Trufol-OD (600mcg) 30 Tablets

Quatrefolic 600mcg Tablet contains the active ingredient 5-methyltetrahydrofolate, which is a biologically active form of folate. Its mechanism of action revolves around its role as a methyl donor in various biochemical reactions. The tablet bypasses the need for enzymatic conversion, which is required for other forms of folate, and directly provides the body with the active 5-methyltetrahydrofolate. This is particularly important for individuals with genetic variations in the MTHFR (methylenetetrahydrofolate reductase) enzyme, who may have difficulty converting folic acid to its active form. By supplying the body with this essential nutrient, Quatrefolic supports critical processes such as DNA synthesis, amino acid metabolism, and the production of neurotransmitters, all of which are vital for cellular function, tissue growth, and overall health.

Folic acid derivative.

Tablet

The following are the uses of Quatrefolic 600mcg Tablet:

• Used for reducing the risk of neural tube defects in pregnancy.
• Used to support brain and spinal cord development in early pregnancy.
• Used for treating folate deficiency, aiding in DNA synthesis.
• Used to manage homocysteine levels, reducing heart disease risk.
• Used for enhancing red blood cell production and preventing anemia.
• Used in combination with other vitamins for overall prenatal health.
• Used to improve egg quality and support fertility treatments.
• Used during breastfeeding to maintain maternal folate levels.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Psychiatric Disorders • 7 to 15 mg per day for reducing depression and anxiety symptoms; 15 to 50 mg per day for treating severe psychiatric disorders like schizophrenia
• Anemia • 1 to 5 mg a day to improve symptoms associated with anemia like fatigue and weakness
• Neural Tube Defects • 200 to 800 µg per day to reduce the risk of neural tube defects in pregnant women
• Hepatitis C • 500 to 3,000 mg per day to reduce complications associated with liver damage and to improve treatment response
• Depression • between 1 to 15 mg daily to improve the effectiveness of antidepressant therapies

In the case of an overdose of Quatrefolic 600mcg Tablets, individuals may experience symptoms such as gastrointestinal disturbances, including nausea, vomiting, and diarrhea. Other potential effects could include fatigue, dizziness, and skin rashes. It is crucial to promptly contact a healthcare professional or a poison control center for guidance and support. They will provide specific instructions and recommend appropriate medical interventions to manage the overdose and ensure the individual's well-being.

In the case of a missed dose of Quatrefolic 600mcg Tablet, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose to maintain a consistent dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication regimen. It is important to follow the prescribed dosage instructions to ensure the medication's effectiveness.

To take Quatrefolic 600mcg Tablet, place the tablet under your tongue and allow it to dissolve completely, preferably first thing in the morning on an empty stomach, following the dosage instructions provided by your healthcare professional.

Following are the conditions when Quatrefolic 600mcg Tablet should not be used:

• Should not be taken by individuals who are allergic to 5-methyltetrahydrofolate, folic acid, or any of the tablet's inactive ingredients.
• Contraindicated in patients with untreated or undiagnosed anemia.
• Not recommended for individuals with a history of allergic reactions to folic acid or similar medications.
• Avoid use if you have a known hypersensitivity to any form of folate or have a history of seizures.

The side effects of Quatrefolic 600mcg Tablet may include:

• Gastrointestinal issues such as nausea, vomiting, or diarrhea.
• Allergic reactions, including skin rashes, itching, or hives.
• Headaches and dizziness.
• Fatigue and weakness.
• Sleep disturbances, including insomnia.
• Mood changes, such as irritability or anxiety.
• Increased heart rate or palpitations.
• Mild digestive discomfort.

Following are the precautions and warnings for Quatrefolic 600mcg Tablet:

• Not recommended for individuals with a known hypersensitivity or allergy to any of its active or inactive ingredients.
• Patients with a history of gastrointestinal disorders should use with caution, as it may cause mild gastrointestinal side effects.
• Those with a history of liver or kidney disease should consult their healthcare provider before use, as the dosage may need adjustment.
• Patients on medications such as methotrexate, sulfonamides, or phenytoin should inform their doctor, as Quatrefolic may interact with these drugs.
• This supplement should not be used as a substitute for a balanced diet; it is not a replacement for food-based folate.
• Pregnant and breastfeeding women should consult their doctor before taking this supplement, as folic acid requirements may vary during these periods.
• Keep out of reach of children. Store in a cool, dry place, away from direct sunlight.

