prevent accidental consumption.

  • Quick Tips, if any

    Following are the quick tips for Diclofenac 50mg and Metaxalone 400mg Tablet:

    • Consult a doctor before use if you have a history of gastrointestinal problems, heart disease, or high blood pressure.
    • Take the tablet with food to minimize stomach irritation.
    • Do not crush or chew the tablet; swallow it whole with a full glass of water.
    • Avoid alcohol consumption while using these medications.
    • Inform your doctor about all the medications you are taking to prevent potential drug interactions.
    • If you experience dizziness, avoid driving or operating heavy machinery.
    • Store the tablets at room temperature, away from moisture and direct sunlight.
    • Discontinue use and seek medical attention if you develop severe skin reactions or persistent stomach pain.

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