Following are the drug interactions for Quatrefolic 600mcg Tablet:

• Prolonged use of Quatrefolic with methotrexate may lead to increased methotrexate toxicity, hence close monitoring is required.
• It can interact with antiepileptic drugs like phenytoin, carbamazepine, and phenobarbital, potentially reducing their effectiveness.
• Concomitant use with sulfonamides may reduce the absorption of folic acid.
• Antagonism with pyrimethamine and trimethoprim has been observed, leading to reduced efficacy of these drugs.
• May decrease the therapeutic efficacy of methotrexate, hence close monitoring is required.
• The effectiveness of pyrimethamine and trimethoprim may be reduced when taken with Quatrefolic.
• Use with caution alongside antiepileptic medications, as it may decrease seizure control.

Following are the food interactions for Quatrefolic 600mcg Tablet:

• Alcohol, Avoid excessive alcohol consumption while taking this medication as it may interfere with the absorption of the active ingredient, L-Methylfolate.
• Folate-rich foods, Consuming foods high in natural folates, like leafy green vegetables, citrus fruits, and beans, alongside Quatrefolic, can enhance its effectiveness, ensuring optimal folate levels.
• Antacid medications, Taking antacids close to Quatrefolic may reduce its absorption. Consider spacing doses of antacids and Quatrefolic by a few hours.
• Vitamin C-rich foods, Vitamin C can enhance the absorption of folate. Include citrus fruits, bell peppers, and broccoli in your diet for better absorption.
• Processed foods, Limit processed foods as they often contain folic acid, which may compete with L-Methylfolate for absorption, potentially reducing the medication's effectiveness.
• Caffeine, Limit caffeine intake as it may interfere with the body's ability to absorb and utilize folate.
• High-fiber foods, Consuming high-fiber foods like whole grains, legumes, and certain vegetables can slow the absorption of Quatrefolic. Consider spacing the medication and these foods by a few hours.
• Dairy products, Calcium in dairy products can potentially interact with Quatrefolic, affecting its absorption. Consider separating calcium-rich foods and the medication by a few hours.

Quatrefolic 600mcg Tablets should be stored in a secure and dry location, preferably at room temperature, ensuring protection from direct sunlight and moisture. The original packaging should be tightly sealed to maintain the integrity of the tablets and prevent exposure to contaminants. It is crucial not to store the medication in bathrooms or near heat sources, as temperature fluctuations can impact its effectiveness. Remember to regularly check the expiration date, and when disposing of unused or expired tablets, avoid flushing or pouring them down the drain. Instead, consult a pharmacist or healthcare professional for safe disposal practices, and always keep medicines out of children's reach to prevent accidental consumption.

Following are the quick tips for Quatrefolic 600mcg Tablet:

• Always consult your doctor before starting this medication to ensure it's suitable for you.
• Take the tablet as directed by your healthcare provider, typically once daily.
• Swallow the tablet whole with a glass of water; do not crush or chew it.
• Maintain a consistent daily routine for taking the medication for best results.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.
• Inform your doctor about all the medications you are taking to avoid potential interactions.
• Contact your healthcare provider if you experience any unusual symptoms or side effects.

L-Methylfolate is a prescription supplement used for dietary deficiencies and medical conditions. Lab tests are needed to monitor specific health parameters while taking L-Methylfolate, depending on the individual's age, medical history, and potential drug interactions. Physician supervision is essential when taking L-Methylfolate, and frequent lab testing may be required to prevent undesirable effects. Blood tests, genetic testing, and kidney function tests are the three main lab tests that may be required. Blood tests ensure no fluctuations in essential nutrient or electrolyte levels, genetic testing can tailor L-Methylfolate dosage and monitoring, and kidney function tests can monitor preexisting conditions or electrolyte imbalances. Physician guidance is necessary for any medical condition, drug interactions, or dosage adjustments.